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Gene: TMEM141 |
Gene summary for TMEM141 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TMEM141 | Gene ID | 85014 |
Gene name | transmembrane protein 141 | |
Gene Alias | TMEM141 | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96I45 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85014 | TMEM141 | NCCBC5 | Human | Breast | DCIS | 6.83e-07 | 2.64e-02 | 0.2046 |
85014 | TMEM141 | NCCBC6 | Human | Breast | DCIS | 1.27e-02 | 3.65e-01 | 0.2095 |
85014 | TMEM141 | P1 | Human | Breast | IDC | 3.15e-11 | -2.25e-01 | 0.1527 |
85014 | TMEM141 | DCIS2 | Human | Breast | DCIS | 3.10e-54 | 1.44e-01 | 0.0085 |
85014 | TMEM141 | CA_HPV_1 | Human | Cervix | CC | 2.11e-10 | -2.87e-01 | 0.0264 |
85014 | TMEM141 | CA_HPV_3 | Human | Cervix | CC | 5.93e-04 | 1.63e-02 | 0.0414 |
85014 | TMEM141 | N_HPV_2 | Human | Cervix | N_HPV | 1.41e-02 | -7.11e-03 | -0.0131 |
85014 | TMEM141 | CCI_1 | Human | Cervix | CC | 3.46e-06 | -5.16e-01 | 0.528 |
85014 | TMEM141 | CCI_2 | Human | Cervix | CC | 1.42e-05 | -5.16e-01 | 0.5249 |
85014 | TMEM141 | CCI_3 | Human | Cervix | CC | 1.19e-08 | -5.16e-01 | 0.516 |
85014 | TMEM141 | CCII_1 | Human | Cervix | CC | 1.98e-12 | -5.16e-01 | 0.3249 |
85014 | TMEM141 | L1 | Human | Cervix | CC | 2.28e-03 | -3.43e-01 | 0.0802 |
85014 | TMEM141 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.30e-30 | 5.47e-01 | 0.0155 |
85014 | TMEM141 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.74e-47 | 1.16e+00 | -0.1808 |
85014 | TMEM141 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.49e-08 | 5.38e-01 | 0.0216 |
85014 | TMEM141 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.36e-50 | 1.41e+00 | -0.0811 |
85014 | TMEM141 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.29e-24 | 7.75e-01 | -0.1088 |
85014 | TMEM141 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.26e-46 | 7.85e-01 | -0.1954 |
85014 | TMEM141 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.54e-30 | 1.54e+00 | -0.2602 |
85014 | TMEM141 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.05e-27 | 1.32e+00 | -0.2196 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM141 | SNV | Missense_Mutation | novel | c.182N>G | p.Gln61Arg | p.Q61R | Q96I45 | protein_coding | tolerated(0.08) | benign(0.005) | TCGA-AA-3955-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | capecitabine | CR |
TMEM141 | SNV | Missense_Mutation | c.176N>A | p.Pro59His | p.P59H | Q96I45 | protein_coding | deleterious(0.03) | benign(0.292) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM141 | SNV | Missense_Mutation | c.93C>A | p.Phe31Leu | p.F31L | Q96I45 | protein_coding | tolerated(0.3) | probably_damaging(0.971) | TCGA-EY-A1GS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD | |
TMEM141 | SNV | Missense_Mutation | novel | c.83N>T | p.Ser28Leu | p.S28L | Q96I45 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
TMEM141 | SNV | Missense_Mutation | novel | c.160A>G | p.Arg54Gly | p.R54G | Q96I45 | protein_coding | deleterious(0) | possibly_damaging(0.501) | TCGA-VQ-A91S-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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