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Gene: TRABD |
Gene summary for TRABD |
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Gene information | Species | Human | Gene symbol | TRABD | Gene ID | 80305 |
Gene name | TraB domain containing | |
Gene Alias | LP6054 | |
Cytomap | 22q13.33 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q9H4I3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80305 | TRABD | P17T-E | Human | Esophagus | ESCC | 1.02e-12 | 8.21e-01 | 0.1278 |
80305 | TRABD | P19T-E | Human | Esophagus | ESCC | 7.52e-11 | 9.61e-01 | 0.1662 |
80305 | TRABD | P20T-E | Human | Esophagus | ESCC | 1.04e-30 | 4.98e-01 | 0.1124 |
80305 | TRABD | P21T-E | Human | Esophagus | ESCC | 5.36e-31 | 6.77e-01 | 0.1617 |
80305 | TRABD | P22T-E | Human | Esophagus | ESCC | 4.30e-53 | 9.57e-01 | 0.1236 |
80305 | TRABD | P23T-E | Human | Esophagus | ESCC | 1.66e-23 | 5.57e-01 | 0.108 |
80305 | TRABD | P24T-E | Human | Esophagus | ESCC | 4.37e-29 | 7.42e-01 | 0.1287 |
80305 | TRABD | P26T-E | Human | Esophagus | ESCC | 1.18e-52 | 1.01e+00 | 0.1276 |
80305 | TRABD | P27T-E | Human | Esophagus | ESCC | 9.50e-40 | 6.28e-01 | 0.1055 |
80305 | TRABD | P28T-E | Human | Esophagus | ESCC | 1.77e-37 | 7.06e-01 | 0.1149 |
80305 | TRABD | P30T-E | Human | Esophagus | ESCC | 1.01e-44 | 1.64e+00 | 0.137 |
80305 | TRABD | P31T-E | Human | Esophagus | ESCC | 8.97e-33 | 4.80e-01 | 0.1251 |
80305 | TRABD | P32T-E | Human | Esophagus | ESCC | 1.44e-44 | 9.99e-01 | 0.1666 |
80305 | TRABD | P36T-E | Human | Esophagus | ESCC | 1.49e-25 | 7.92e-01 | 0.1187 |
80305 | TRABD | P37T-E | Human | Esophagus | ESCC | 8.71e-32 | 8.03e-01 | 0.1371 |
80305 | TRABD | P39T-E | Human | Esophagus | ESCC | 1.68e-25 | 4.40e-01 | 0.0894 |
80305 | TRABD | P40T-E | Human | Esophagus | ESCC | 5.06e-20 | 7.84e-01 | 0.109 |
80305 | TRABD | P42T-E | Human | Esophagus | ESCC | 9.74e-35 | 8.20e-01 | 0.1175 |
80305 | TRABD | P44T-E | Human | Esophagus | ESCC | 3.46e-13 | 2.73e-01 | 0.1096 |
80305 | TRABD | P47T-E | Human | Esophagus | ESCC | 1.38e-17 | 4.59e-01 | 0.1067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0031334 | Colorectum | AD | positive regulation of protein-containing complex assembly | 91/3918 | 237/18723 | 4.78e-10 | 3.99e-08 | 91 |
GO:0030111 | Colorectum | AD | regulation of Wnt signaling pathway | 102/3918 | 328/18723 | 8.51e-06 | 2.03e-04 | 102 |
GO:0016055 | Colorectum | AD | Wnt signaling pathway | 130/3918 | 444/18723 | 1.60e-05 | 3.37e-04 | 130 |
GO:0198738 | Colorectum | AD | cell-cell signaling by wnt | 130/3918 | 446/18723 | 2.02e-05 | 4.10e-04 | 130 |
GO:00432541 | Colorectum | SER | regulation of protein-containing complex assembly | 119/2897 | 428/18723 | 3.34e-11 | 5.86e-09 | 119 |
GO:00313341 | Colorectum | SER | positive regulation of protein-containing complex assembly | 73/2897 | 237/18723 | 1.89e-09 | 1.84e-07 | 73 |
GO:00160551 | Colorectum | SER | Wnt signaling pathway | 97/2897 | 444/18723 | 2.02e-04 | 3.68e-03 | 97 |
GO:01987381 | Colorectum | SER | cell-cell signaling by wnt | 97/2897 | 446/18723 | 2.39e-04 | 4.11e-03 | 97 |
