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Gene: TRMT11 |
Gene summary for TRMT11 |
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Gene information | Species | Human | Gene symbol | TRMT11 | Gene ID | 60487 |
Gene name | tRNA methyltransferase 11 homolog | |
Gene Alias | C6orf75 | |
Cytomap | 6q22.32 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | Q7Z4G4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
60487 | TRMT11 | P22T-E | Human | Esophagus | ESCC | 3.44e-05 | 5.01e-02 | 0.1236 |
60487 | TRMT11 | P23T-E | Human | Esophagus | ESCC | 1.66e-06 | 1.83e-01 | 0.108 |
60487 | TRMT11 | P24T-E | Human | Esophagus | ESCC | 2.77e-11 | 2.47e-01 | 0.1287 |
60487 | TRMT11 | P26T-E | Human | Esophagus | ESCC | 7.19e-15 | 1.91e-01 | 0.1276 |
60487 | TRMT11 | P27T-E | Human | Esophagus | ESCC | 1.58e-07 | 1.88e-01 | 0.1055 |
60487 | TRMT11 | P28T-E | Human | Esophagus | ESCC | 1.45e-14 | 1.83e-01 | 0.1149 |
60487 | TRMT11 | P30T-E | Human | Esophagus | ESCC | 1.11e-09 | 4.21e-01 | 0.137 |
60487 | TRMT11 | P31T-E | Human | Esophagus | ESCC | 3.97e-12 | 1.48e-01 | 0.1251 |
60487 | TRMT11 | P32T-E | Human | Esophagus | ESCC | 6.19e-11 | 1.63e-01 | 0.1666 |
60487 | TRMT11 | P36T-E | Human | Esophagus | ESCC | 2.05e-15 | 2.73e-01 | 0.1187 |
60487 | TRMT11 | P37T-E | Human | Esophagus | ESCC | 1.95e-24 | 2.92e-01 | 0.1371 |
60487 | TRMT11 | P38T-E | Human | Esophagus | ESCC | 8.98e-07 | 1.46e-01 | 0.127 |
60487 | TRMT11 | P39T-E | Human | Esophagus | ESCC | 1.55e-10 | 9.71e-02 | 0.0894 |
60487 | TRMT11 | P40T-E | Human | Esophagus | ESCC | 1.02e-03 | 1.29e-01 | 0.109 |
60487 | TRMT11 | P42T-E | Human | Esophagus | ESCC | 3.24e-08 | 1.29e-01 | 0.1175 |
60487 | TRMT11 | P44T-E | Human | Esophagus | ESCC | 5.49e-09 | 1.42e-01 | 0.1096 |
60487 | TRMT11 | P47T-E | Human | Esophagus | ESCC | 1.59e-04 | 4.66e-02 | 0.1067 |
60487 | TRMT11 | P48T-E | Human | Esophagus | ESCC | 8.28e-12 | 1.23e-01 | 0.0959 |
60487 | TRMT11 | P49T-E | Human | Esophagus | ESCC | 1.18e-07 | 8.26e-01 | 0.1768 |
60487 | TRMT11 | P52T-E | Human | Esophagus | ESCC | 4.16e-17 | 3.05e-01 | 0.1555 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00226139 | Breast | Precancer | ribonucleoprotein complex biogenesis | 79/1080 | 463/18723 | 2.11e-18 | 1.03e-15 | 79 |
GO:00422549 | Breast | Precancer | ribosome biogenesis | 52/1080 | 299/18723 | 7.35e-13 | 1.51e-10 | 52 |
GO:00063646 | Breast | Precancer | rRNA processing | 35/1080 | 225/18723 | 7.90e-08 | 4.60e-06 | 35 |
GO:00160726 | Breast | Precancer | rRNA metabolic process | 36/1080 | 236/18723 | 8.59e-08 | 4.84e-06 | 36 |
GO:00344705 | Breast | Precancer | ncRNA processing | 42/1080 | 395/18723 | 9.91e-05 | 1.83e-03 | 42 |
GO:00346604 | Breast | Precancer | ncRNA metabolic process | 45/1080 | 485/18723 | 1.15e-03 | 1.26e-02 | 45 |
GO:002261314 | Breast | IDC | ribonucleoprotein complex biogenesis | 83/1434 | 463/18723 | 2.01e-13 | 5.20e-11 | 83 |
GO:004225414 | Breast | IDC | ribosome biogenesis | 52/1434 | 299/18723 | 1.90e-08 | 1.32e-06 | 52 |
GO:000636414 | Breast | IDC | rRNA processing | 35/1434 | 225/18723 | 4.59e-05 | 1.03e-03 | 35 |
