Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/TNFRSF10D_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/TNFRSF10D_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/TNFRSF10D_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNFRSF10D | SNV | Missense_Mutation | novel | c.767N>A | p.Arg256Lys | p.R256K | Q9UBN6 | protein_coding | tolerated(0.31) | possibly_damaging(0.826) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
TNFRSF10D | SNV | Missense_Mutation | | c.968N>A | p.Ala323Asp | p.A323D | Q9UBN6 | protein_coding | tolerated(0.37) | possibly_damaging(0.9) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TNFRSF10D | SNV | Missense_Mutation | | c.31G>A | p.Ala11Thr | p.A11T | Q9UBN6 | protein_coding | tolerated(0.19) | benign(0.021) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TNFRSF10D | SNV | Missense_Mutation | rs373138944 | c.1148N>T | p.Thr383Met | p.T383M | Q9UBN6 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.832) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TNFRSF10D | SNV | Missense_Mutation | | c.541N>G | p.Lys181Glu | p.K181E | Q9UBN6 | protein_coding | tolerated(0.74) | benign(0.09) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TNFRSF10D | SNV | Missense_Mutation | novel | c.1156C>A | p.Leu386Met | p.L386M | Q9UBN6 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TNFRSF10D | SNV | Missense_Mutation | novel | c.506T>C | p.Val169Ala | p.V169A | Q9UBN6 | protein_coding | tolerated(0.69) | benign(0.308) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TNFRSF10D | SNV | Missense_Mutation | novel | c.183G>T | p.Gln61His | p.Q61H | Q9UBN6 | protein_coding | tolerated(0.05) | possibly_damaging(0.799) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TNFRSF10D | SNV | Missense_Mutation | rs148918013 | c.947G>A | p.Arg316His | p.R316H | Q9UBN6 | protein_coding | tolerated(0.81) | benign(0.003) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TNFRSF10D | SNV | Missense_Mutation | | c.818N>G | p.Asp273Gly | p.D273G | Q9UBN6 | protein_coding | deleterious(0.05) | probably_damaging(0.967) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |