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Gene: TTC38 |
Gene summary for TTC38 |
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Gene information | Species | Human | Gene symbol | TTC38 | Gene ID | 55020 |
Gene name | tetratricopeptide repeat domain 38 | |
Gene Alias | LL22NC03-5H6.5 | |
Cytomap | 22q13.31 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q5R3I4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55020 | TTC38 | F034 | Human | Colorectum | FAP | 1.23e-03 | -1.59e-01 | -0.0665 |
55020 | TTC38 | F072B | Human | Colorectum | FAP | 5.94e-03 | -2.26e-01 | 0.257 |
55020 | TTC38 | CRC-3-11773 | Human | Colorectum | CRC | 3.11e-02 | -1.47e-01 | 0.2564 |
55020 | TTC38 | NAFLD1 | Human | Liver | NAFLD | 5.99e-11 | 1.01e+00 | -0.04 |
55020 | TTC38 | S43 | Human | Liver | Cirrhotic | 7.11e-09 | -3.88e-02 | -0.0187 |
55020 | TTC38 | HCC1_Meng | Human | Liver | HCC | 1.05e-59 | -1.72e-02 | 0.0246 |
55020 | TTC38 | HCC2_Meng | Human | Liver | HCC | 1.48e-19 | -4.96e-02 | 0.0107 |
55020 | TTC38 | HCC1 | Human | Liver | HCC | 3.53e-03 | 3.37e+00 | 0.5336 |
55020 | TTC38 | HCC2 | Human | Liver | HCC | 1.66e-05 | 2.70e+00 | 0.5341 |
55020 | TTC38 | S014 | Human | Liver | HCC | 1.63e-13 | 7.99e-01 | 0.2254 |
55020 | TTC38 | S015 | Human | Liver | HCC | 1.57e-17 | 1.07e+00 | 0.2375 |
55020 | TTC38 | S016 | Human | Liver | HCC | 5.81e-15 | 6.99e-01 | 0.2243 |
55020 | TTC38 | S027 | Human | Liver | HCC | 1.33e-03 | 7.92e-01 | 0.2446 |
55020 | TTC38 | S028 | Human | Liver | HCC | 3.04e-15 | 9.37e-01 | 0.2503 |
55020 | TTC38 | S029 | Human | Liver | HCC | 2.20e-16 | 9.92e-01 | 0.2581 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTC38 | SNV | Missense_Mutation | novel | c.946G>A | p.Val316Ile | p.V316I | Q5R3I4 | protein_coding | tolerated(0.19) | benign(0.007) | TCGA-A7-A4SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
TTC38 | SNV | Missense_Mutation | c.448G>T | p.Asp150Tyr | p.D150Y | Q5R3I4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TTC38 | SNV | Missense_Mutation | rs766399816 | c.632N>T | p.Pro211Leu | p.P211L | Q5R3I4 | protein_coding | deleterious(0.04) | possibly_damaging(0.768) | TCGA-E9-A2JS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamide | PD |
TTC38 | SNV | Missense_Mutation | c.1249N>A | p.Val417Ile | p.V417I | Q5R3I4 | protein_coding | tolerated(0.28) | benign(0.037) | TCGA-EW-A1J6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD | |
TTC38 | SNV | Missense_Mutation | novel | c.1254N>G | p.Phe418Leu | p.F418L | Q5R3I4 | protein_coding | deleterious(0.01) | possibly_damaging(0.904) | TCGA-MY-A913-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TTC38 | SNV | Missense_Mutation | c.1000N>A | p.Ala334Thr | p.A334T | Q5R3I4 | protein_coding | tolerated(0.05) | benign(0.296) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TTC38 | SNV | Missense_Mutation | rs753722029 | c.589N>A | p.Asp197Asn | p.D197N | Q5R3I4 | protein_coding | deleterious(0.01) | benign(0.345) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
TTC38 | SNV | Missense_Mutation | c.500G>A | p.Arg167Gln | p.R167Q | Q5R3I4 | protein_coding | deleterious(0.01) | possibly_damaging(0.619) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TTC38 | SNV | Missense_Mutation | c.500N>A | p.Arg167Gln | p.R167Q | Q5R3I4 | protein_coding | deleterious(0.01) | possibly_damaging(0.619) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TTC38 | SNV | Missense_Mutation | rs372817703 | c.1180G>A | p.Val394Ile | p.V394I | Q5R3I4 | protein_coding | deleterious(0.04) | benign(0.299) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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