![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TMEM138 |
Gene summary for TMEM138 |
![]() |
Gene information | Species | Human | Gene symbol | TMEM138 | Gene ID | 51524 |
Gene name | transmembrane protein 138 | |
Gene Alias | HSPC196 | |
Cytomap | 11q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | J3QSZ6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51524 | TMEM138 | P20T-E | Human | Esophagus | ESCC | 5.33e-22 | 4.53e-01 | 0.1124 |
51524 | TMEM138 | P21T-E | Human | Esophagus | ESCC | 1.13e-25 | 5.28e-01 | 0.1617 |
51524 | TMEM138 | P22T-E | Human | Esophagus | ESCC | 2.68e-13 | 2.86e-01 | 0.1236 |
51524 | TMEM138 | P23T-E | Human | Esophagus | ESCC | 1.06e-28 | 6.13e-01 | 0.108 |
51524 | TMEM138 | P24T-E | Human | Esophagus | ESCC | 7.70e-13 | 2.72e-01 | 0.1287 |
51524 | TMEM138 | P26T-E | Human | Esophagus | ESCC | 6.87e-13 | 3.16e-01 | 0.1276 |
51524 | TMEM138 | P27T-E | Human | Esophagus | ESCC | 5.20e-19 | 3.94e-01 | 0.1055 |
51524 | TMEM138 | P28T-E | Human | Esophagus | ESCC | 3.77e-34 | 5.42e-01 | 0.1149 |
51524 | TMEM138 | P30T-E | Human | Esophagus | ESCC | 1.31e-20 | 5.50e-01 | 0.137 |
51524 | TMEM138 | P31T-E | Human | Esophagus | ESCC | 5.54e-17 | 3.44e-01 | 0.1251 |
51524 | TMEM138 | P32T-E | Human | Esophagus | ESCC | 1.45e-42 | 8.38e-01 | 0.1666 |
51524 | TMEM138 | P36T-E | Human | Esophagus | ESCC | 6.99e-20 | 5.14e-01 | 0.1187 |
51524 | TMEM138 | P37T-E | Human | Esophagus | ESCC | 7.72e-23 | 4.85e-01 | 0.1371 |
51524 | TMEM138 | P38T-E | Human | Esophagus | ESCC | 9.05e-06 | 1.30e-01 | 0.127 |
51524 | TMEM138 | P39T-E | Human | Esophagus | ESCC | 7.44e-09 | 1.24e-01 | 0.0894 |
51524 | TMEM138 | P40T-E | Human | Esophagus | ESCC | 9.25e-12 | 3.72e-01 | 0.109 |
51524 | TMEM138 | P42T-E | Human | Esophagus | ESCC | 1.15e-19 | 5.28e-01 | 0.1175 |
51524 | TMEM138 | P44T-E | Human | Esophagus | ESCC | 1.31e-11 | 3.28e-01 | 0.1096 |
51524 | TMEM138 | P47T-E | Human | Esophagus | ESCC | 2.38e-25 | 5.33e-01 | 0.1067 |
51524 | TMEM138 | P48T-E | Human | Esophagus | ESCC | 6.34e-14 | 2.58e-01 | 0.0959 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM138 | SNV | Missense_Mutation | c.482G>T | p.Arg161Leu | p.R161L | Q9NPI0 | protein_coding | deleterious(0.01) | benign(0.169) | TCGA-R2-A69V-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
TMEM138 | SNV | Missense_Mutation | rs202210746 | c.307C>T | p.Arg103Cys | p.R103C | Q9NPI0 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMEM138 | SNV | Missense_Mutation | rs781769843 | c.308N>A | p.Arg103His | p.R103H | Q9NPI0 | protein_coding | tolerated(0.22) | probably_damaging(0.982) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TMEM138 | SNV | Missense_Mutation | c.354G>A | p.Met118Ile | p.M118I | Q9NPI0 | protein_coding | tolerated(0.33) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM138 | SNV | Missense_Mutation | rs141029883 | c.415N>A | p.Val139Ile | p.V139I | Q9NPI0 | protein_coding | tolerated(0.33) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMEM138 | SNV | Missense_Mutation | novel | c.178N>C | p.Phe60Leu | p.F60L | Q9NPI0 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM138 | SNV | Missense_Mutation | c.275N>T | p.Ser92Ile | p.S92I | Q9NPI0 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM138 | SNV | Missense_Mutation | c.341N>C | p.Asp114Ala | p.D114A | Q9NPI0 | protein_coding | tolerated(0.12) | benign(0.029) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM138 | SNV | Missense_Mutation | c.223T>G | p.Phe75Val | p.F75V | Q9NPI0 | protein_coding | tolerated(0.62) | benign(0.001) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM138 | SNV | Missense_Mutation | c.58N>C | p.Tyr20His | p.Y20H | Q9NPI0 | protein_coding | tolerated(0.2) | possibly_damaging(0.885) | TCGA-G3-A3CK-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |