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Gene: TMEM167B |
Gene summary for TMEM167B |
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Gene information | Species | Human | Gene symbol | TMEM167B | Gene ID | 56900 |
Gene name | transmembrane protein 167B | |
Gene Alias | AD-020 | |
Cytomap | 1p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9NRX6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56900 | TMEM167B | P21T-E | Human | Esophagus | ESCC | 1.11e-18 | 1.29e-01 | 0.1617 |
56900 | TMEM167B | P22T-E | Human | Esophagus | ESCC | 3.54e-09 | 8.31e-02 | 0.1236 |
56900 | TMEM167B | P23T-E | Human | Esophagus | ESCC | 1.09e-29 | 5.53e-01 | 0.108 |
56900 | TMEM167B | P24T-E | Human | Esophagus | ESCC | 2.15e-08 | 1.56e-01 | 0.1287 |
56900 | TMEM167B | P26T-E | Human | Esophagus | ESCC | 4.01e-21 | 3.47e-01 | 0.1276 |
56900 | TMEM167B | P27T-E | Human | Esophagus | ESCC | 9.63e-15 | 1.48e-01 | 0.1055 |
56900 | TMEM167B | P28T-E | Human | Esophagus | ESCC | 1.36e-18 | 2.58e-01 | 0.1149 |
56900 | TMEM167B | P30T-E | Human | Esophagus | ESCC | 3.92e-17 | 5.88e-01 | 0.137 |
56900 | TMEM167B | P31T-E | Human | Esophagus | ESCC | 4.26e-27 | 3.98e-01 | 0.1251 |
56900 | TMEM167B | P32T-E | Human | Esophagus | ESCC | 7.95e-34 | 5.83e-01 | 0.1666 |
56900 | TMEM167B | P36T-E | Human | Esophagus | ESCC | 3.06e-06 | 1.96e-01 | 0.1187 |
56900 | TMEM167B | P37T-E | Human | Esophagus | ESCC | 7.54e-14 | 2.85e-01 | 0.1371 |
56900 | TMEM167B | P38T-E | Human | Esophagus | ESCC | 7.06e-14 | 4.61e-01 | 0.127 |
56900 | TMEM167B | P39T-E | Human | Esophagus | ESCC | 2.84e-22 | 1.80e-01 | 0.0894 |
56900 | TMEM167B | P40T-E | Human | Esophagus | ESCC | 1.39e-09 | 2.12e-01 | 0.109 |
56900 | TMEM167B | P42T-E | Human | Esophagus | ESCC | 1.17e-18 | 3.58e-01 | 0.1175 |
56900 | TMEM167B | P44T-E | Human | Esophagus | ESCC | 1.63e-11 | 1.73e-01 | 0.1096 |
56900 | TMEM167B | P47T-E | Human | Esophagus | ESCC | 2.81e-18 | 2.27e-01 | 0.1067 |
56900 | TMEM167B | P48T-E | Human | Esophagus | ESCC | 1.09e-10 | 1.30e-01 | 0.0959 |
56900 | TMEM167B | P49T-E | Human | Esophagus | ESCC | 6.01e-11 | 7.55e-01 | 0.1768 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM167B | SNV | Missense_Mutation | novel | c.168N>G | p.His56Gln | p.H56Q | Q9NRX6 | protein_coding | tolerated(0.09) | benign(0.357) | TCGA-BH-A0DK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
TMEM167B | SNV | Missense_Mutation | novel | c.187N>C | p.Cys63Arg | p.C63R | Q9NRX6 | protein_coding | deleterious(0.01) | probably_damaging(0.946) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMEM167B | SNV | Missense_Mutation | novel | c.220N>C | p.Lys74Gln | p.K74Q | Q9NRX6 | protein_coding | tolerated(0.58) | benign(0.063) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMEM167B | SNV | Missense_Mutation | c.145G>T | p.Ala49Ser | p.A49S | Q9NRX6 | protein_coding | tolerated(0.25) | benign(0.022) | TCGA-CH-5766-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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