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Gene: TTC32 |
Gene summary for TTC32 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TTC32 | Gene ID | 130502 |
| Gene name | tetratricopeptide repeat domain 32 | |
| Gene Alias | TTC32 | |
| Cytomap | 2p24.1 | |
| Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q5I0X7 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 130502 | TTC32 | P21T-E | Human | Esophagus | ESCC | 2.93e-17 | 2.68e-01 | 0.1617 |
| 130502 | TTC32 | P22T-E | Human | Esophagus | ESCC | 3.86e-26 | 4.02e-01 | 0.1236 |
| 130502 | TTC32 | P23T-E | Human | Esophagus | ESCC | 3.13e-15 | 4.72e-01 | 0.108 |
| 130502 | TTC32 | P24T-E | Human | Esophagus | ESCC | 1.30e-09 | 1.93e-01 | 0.1287 |
| 130502 | TTC32 | P26T-E | Human | Esophagus | ESCC | 3.23e-29 | 5.35e-01 | 0.1276 |
| 130502 | TTC32 | P27T-E | Human | Esophagus | ESCC | 1.00e-20 | 4.16e-01 | 0.1055 |
| 130502 | TTC32 | P28T-E | Human | Esophagus | ESCC | 3.08e-20 | 3.32e-01 | 0.1149 |
| 130502 | TTC32 | P30T-E | Human | Esophagus | ESCC | 5.33e-15 | 4.95e-01 | 0.137 |
| 130502 | TTC32 | P31T-E | Human | Esophagus | ESCC | 7.03e-08 | 1.25e-01 | 0.1251 |
| 130502 | TTC32 | P32T-E | Human | Esophagus | ESCC | 1.52e-14 | 2.78e-01 | 0.1666 |
| 130502 | TTC32 | P36T-E | Human | Esophagus | ESCC | 3.70e-14 | 3.64e-01 | 0.1187 |
| 130502 | TTC32 | P37T-E | Human | Esophagus | ESCC | 8.46e-11 | 2.04e-01 | 0.1371 |
| 130502 | TTC32 | P39T-E | Human | Esophagus | ESCC | 1.70e-10 | 1.64e-01 | 0.0894 |
| 130502 | TTC32 | P40T-E | Human | Esophagus | ESCC | 2.01e-04 | 8.85e-02 | 0.109 |
| 130502 | TTC32 | P42T-E | Human | Esophagus | ESCC | 4.16e-07 | 1.67e-01 | 0.1175 |
| 130502 | TTC32 | P44T-E | Human | Esophagus | ESCC | 6.82e-05 | 7.79e-02 | 0.1096 |
| 130502 | TTC32 | P47T-E | Human | Esophagus | ESCC | 8.51e-13 | 2.06e-01 | 0.1067 |
| 130502 | TTC32 | P48T-E | Human | Esophagus | ESCC | 2.62e-22 | 3.55e-01 | 0.0959 |
| 130502 | TTC32 | P49T-E | Human | Esophagus | ESCC | 5.78e-05 | 6.06e-01 | 0.1768 |
| 130502 | TTC32 | P52T-E | Human | Esophagus | ESCC | 2.20e-16 | 3.34e-01 | 0.1555 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TTC32 | insertion | Frame_Shift_Ins | novel | c.9_10insTTCGCCGGTGCGCTTGCGCGGCCTC | p.Gln4PhefsTer60 | p.Q4Ffs*60 | Q5I0X7 | protein_coding | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
| TTC32 | insertion | Frame_Shift_Ins | novel | c.8_9insCACTGTACTCCGCTTAC | p.Gln4ThrfsTer15 | p.Q4Tfs*15 | Q5I0X7 | protein_coding | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
| TTC32 | SNV | Missense_Mutation | rs748980235 | c.50N>T | p.Ala17Val | p.A17V | Q5I0X7 | protein_coding | tolerated(0.06) | possibly_damaging(0.741) | TCGA-AA-3955-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | capecitabine | CR |
| TTC32 | SNV | Missense_Mutation | c.323N>G | p.Phe108Cys | p.F108C | Q5I0X7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CA-5254-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
| TTC32 | SNV | Missense_Mutation | novel | c.143C>A | p.Pro48His | p.P48H | Q5I0X7 | protein_coding | tolerated(0.15) | benign(0) | TCGA-AP-A1DR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
| TTC32 | SNV | Missense_Mutation | c.431N>T | p.Arg144Ile | p.R144I | Q5I0X7 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| TTC32 | SNV | Missense_Mutation | c.68A>C | p.Glu23Ala | p.E23A | Q5I0X7 | protein_coding | tolerated(0.25) | benign(0.007) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| TTC32 | SNV | Missense_Mutation | rs751251296 | c.307N>C | p.Tyr103His | p.Y103H | Q5I0X7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TTC32 | insertion | Frame_Shift_Ins | novel | c.426dupA | p.Gln143ThrfsTer15 | p.Q143Tfs*15 | Q5I0X7 | protein_coding | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
| TTC32 | SNV | Missense_Mutation | rs149286415 | c.326A>T | p.Asp109Val | p.D109V | Q5I0X7 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-50-5051-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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