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Gene: TLDC1 |
Gene summary for TLDC1 |
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Gene information | Species | Human | Gene symbol | TLDC1 | Gene ID | 57707 |
Gene name | MTOR associated protein, eak-7 homolog | |
Gene Alias | EAK7 | |
Cytomap | 16q24.1 | |
Gene Type | protein-coding | GO ID | GO:0001101 | UniProtAcc | A8K5C2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57707 | TLDC1 | P30T-E | Human | Esophagus | ESCC | 3.84e-05 | 3.32e-01 | 0.137 |
57707 | TLDC1 | P31T-E | Human | Esophagus | ESCC | 3.45e-19 | 3.94e-01 | 0.1251 |
57707 | TLDC1 | P32T-E | Human | Esophagus | ESCC | 1.32e-05 | 2.24e-01 | 0.1666 |
57707 | TLDC1 | P36T-E | Human | Esophagus | ESCC | 2.55e-05 | 2.04e-01 | 0.1187 |
57707 | TLDC1 | P37T-E | Human | Esophagus | ESCC | 3.26e-23 | 5.06e-01 | 0.1371 |
57707 | TLDC1 | P39T-E | Human | Esophagus | ESCC | 9.97e-05 | 8.52e-02 | 0.0894 |
57707 | TLDC1 | P40T-E | Human | Esophagus | ESCC | 2.45e-04 | 1.59e-01 | 0.109 |
57707 | TLDC1 | P42T-E | Human | Esophagus | ESCC | 2.50e-04 | 2.11e-01 | 0.1175 |
57707 | TLDC1 | P44T-E | Human | Esophagus | ESCC | 1.32e-04 | 2.17e-01 | 0.1096 |
57707 | TLDC1 | P47T-E | Human | Esophagus | ESCC | 1.42e-21 | 3.24e-01 | 0.1067 |
57707 | TLDC1 | P48T-E | Human | Esophagus | ESCC | 2.20e-05 | 1.23e-01 | 0.0959 |
57707 | TLDC1 | P49T-E | Human | Esophagus | ESCC | 1.93e-08 | 7.44e-01 | 0.1768 |
57707 | TLDC1 | P52T-E | Human | Esophagus | ESCC | 1.57e-14 | 4.05e-01 | 0.1555 |
57707 | TLDC1 | P54T-E | Human | Esophagus | ESCC | 1.55e-09 | 2.94e-01 | 0.0975 |
57707 | TLDC1 | P57T-E | Human | Esophagus | ESCC | 1.30e-04 | 1.66e-01 | 0.0926 |
57707 | TLDC1 | P61T-E | Human | Esophagus | ESCC | 2.27e-09 | 2.10e-01 | 0.099 |
57707 | TLDC1 | P62T-E | Human | Esophagus | ESCC | 4.67e-43 | 7.88e-01 | 0.1302 |
57707 | TLDC1 | P65T-E | Human | Esophagus | ESCC | 3.77e-03 | 1.17e-01 | 0.0978 |
57707 | TLDC1 | P74T-E | Human | Esophagus | ESCC | 5.70e-12 | 3.16e-01 | 0.1479 |
57707 | TLDC1 | P75T-E | Human | Esophagus | ESCC | 1.61e-10 | 2.26e-01 | 0.1125 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TLDC1 | SNV | Missense_Mutation | rs777986149 | c.830N>C | p.His277Pro | p.H277P | Q6P9B6 | protein_coding | deleterious(0.03) | benign(0.425) | TCGA-A2-A0ST-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
TLDC1 | SNV | Missense_Mutation | rs148516272 | c.1157C>T | p.Thr386Met | p.T386M | Q6P9B6 | protein_coding | tolerated(0.06) | benign(0.348) | TCGA-AO-A1KR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
TLDC1 | insertion | In_Frame_Ins | novel | c.423_424insCATGGTTTAACTGTAATAGCGTACCGCACGGGTCACAGC | p.Leu141_Ser142insHisGlyLeuThrValIleAlaTyrArgThrGlyHisSer | p.L141_S142insHGLTVIAYRTGHS | Q6P9B6 | protein_coding | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
TLDC1 | SNV | Missense_Mutation | rs200383674 | c.1331N>A | p.Arg444His | p.R444H | Q6P9B6 | protein_coding | tolerated(0.27) | benign(0.015) | TCGA-EA-A3QD-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
TLDC1 | SNV | Missense_Mutation | c.614N>G | p.His205Arg | p.H205R | Q6P9B6 | protein_coding | tolerated(0.21) | benign(0.003) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TLDC1 | SNV | Missense_Mutation | c.34T>C | p.Phe12Leu | p.F12L | Q6P9B6 | protein_coding | tolerated(0.65) | benign(0) | TCGA-AA-3956-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TLDC1 | SNV | Missense_Mutation | c.688C>A | p.Leu230Met | p.L230M | Q6P9B6 | protein_coding | deleterious(0) | possibly_damaging(0.89) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
TLDC1 | SNV | Missense_Mutation | c.891N>T | p.Glu297Asp | p.E297D | Q6P9B6 | protein_coding | deleterious(0.01) | possibly_damaging(0.881) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
TLDC1 | SNV | Missense_Mutation | rs201799248 | c.889G>A | p.Glu297Lys | p.E297K | Q6P9B6 | protein_coding | tolerated(0.89) | benign(0.062) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
TLDC1 | SNV | Missense_Mutation | c.983N>T | p.Ser328Phe | p.S328F | Q6P9B6 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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