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Gene: TSSC1 |
Gene summary for TSSC1 |
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Gene information | Species | Human | Gene symbol | TSSC1 | Gene ID | 7260 |
Gene name | EARP complex and GARP complex interacting protein 1 | |
Gene Alias | EIPR-1 | |
Cytomap | 2p25.3 | |
Gene Type | protein-coding | GO ID | GO:0002790 | UniProtAcc | A8MUM1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7260 | TSSC1 | P21T-E | Human | Esophagus | ESCC | 3.40e-23 | 4.77e-01 | 0.1617 |
7260 | TSSC1 | P22T-E | Human | Esophagus | ESCC | 3.38e-26 | 4.45e-01 | 0.1236 |
7260 | TSSC1 | P23T-E | Human | Esophagus | ESCC | 1.21e-18 | 3.77e-01 | 0.108 |
7260 | TSSC1 | P24T-E | Human | Esophagus | ESCC | 1.35e-22 | 4.67e-01 | 0.1287 |
7260 | TSSC1 | P26T-E | Human | Esophagus | ESCC | 2.44e-28 | 5.32e-01 | 0.1276 |
7260 | TSSC1 | P27T-E | Human | Esophagus | ESCC | 2.80e-35 | 5.44e-01 | 0.1055 |
7260 | TSSC1 | P28T-E | Human | Esophagus | ESCC | 2.50e-27 | 4.75e-01 | 0.1149 |
7260 | TSSC1 | P30T-E | Human | Esophagus | ESCC | 3.41e-26 | 9.14e-01 | 0.137 |
7260 | TSSC1 | P31T-E | Human | Esophagus | ESCC | 1.80e-20 | 3.38e-01 | 0.1251 |
7260 | TSSC1 | P32T-E | Human | Esophagus | ESCC | 5.49e-24 | 4.28e-01 | 0.1666 |
7260 | TSSC1 | P36T-E | Human | Esophagus | ESCC | 1.55e-14 | 3.93e-01 | 0.1187 |
7260 | TSSC1 | P37T-E | Human | Esophagus | ESCC | 6.42e-15 | 3.26e-01 | 0.1371 |
7260 | TSSC1 | P38T-E | Human | Esophagus | ESCC | 1.70e-03 | 1.90e-01 | 0.127 |
7260 | TSSC1 | P39T-E | Human | Esophagus | ESCC | 1.21e-20 | 3.71e-01 | 0.0894 |
7260 | TSSC1 | P40T-E | Human | Esophagus | ESCC | 5.03e-07 | 2.31e-01 | 0.109 |
7260 | TSSC1 | P42T-E | Human | Esophagus | ESCC | 2.04e-14 | 4.47e-01 | 0.1175 |
7260 | TSSC1 | P44T-E | Human | Esophagus | ESCC | 1.14e-11 | 2.82e-01 | 0.1096 |
7260 | TSSC1 | P47T-E | Human | Esophagus | ESCC | 8.36e-18 | 1.65e-01 | 0.1067 |
7260 | TSSC1 | P48T-E | Human | Esophagus | ESCC | 1.54e-19 | 3.65e-01 | 0.0959 |
7260 | TSSC1 | P49T-E | Human | Esophagus | ESCC | 6.37e-17 | 1.10e+00 | 0.1768 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSSC1 | SNV | Missense_Mutation | c.385N>T | p.Pro129Ser | p.P129S | protein_coding | tolerated(0.05) | benign(0.177) | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
TSSC1 | SNV | Missense_Mutation | c.560T>C | p.Leu187Pro | p.L187P | protein_coding | tolerated(0.09) | benign(0.445) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TSSC1 | SNV | Missense_Mutation | novel | c.1186N>A | p.Asp396Asn | p.D396N | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
TSSC1 | SNV | Missense_Mutation | novel | c.500N>C | p.Val167Ala | p.V167A | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TSSC1 | SNV | Missense_Mutation | novel | c.301N>T | p.Gly101Trp | p.G101W | protein_coding | deleterious_low_confidence(0.03) | benign(0.017) | TCGA-PL-A8LV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TSSC1 | insertion | Nonsense_Mutation | novel | c.864_865insCATCACTAGGGG | p.Val288_Thr289insHisHisTerGly | p.V288_T289insHH*G | protein_coding | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
TSSC1 | SNV | Missense_Mutation | rs766526306 | c.916C>T | p.Arg306Cys | p.R306C | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TSSC1 | SNV | Missense_Mutation | rs376448610 | c.547N>A | p.Asp183Asn | p.D183N | protein_coding | tolerated(0.05) | benign(0.111) | TCGA-C5-A7CH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | SD | ||
TSSC1 | SNV | Missense_Mutation | novel | c.4G>C | p.Glu2Gln | p.E2Q | protein_coding | deleterious(0.01) | possibly_damaging(0.551) | TCGA-VS-A9UI-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
TSSC1 | SNV | Missense_Mutation | novel | c.691N>A | p.Ala231Thr | p.A231T | protein_coding | deleterious(0.01) | benign(0.17) | TCGA-ZJ-AAXI-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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