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Gene: TSPAN6 |
Gene summary for TSPAN6 |
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Gene information | Species | Human | Gene symbol | TSPAN6 | Gene ID | 7105 |
Gene name | tetraspanin 6 | |
Gene Alias | T245 | |
Cytomap | Xq22.1 | |
Gene Type | protein-coding | GO ID | GO:0002221 | UniProtAcc | A0A024RCI0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7105 | TSPAN6 | P9T-E | Human | Esophagus | ESCC | 4.52e-11 | 4.44e-01 | 0.1131 |
7105 | TSPAN6 | P10T-E | Human | Esophagus | ESCC | 2.89e-38 | 7.98e-01 | 0.116 |
7105 | TSPAN6 | P11T-E | Human | Esophagus | ESCC | 4.92e-07 | 6.25e-01 | 0.1426 |
7105 | TSPAN6 | P12T-E | Human | Esophagus | ESCC | 2.72e-34 | 8.24e-01 | 0.1122 |
7105 | TSPAN6 | P15T-E | Human | Esophagus | ESCC | 1.18e-25 | 7.82e-01 | 0.1149 |
7105 | TSPAN6 | P16T-E | Human | Esophagus | ESCC | 7.49e-35 | 7.28e-01 | 0.1153 |
7105 | TSPAN6 | P17T-E | Human | Esophagus | ESCC | 2.25e-03 | 3.48e-01 | 0.1278 |
7105 | TSPAN6 | P20T-E | Human | Esophagus | ESCC | 1.11e-23 | 3.73e-01 | 0.1124 |
7105 | TSPAN6 | P21T-E | Human | Esophagus | ESCC | 2.22e-09 | 4.16e-01 | 0.1617 |
7105 | TSPAN6 | P22T-E | Human | Esophagus | ESCC | 3.19e-32 | 5.88e-01 | 0.1236 |
7105 | TSPAN6 | P23T-E | Human | Esophagus | ESCC | 1.16e-34 | 1.38e+00 | 0.108 |
7105 | TSPAN6 | P24T-E | Human | Esophagus | ESCC | 1.02e-15 | 2.35e-01 | 0.1287 |
7105 | TSPAN6 | P26T-E | Human | Esophagus | ESCC | 1.59e-68 | 1.27e+00 | 0.1276 |
7105 | TSPAN6 | P27T-E | Human | Esophagus | ESCC | 2.65e-19 | 5.28e-01 | 0.1055 |
7105 | TSPAN6 | P28T-E | Human | Esophagus | ESCC | 4.10e-19 | 4.13e-01 | 0.1149 |
7105 | TSPAN6 | P30T-E | Human | Esophagus | ESCC | 2.53e-22 | 9.36e-01 | 0.137 |
7105 | TSPAN6 | P31T-E | Human | Esophagus | ESCC | 1.09e-37 | 8.44e-01 | 0.1251 |
7105 | TSPAN6 | P32T-E | Human | Esophagus | ESCC | 8.30e-30 | 8.80e-01 | 0.1666 |
7105 | TSPAN6 | P36T-E | Human | Esophagus | ESCC | 7.69e-12 | 5.78e-01 | 0.1187 |
7105 | TSPAN6 | P37T-E | Human | Esophagus | ESCC | 7.64e-34 | 8.68e-01 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030522 | Colorectum | AD | intracellular receptor signaling pathway | 87/3918 | 265/18723 | 3.69e-06 | 1.03e-04 | 87 |
GO:0043123 | Colorectum | AD | positive regulation of I-kappaB kinase/NF-kappaB signaling | 60/3918 | 186/18723 | 1.91e-04 | 2.56e-03 | 60 |
GO:0043122 | Colorectum | AD | regulation of I-kappaB kinase/NF-kappaB signaling | 76/3918 | 249/18723 | 2.17e-04 | 2.85e-03 | 76 |
GO:0007249 | Colorectum | AD | I-kappaB kinase/NF-kappaB signaling | 82/3918 | 281/18723 | 6.09e-04 | 6.40e-03 | 82 |
GO:00305222 | Colorectum | MSS | intracellular receptor signaling pathway | 84/3467 | 265/18723 | 1.47e-07 | 6.79e-06 | 84 |
GO:00431221 | Colorectum | MSS | regulation of I-kappaB kinase/NF-kappaB signaling | 71/3467 | 249/18723 | 7.12e-05 | 1.21e-03 | 71 |
GO:00072491 | Colorectum | MSS | I-kappaB kinase/NF-kappaB signaling | 77/3467 | 281/18723 | 1.51e-04 | 2.19e-03 | 77 |
GO:00431231 | Colorectum | MSS | positive regulation of I-kappaB kinase/NF-kappaB signaling | 55/3467 | 186/18723 | 1.60e-04 | 2.29e-03 | 55 |
GO:0002221 | Colorectum | MSS | pattern recognition receptor signaling pathway | 45/3467 | 172/18723 | 8.06e-03 | 4.91e-02 | 45 |