GO:00301111 | Colorectum | SER | regulation of Wnt signaling pathway | 75/2897 | 328/18723 | 2.47e-04 | 4.20e-03 | 75 |
GO:00432542 | Colorectum | MSS | regulation of protein-containing complex assembly | 130/3467 | 428/18723 | 1.38e-09 | 1.03e-07 | 130 |
GO:00313342 | Colorectum | MSS | positive regulation of protein-containing complex assembly | 82/3467 | 237/18723 | 2.49e-09 | 1.75e-07 | 82 |
GO:00301112 | Colorectum | MSS | regulation of Wnt signaling pathway | 98/3467 | 328/18723 | 3.37e-07 | 1.36e-05 | 98 |
GO:00160552 | Colorectum | MSS | Wnt signaling pathway | 124/3467 | 444/18723 | 6.06e-07 | 2.26e-05 | 124 |
GO:01987382 | Colorectum | MSS | cell-cell signaling by wnt | 124/3467 | 446/18723 | 7.83e-07 | 2.77e-05 | 124 |
GO:0030178 | Colorectum | MSS | negative regulation of Wnt signaling pathway | 48/3467 | 170/18723 | 1.23e-03 | 1.18e-02 | 48 |
GO:00160553 | Colorectum | FAP | Wnt signaling pathway | 104/2622 | 444/18723 | 4.92e-08 | 3.92e-06 | 104 |
GO:00432544 | Colorectum | FAP | regulation of protein-containing complex assembly | 101/2622 | 428/18723 | 5.18e-08 | 4.07e-06 | 101 |
GO:01987383 | Colorectum | FAP | cell-cell signaling by wnt | 104/2622 | 446/18723 | 6.26e-08 | 4.54e-06 | 104 |
GO:00301113 | Colorectum | FAP | regulation of Wnt signaling pathway | 81/2622 | 328/18723 | 1.44e-07 | 9.03e-06 | 81 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRABD | SNV | Missense_Mutation | c.205N>T | p.Ala69Ser | p.A69S | protein_coding | tolerated(0.13) | benign(0.053) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | ||
TRABD | SNV | Missense_Mutation | c.703N>A | p.Asp235Asn | p.D235N | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
TRABD | SNV | Missense_Mutation | rs374922285 | c.862N>A | p.Val288Ile | p.V288I | protein_coding | tolerated(0.32) | benign(0.005) | TCGA-A6-5657-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD | |
TRABD | SNV | Missense_Mutation | novel | c.370C>T | p.Arg124Trp | p.R124W | protein_coding | deleterious(0) | possibly_damaging(0.663) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TRABD | SNV | Missense_Mutation | c.886G>A | p.Val296Met | p.V296M | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TRABD | SNV | Missense_Mutation | c.707N>C | p.Leu236Pro | p.L236P | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
TRABD | SNV | Missense_Mutation | c.725N>T | p.Ala242Val | p.A242V | protein_coding | deleterious(0.01) | benign(0.444) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
TRABD | SNV | Missense_Mutation | rs761422252 | c.1084N>A | p.Ala362Thr | p.A362T | protein_coding | tolerated(0.18) | benign(0.022) | TCGA-AF-A56N-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
TRABD | SNV | Missense_Mutation | novel | c.105N>T | p.Gln35His | p.Q35H | protein_coding | tolerated_low_confidence(0.11) | benign(0.067) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TRABD | SNV | Missense_Mutation | novel | c.821N>C | p.Leu274Pro | p.L274P | protein_coding | tolerated(0.18) | benign(0.017) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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