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Gene: TTTY14 |
Gene summary for TTTY14 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TTTY14 | Gene ID | 83869 |
| Gene name | testis-specific transcript, Y-linked 14 | |
| Gene Alias | CYorf14 | |
| Cytomap | Yq11.222 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 83869 | TTTY14 | A002-C-021 | Human | Colorectum | FAP | 1.97e-25 | -7.76e-01 | 0.1171 |
| 83869 | TTTY14 | A002-C-205 | Human | Colorectum | FAP | 2.18e-30 | -8.24e-01 | -0.1236 |
| 83869 | TTTY14 | A014-C-108 | Human | Colorectum | FAP | 2.01e-19 | -8.23e-01 | -0.124 |
| 83869 | TTTY14 | A001-C-104 | Human | Colorectum | FAP | 1.91e-02 | -3.86e-01 | 0.0184 |
| 83869 | TTTY14 | A015-C-005 | Human | Colorectum | FAP | 3.96e-21 | -7.98e-01 | -0.0336 |
| 83869 | TTTY14 | A015-C-006 | Human | Colorectum | FAP | 8.05e-21 | -8.24e-01 | -0.0994 |
| 83869 | TTTY14 | A015-C-106 | Human | Colorectum | FAP | 9.61e-34 | -8.24e-01 | -0.0511 |
| 83869 | TTTY14 | A002-C-114 | Human | Colorectum | FAP | 1.33e-21 | -7.39e-01 | -0.1561 |
| 83869 | TTTY14 | A015-C-104 | Human | Colorectum | FAP | 7.31e-40 | -8.03e-01 | -0.1899 |
| 83869 | TTTY14 | A015-C-202 | Human | Colorectum | FAP | 5.07e-27 | -8.33e-01 | -0.0849 |
| 83869 | TTTY14 | A001-C-014 | Human | Colorectum | FAP | 5.81e-22 | -6.52e-01 | 0.0135 |
| 83869 | TTTY14 | A002-C-016 | Human | Colorectum | FAP | 4.96e-25 | -7.35e-01 | 0.0521 |
| 83869 | TTTY14 | A015-C-002 | Human | Colorectum | FAP | 6.68e-18 | -8.30e-01 | -0.0763 |
| 83869 | TTTY14 | A001-C-203 | Human | Colorectum | FAP | 4.78e-06 | -3.83e-01 | -0.0481 |
| 83869 | TTTY14 | A002-C-116 | Human | Colorectum | FAP | 6.42e-22 | -3.86e-01 | -0.0452 |
| 83869 | TTTY14 | A008-E-015 | Human | Colorectum | FAP | 2.23e-30 | -8.07e-01 | 0.0177 |
| 83869 | TTTY14 | A014-C-008 | Human | Colorectum | FAP | 1.82e-21 | -8.64e-01 | -0.191 |
| 83869 | TTTY14 | A018-E-020 | Human | Colorectum | FAP | 5.82e-12 | -4.40e-01 | -0.2034 |
| 83869 | TTTY14 | F034 | Human | Colorectum | FAP | 2.77e-30 | -7.71e-01 | -0.0665 |
| 83869 | TTTY14 | F072B | Human | Colorectum | FAP | 1.71e-34 | -8.31e-01 | 0.257 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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