GO:00305223 | Colorectum | FAP | intracellular receptor signaling pathway | 67/2622 | 265/18723 | 6.84e-07 | 3.28e-05 | 67 |
GO:00431222 | Colorectum | FAP | regulation of I-kappaB kinase/NF-kappaB signaling | 56/2622 | 249/18723 | 1.82e-04 | 2.69e-03 | 56 |
GO:00431232 | Colorectum | FAP | positive regulation of I-kappaB kinase/NF-kappaB signaling | 42/2622 | 186/18723 | 1.01e-03 | 9.89e-03 | 42 |
GO:00072492 | Colorectum | FAP | I-kappaB kinase/NF-kappaB signaling | 58/2622 | 281/18723 | 1.37e-03 | 1.24e-02 | 58 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:004312318 | Esophagus | ESCC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 132/8552 | 186/18723 | 2.07e-12 | 8.58e-11 | 132 |
GO:0043122110 | Esophagus | ESCC | regulation of I-kappaB kinase/NF-kappaB signaling | 167/8552 | 249/18723 | 6.11e-12 | 2.32e-10 | 167 |
GO:000724919 | Esophagus | ESCC | I-kappaB kinase/NF-kappaB signaling | 183/8552 | 281/18723 | 3.02e-11 | 1.01e-09 | 183 |
GO:00516075 | Esophagus | ESCC | defense response to virus | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:01405465 | Esophagus | ESCC | defense response to symbiont | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:0030522110 | Esophagus | ESCC | intracellular receptor signaling pathway | 170/8552 | 265/18723 | 8.58e-10 | 2.09e-08 | 170 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSPAN6 | SNV | Missense_Mutation | novel | c.251N>A | p.Arg84Gln | p.R84Q | O43657 | protein_coding | deleterious(0.05) | benign(0.054) | TCGA-E9-A5FL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TSPAN6 | SNV | Missense_Mutation | novel | c.349N>A | p.Glu117Lys | p.E117K | O43657 | protein_coding | tolerated(0.3) | benign(0.163) | TCGA-VS-A9UD-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
TSPAN6 | SNV | Missense_Mutation | novel | c.89N>C | p.Ile30Thr | p.I30T | O43657 | protein_coding | deleterious(0) | possibly_damaging(0.77) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TSPAN6 | SNV | Missense_Mutation | c.59N>C | p.Val20Ala | p.V20A | O43657 | protein_coding | deleterious(0.01) | benign(0.015) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
TSPAN6 | SNV | Missense_Mutation | c.386N>A | p.Ala129Asp | p.A129D | O43657 | protein_coding | deleterious(0.03) | benign(0.156) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
TSPAN6 | SNV | Missense_Mutation | novel | c.618G>T | p.Glu206Asp | p.E206D | O43657 | protein_coding | tolerated(0.08) | benign(0.378) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TSPAN6 | SNV | Missense_Mutation | c.364N>G | p.Phe122Val | p.F122V | O43657 | protein_coding | deleterious(0) | possibly_damaging(0.741) | TCGA-A5-A0GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TSPAN6 | SNV | Missense_Mutation | rs371334172 | c.620N>T | p.Ser207Leu | p.S207L | O43657 | protein_coding | deleterious(0.02) | possibly_damaging(0.806) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TSPAN6 | SNV | Missense_Mutation | c.136N>G | p.Leu46Val | p.L46V | O43657 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-AJ-A23M-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | unknown | PD | |
TSPAN6 | SNV | Missense_Mutation | rs745504645 | c.704N>A | p.Arg235His | p.R235H | O43657 | protein_coding | deleterious(0.04) | benign(0.031) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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