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Gene: TAGLN |
Gene summary for TAGLN |
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Gene information | Species | Human | Gene symbol | TAGLN | Gene ID | 6876 |
Gene name | transgelin | |
Gene Alias | SM22 | |
Cytomap | 11q23.3 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q01995 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6876 | TAGLN | DCIS2 | Human | Breast | DCIS | 2.38e-10 | 3.87e-01 | 0.0085 |
6876 | TAGLN | AEH-subject1 | Human | Endometrium | AEH | 1.95e-25 | -7.44e-01 | -0.3059 |
6876 | TAGLN | AEH-subject2 | Human | Endometrium | AEH | 2.24e-10 | -5.40e-01 | -0.2525 |
6876 | TAGLN | AEH-subject3 | Human | Endometrium | AEH | 3.46e-15 | -6.30e-01 | -0.2576 |
6876 | TAGLN | AEH-subject4 | Human | Endometrium | AEH | 3.98e-11 | -6.08e-01 | -0.2657 |
6876 | TAGLN | AEH-subject5 | Human | Endometrium | AEH | 4.25e-21 | -6.75e-01 | -0.2953 |
6876 | TAGLN | EEC-subject1 | Human | Endometrium | EEC | 1.69e-32 | -8.07e-01 | -0.2682 |
6876 | TAGLN | EEC-subject2 | Human | Endometrium | EEC | 2.12e-30 | -7.69e-01 | -0.2607 |
6876 | TAGLN | EEC-subject3 | Human | Endometrium | EEC | 3.49e-10 | -3.63e-01 | -0.2525 |
6876 | TAGLN | EEC-subject4 | Human | Endometrium | EEC | 5.16e-13 | -5.56e-01 | -0.2571 |
6876 | TAGLN | EEC-subject5 | Human | Endometrium | EEC | 1.57e-33 | -7.99e-01 | -0.249 |
6876 | TAGLN | GSM5276934 | Human | Endometrium | EEC | 6.60e-17 | -6.26e-01 | -0.0913 |
6876 | TAGLN | GSM5276935 | Human | Endometrium | EEC | 7.46e-36 | -8.29e-01 | -0.123 |
6876 | TAGLN | GSM5276937 | Human | Endometrium | EEC | 2.74e-06 | -4.93e-01 | -0.0897 |
6876 | TAGLN | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 4.94e-26 | -7.81e-01 | -0.1869 |
6876 | TAGLN | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 4.28e-31 | -8.65e-01 | -0.1875 |
6876 | TAGLN | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 6.40e-27 | -7.92e-01 | -0.1883 |
6876 | TAGLN | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 3.35e-33 | -7.50e-01 | -0.1934 |
6876 | TAGLN | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 6.21e-31 | -7.33e-01 | -0.1917 |
6876 | TAGLN | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.35e-35 | -7.93e-01 | -0.1916 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00075172 | Breast | IDC | muscle organ development | 38/1434 | 327/18723 | 6.63e-03 | 4.62e-02 | 38 |
GO:00075171 | Breast | DCIS | muscle organ development | 37/1390 | 327/18723 | 6.86e-03 | 4.75e-02 | 37 |
GO:00075174 | Endometrium | AEH | muscle organ development | 60/2100 | 327/18723 | 8.19e-05 | 1.22e-03 | 60 |
GO:000751712 | Endometrium | EEC | muscle organ development | 59/2168 | 327/18723 | 3.49e-04 | 3.85e-03 | 59 |
GO:000751714 | Oral cavity | NEOLP | muscle organ development | 56/2005 | 327/18723 | 2.65e-04 | 2.70e-03 | 56 |
GO:00075175 | Prostate | BPH | muscle organ development | 71/3107 | 327/18723 | 9.00e-03 | 3.84e-02 | 71 |
GO:000751713 | Prostate | Tumor | muscle organ development | 74/3246 | 327/18723 | 8.03e-03 | 3.54e-02 | 74 |
GO:000751716 | Thyroid | ATC | muscle organ development | 139/6293 | 327/18723 | 4.45e-04 | 2.64e-03 | 139 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TAGLN | SNV | Missense_Mutation | c.596N>C | p.Ile199Thr | p.I199T | Q01995 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TAGLN | SNV | Missense_Mutation | rs138736412 | c.467N>T | p.Ala156Val | p.A156V | Q01995 | protein_coding | deleterious(0.01) | benign(0.371) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TAGLN | SNV | Missense_Mutation | rs774227686 | c.37N>A | p.Glu13Lys | p.E13K | Q01995 | protein_coding | deleterious(0) | possibly_damaging(0.509) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TAGLN | SNV | Missense_Mutation | rs774227686 | c.37G>A | p.Glu13Lys | p.E13K | Q01995 | protein_coding | deleterious(0) | possibly_damaging(0.509) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TAGLN | SNV | Missense_Mutation | rs746670728 | c.70N>A | p.Glu24Lys | p.E24K | Q01995 | protein_coding | tolerated(0.29) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TAGLN | SNV | Missense_Mutation | rs780383343 | c.227C>T | p.Pro76Leu | p.P76L | Q01995 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TAGLN | SNV | Missense_Mutation | rs772350872 | c.580N>A | p.Gly194Arg | p.G194R | Q01995 | protein_coding | deleterious(0.02) | possibly_damaging(0.449) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TAGLN | SNV | Missense_Mutation | rs747524780 | c.584N>A | p.Arg195Gln | p.R195Q | Q01995 | protein_coding | tolerated(0.41) | benign(0.037) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TAGLN | SNV | Missense_Mutation | c.203N>T | p.Ser68Ile | p.S68I | Q01995 | protein_coding | deleterious(0.04) | probably_damaging(0.937) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TAGLN | SNV | Missense_Mutation | c.322N>G | p.Lys108Glu | p.K108E | Q01995 | protein_coding | deleterious(0.04) | benign(0.027) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6876 | TAGLN | NA | 5-AZACYTIDINE | AZACITIDINE | 14662021 | |
6876 | TAGLN | NA | TGFBETA1 | 16876108 |
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