GO:001607214 | Breast | IDC | rRNA metabolic process | 36/1434 | 236/18723 | 5.48e-05 | 1.17e-03 | 36 |
GO:002261324 | Breast | DCIS | ribonucleoprotein complex biogenesis | 83/1390 | 463/18723 | 3.65e-14 | 1.09e-11 | 83 |
GO:004225423 | Breast | DCIS | ribosome biogenesis | 52/1390 | 299/18723 | 6.73e-09 | 5.44e-07 | 52 |
GO:000636422 | Breast | DCIS | rRNA processing | 35/1390 | 225/18723 | 2.41e-05 | 5.62e-04 | 35 |
GO:001607222 | Breast | DCIS | rRNA metabolic process | 36/1390 | 236/18723 | 2.86e-05 | 6.42e-04 | 36 |
GO:003447011 | Breast | DCIS | ncRNA processing | 44/1390 | 395/18723 | 4.56e-03 | 3.49e-02 | 44 |
GO:002261310 | Cervix | CC | ribonucleoprotein complex biogenesis | 88/2311 | 463/18723 | 2.11e-05 | 3.82e-04 | 88 |
GO:004225410 | Cervix | CC | ribosome biogenesis | 62/2311 | 299/18723 | 2.48e-05 | 4.27e-04 | 62 |
GO:00165705 | Cervix | CC | histone modification | 84/2311 | 463/18723 | 1.70e-04 | 2.01e-03 | 84 |
GO:00349685 | Cervix | CC | histone lysine methylation | 27/2311 | 115/18723 | 6.61e-04 | 6.09e-03 | 27 |
GO:00165715 | Cervix | CC | histone methylation | 30/2311 | 141/18723 | 1.88e-03 | 1.39e-02 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRMT11 | SNV | Missense_Mutation | c.317N>T | p.Ser106Phe | p.S106F | Q7Z4G4 | protein_coding | tolerated(0.07) | benign(0.153) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
TRMT11 | SNV | Missense_Mutation | rs759177203 | c.824G>A | p.Arg275His | p.R275H | Q7Z4G4 | protein_coding | tolerated(0.12) | probably_damaging(0.986) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TRMT11 | SNV | Missense_Mutation | rs144488568 | c.380G>A | p.Arg127Gln | p.R127Q | Q7Z4G4 | protein_coding | deleterious(0.02) | benign(0.322) | TCGA-ZX-AA5X-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
TRMT11 | SNV | Missense_Mutation | c.367G>A | p.Glu123Lys | p.E123K | Q7Z4G4 | protein_coding | tolerated(0.11) | benign(0.077) | TCGA-A6-2677-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Ancillary | leucovorin | SD | |
TRMT11 | SNV | Missense_Mutation | c.429N>T | p.Lys143Asn | p.K143N | Q7Z4G4 | protein_coding | tolerated(0.18) | possibly_damaging(0.466) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TRMT11 | SNV | Missense_Mutation | novel | c.333N>T | p.Lys111Asn | p.K111N | Q7Z4G4 | protein_coding | tolerated(0.61) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TRMT11 | SNV | Missense_Mutation | c.167C>A | p.Ser56Tyr | p.S56Y | Q7Z4G4 | protein_coding | deleterious(0.04) | possibly_damaging(0.87) | TCGA-DC-5869-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TRMT11 | SNV | Missense_Mutation | c.923N>T | p.Asp308Val | p.D308V | Q7Z4G4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0GW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TRMT11 | SNV | Missense_Mutation | novel | c.185N>C | p.Asn62Thr | p.N62T | Q7Z4G4 | protein_coding | tolerated(0.35) | benign(0.052) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRMT11 | SNV | Missense_Mutation | novel | c.219A>G | p.Ile73Met | p.I73M | Q7Z4G4 | protein_coding | tolerated(0.16) | benign(0.097) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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