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Gene: TMEM168 |
Gene summary for TMEM168 |
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Gene information | Species | Human | Gene symbol | TMEM168 | Gene ID | 64418 |
Gene name | transmembrane protein 168 | |
Gene Alias | TMEM168 | |
Cytomap | 7q31.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R716 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64418 | TMEM168 | A015-C-106 | Human | Colorectum | FAP | 1.31e-14 | -4.39e-01 | -0.0511 |
64418 | TMEM168 | A002-C-114 | Human | Colorectum | FAP | 1.54e-21 | -5.07e-01 | -0.1561 |
64418 | TMEM168 | A015-C-104 | Human | Colorectum | FAP | 1.18e-36 | -6.51e-01 | -0.1899 |
64418 | TMEM168 | A001-C-014 | Human | Colorectum | FAP | 1.98e-19 | -4.83e-01 | 0.0135 |
64418 | TMEM168 | A002-C-016 | Human | Colorectum | FAP | 2.06e-26 | -5.02e-01 | 0.0521 |
64418 | TMEM168 | A015-C-002 | Human | Colorectum | FAP | 1.07e-17 | -6.03e-01 | -0.0763 |
64418 | TMEM168 | A001-C-203 | Human | Colorectum | FAP | 6.30e-11 | -3.34e-01 | -0.0481 |
64418 | TMEM168 | A002-C-116 | Human | Colorectum | FAP | 1.13e-32 | -5.65e-01 | -0.0452 |
64418 | TMEM168 | A014-C-008 | Human | Colorectum | FAP | 2.25e-15 | -4.92e-01 | -0.191 |
64418 | TMEM168 | A018-E-020 | Human | Colorectum | FAP | 1.94e-20 | -3.82e-01 | -0.2034 |
64418 | TMEM168 | F034 | Human | Colorectum | FAP | 3.21e-23 | -5.39e-01 | -0.0665 |
64418 | TMEM168 | F072B | Human | Colorectum | FAP | 1.59e-06 | -2.17e-01 | 0.257 |
64418 | TMEM168 | CRC-3-11773 | Human | Colorectum | CRC | 3.91e-13 | -3.85e-01 | 0.2564 |
64418 | TMEM168 | LZE4T | Human | Esophagus | ESCC | 7.11e-05 | 1.56e-01 | 0.0811 |
64418 | TMEM168 | LZE24T | Human | Esophagus | ESCC | 5.65e-08 | 1.82e-01 | 0.0596 |
64418 | TMEM168 | LZE21T | Human | Esophagus | ESCC | 3.22e-02 | 1.50e-01 | 0.0655 |
64418 | TMEM168 | P1T-E | Human | Esophagus | ESCC | 2.37e-05 | 2.56e-01 | 0.0875 |
64418 | TMEM168 | P2T-E | Human | Esophagus | ESCC | 3.70e-12 | 2.00e-01 | 0.1177 |
64418 | TMEM168 | P4T-E | Human | Esophagus | ESCC | 4.80e-14 | 2.83e-01 | 0.1323 |
64418 | TMEM168 | P5T-E | Human | Esophagus | ESCC | 2.16e-06 | 1.15e-01 | 0.1327 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM168 | SNV | Missense_Mutation | novel | c.1715N>A | p.Ile572Lys | p.I572K | Q9H0V1 | protein_coding | tolerated(0.93) | benign(0) | TCGA-GI-A2C8-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | Adriamycin | SD |
TMEM168 | deletion | Frame_Shift_Del | novel | c.1815delN | p.Trp605Ter | p.W605* | Q9H0V1 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TMEM168 | SNV | Missense_Mutation | c.472N>A | p.Glu158Lys | p.E158K | Q9H0V1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-C5-A1BL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM168 | SNV | Missense_Mutation | c.1567G>A | p.Asp523Asn | p.D523N | Q9H0V1 | protein_coding | tolerated(0.22) | benign(0.121) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
TMEM168 | SNV | Missense_Mutation | c.1381G>A | p.Glu461Lys | p.E461K | Q9H0V1 | protein_coding | deleterious(0.01) | possibly_damaging(0.513) | TCGA-ZJ-AB0H-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
TMEM168 | SNV | Missense_Mutation | c.1671N>T | p.Arg557Ser | p.R557S | Q9H0V1 | protein_coding | deleterious(0.01) | benign(0.33) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM168 | SNV | Missense_Mutation | c.1114G>A | p.Ala372Thr | p.A372T | Q9H0V1 | protein_coding | deleterious(0.01) | possibly_damaging(0.907) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
TMEM168 | SNV | Missense_Mutation | rs745740456 | c.1456N>A | p.Glu486Lys | p.E486K | Q9H0V1 | protein_coding | deleterious(0.01) | benign(0.38) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TMEM168 | SNV | Missense_Mutation | novel | c.706G>A | p.Asp236Asn | p.D236N | Q9H0V1 | protein_coding | tolerated(0.06) | benign(0.012) | TCGA-AA-3867-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
TMEM168 | SNV | Missense_Mutation | rs777473488 | c.100C>T | p.Arg34Trp | p.R34W | Q9H0V1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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