![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TMEM39A |
Gene summary for TMEM39A |
![]() |
Gene information | Species | Human | Gene symbol | TMEM39A | Gene ID | 55254 |
Gene name | transmembrane protein 39A | |
Gene Alias | SUSR2 | |
Cytomap | 3q13.33 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q9NV64 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55254 | TMEM39A | P22T-E | Human | Esophagus | ESCC | 8.12e-25 | 4.69e-01 | 0.1236 |
55254 | TMEM39A | P23T-E | Human | Esophagus | ESCC | 4.93e-24 | 7.58e-01 | 0.108 |
55254 | TMEM39A | P24T-E | Human | Esophagus | ESCC | 2.73e-14 | 3.33e-01 | 0.1287 |
55254 | TMEM39A | P26T-E | Human | Esophagus | ESCC | 1.48e-36 | 6.08e-01 | 0.1276 |
55254 | TMEM39A | P27T-E | Human | Esophagus | ESCC | 2.76e-18 | 3.47e-01 | 0.1055 |
55254 | TMEM39A | P28T-E | Human | Esophagus | ESCC | 1.10e-10 | 2.46e-01 | 0.1149 |
55254 | TMEM39A | P30T-E | Human | Esophagus | ESCC | 1.25e-24 | 6.32e-01 | 0.137 |
55254 | TMEM39A | P31T-E | Human | Esophagus | ESCC | 1.82e-22 | 4.25e-01 | 0.1251 |
55254 | TMEM39A | P32T-E | Human | Esophagus | ESCC | 6.71e-24 | 5.70e-01 | 0.1666 |
55254 | TMEM39A | P36T-E | Human | Esophagus | ESCC | 4.05e-12 | 5.07e-01 | 0.1187 |
55254 | TMEM39A | P37T-E | Human | Esophagus | ESCC | 5.56e-15 | 3.74e-01 | 0.1371 |
55254 | TMEM39A | P38T-E | Human | Esophagus | ESCC | 2.35e-02 | 1.38e-01 | 0.127 |
55254 | TMEM39A | P39T-E | Human | Esophagus | ESCC | 1.49e-11 | 1.24e-01 | 0.0894 |
55254 | TMEM39A | P40T-E | Human | Esophagus | ESCC | 6.91e-05 | 2.87e-01 | 0.109 |
55254 | TMEM39A | P42T-E | Human | Esophagus | ESCC | 2.05e-04 | 3.69e-01 | 0.1175 |
55254 | TMEM39A | P44T-E | Human | Esophagus | ESCC | 1.42e-06 | 3.14e-01 | 0.1096 |
55254 | TMEM39A | P47T-E | Human | Esophagus | ESCC | 4.26e-18 | 3.83e-01 | 0.1067 |
55254 | TMEM39A | P48T-E | Human | Esophagus | ESCC | 2.17e-11 | 3.05e-01 | 0.0959 |
55254 | TMEM39A | P49T-E | Human | Esophagus | ESCC | 7.69e-12 | 9.33e-01 | 0.1768 |
55254 | TMEM39A | P52T-E | Human | Esophagus | ESCC | 4.08e-24 | 6.09e-01 | 0.1555 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032111 | Esophagus | ESCC | viral process | 301/8552 | 415/18723 | 3.34e-29 | 1.32e-26 | 301 |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:0019058111 | Esophagus | ESCC | viral life cycle | 226/8552 | 317/18723 | 1.17e-20 | 1.76e-18 | 226 |
GO:001050617 | Esophagus | ESCC | regulation of autophagy | 220/8552 | 317/18723 | 6.72e-18 | 6.36e-16 | 220 |
GO:0019079111 | Esophagus | ESCC | viral genome replication | 102/8552 | 131/18723 | 4.31e-14 | 2.19e-12 | 102 |
GO:0050792111 | Esophagus | ESCC | regulation of viral process | 119/8552 | 164/18723 | 2.19e-12 | 9.03e-11 | 119 |
GO:000703314 | Esophagus | ESCC | vacuole organization | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
GO:001624114 | Esophagus | ESCC | regulation of macroautophagy | 102/8552 | 141/18723 | 1.09e-10 | 3.27e-09 | 102 |
GO:1903900111 | Esophagus | ESCC | regulation of viral life cycle | 106/8552 | 148/18723 | 1.26e-10 | 3.72e-09 | 106 |
GO:0045069110 | Esophagus | ESCC | regulation of viral genome replication | 67/8552 | 85/18723 | 3.81e-10 | 1.04e-08 | 67 |
GO:0009895111 | Esophagus | ESCC | negative regulation of catabolic process | 201/8552 | 320/18723 | 3.88e-10 | 1.05e-08 | 201 |
GO:0010639110 | Esophagus | ESCC | negative regulation of organelle organization | 215/8552 | 348/18723 | 8.20e-10 | 2.01e-08 | 215 |
GO:0031330111 | Esophagus | ESCC | negative regulation of cellular catabolic process | 166/8552 | 262/18723 | 5.17e-09 | 1.08e-07 | 166 |
GO:0048524110 | Esophagus | ESCC | positive regulation of viral process | 52/8552 | 65/18723 | 1.41e-08 | 2.77e-07 | 52 |
GO:190503712 | Esophagus | ESCC | autophagosome organization | 73/8552 | 103/18723 | 1.88e-07 | 2.93e-06 | 73 |
GO:000004513 | Esophagus | ESCC | autophagosome assembly | 69/8552 | 99/18723 | 1.10e-06 | 1.38e-05 | 69 |
GO:190211514 | Esophagus | ESCC | regulation of organelle assembly | 116/8552 | 186/18723 | 3.15e-06 | 3.53e-05 | 116 |
GO:00973523 | Esophagus | ESCC | autophagosome maturation | 31/8552 | 40/18723 | 4.04e-05 | 3.26e-04 | 31 |
Page: 1 2 3 4 5 6 7 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM39A | insertion | Frame_Shift_Ins | novel | c.766_767insT | p.Thr256IlefsTer18 | p.T256Ifs*18 | Q9NV64 | protein_coding | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
TMEM39A | insertion | Frame_Shift_Ins | novel | c.765_766insTGCCTCCCTACTGT | p.Thr256CysfsTer24 | p.T256Cfs*24 | Q9NV64 | protein_coding | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
TMEM39A | deletion | Frame_Shift_Del | c.239delN | p.Phe80SerfsTer33 | p.F80Sfs*33 | Q9NV64 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
TMEM39A | insertion | Frame_Shift_Ins | novel | c.750_751insATACC | p.Gln251IlefsTer26 | p.Q251Ifs*26 | Q9NV64 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TMEM39A | deletion | Frame_Shift_Del | c.1185delN | p.Pro396LeufsTer23 | p.P396Lfs*23 | Q9NV64 | protein_coding | TCGA-E2-A14W-01 | Breast | breast invasive carcinoma | Male | >=65 | I/II | Chemotherapy | cytoxan | SD | |||
TMEM39A | SNV | Missense_Mutation | novel | c.812G>A | p.Arg271His | p.R271H | Q9NV64 | protein_coding | deleterious(0.04) | probably_damaging(0.995) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TMEM39A | SNV | Missense_Mutation | rs559521023 | c.536N>A | p.Arg179Gln | p.R179Q | Q9NV64 | protein_coding | tolerated(0.06) | benign(0.147) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMEM39A | SNV | Missense_Mutation | novel | c.146C>A | p.Pro49His | p.P49H | Q9NV64 | protein_coding | deleterious(0.01) | possibly_damaging(0.888) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM39A | SNV | Missense_Mutation | c.121N>G | p.Ser41Gly | p.S41G | Q9NV64 | protein_coding | tolerated(0.09) | benign(0.067) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM39A | deletion | Frame_Shift_Del | c.239delN | p.Phe80SerfsTer33 | p.F80Sfs*33 | Q9NV64 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |