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Gene: TAF9B |
Gene summary for TAF9B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TAF9B | Gene ID | 51616 |
| Gene name | TATA-box binding protein associated factor 9b | |
| Gene Alias | DN-7 | |
| Cytomap | Xq21.1 | |
| Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9HBM6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 51616 | TAF9B | P30T-E | Human | Esophagus | ESCC | 8.45e-05 | 2.01e-01 | 0.137 |
| 51616 | TAF9B | P31T-E | Human | Esophagus | ESCC | 1.36e-08 | 1.54e-01 | 0.1251 |
| 51616 | TAF9B | P32T-E | Human | Esophagus | ESCC | 7.13e-19 | 4.07e-01 | 0.1666 |
| 51616 | TAF9B | P36T-E | Human | Esophagus | ESCC | 8.94e-07 | 2.79e-01 | 0.1187 |
| 51616 | TAF9B | P37T-E | Human | Esophagus | ESCC | 5.48e-09 | 6.70e-02 | 0.1371 |
| 51616 | TAF9B | P39T-E | Human | Esophagus | ESCC | 4.16e-06 | 8.51e-02 | 0.0894 |
| 51616 | TAF9B | P40T-E | Human | Esophagus | ESCC | 3.96e-08 | 1.46e-01 | 0.109 |
| 51616 | TAF9B | P42T-E | Human | Esophagus | ESCC | 2.33e-14 | 3.34e-01 | 0.1175 |
| 51616 | TAF9B | P44T-E | Human | Esophagus | ESCC | 1.84e-05 | 1.49e-01 | 0.1096 |
| 51616 | TAF9B | P47T-E | Human | Esophagus | ESCC | 2.71e-12 | 1.46e-01 | 0.1067 |
| 51616 | TAF9B | P48T-E | Human | Esophagus | ESCC | 1.36e-08 | 1.06e-01 | 0.0959 |
| 51616 | TAF9B | P49T-E | Human | Esophagus | ESCC | 1.40e-05 | 8.94e-01 | 0.1768 |
| 51616 | TAF9B | P52T-E | Human | Esophagus | ESCC | 4.84e-05 | 1.13e-01 | 0.1555 |
| 51616 | TAF9B | P54T-E | Human | Esophagus | ESCC | 5.14e-03 | 6.99e-02 | 0.0975 |
| 51616 | TAF9B | P56T-E | Human | Esophagus | ESCC | 6.59e-03 | 3.88e-01 | 0.1613 |
| 51616 | TAF9B | P57T-E | Human | Esophagus | ESCC | 8.42e-03 | 1.37e-01 | 0.0926 |
| 51616 | TAF9B | P61T-E | Human | Esophagus | ESCC | 5.31e-09 | 2.75e-01 | 0.099 |
| 51616 | TAF9B | P62T-E | Human | Esophagus | ESCC | 3.07e-28 | 4.15e-01 | 0.1302 |
| 51616 | TAF9B | P65T-E | Human | Esophagus | ESCC | 4.61e-09 | 2.02e-01 | 0.0978 |
| 51616 | TAF9B | P74T-E | Human | Esophagus | ESCC | 9.92e-09 | 1.90e-01 | 0.1479 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0097193111 | Esophagus | ESCC | intrinsic apoptotic signaling pathway | 222/8552 | 288/18723 | 5.87e-28 | 2.02e-25 | 222 |
| GO:0031647111 | Esophagus | ESCC | regulation of protein stability | 223/8552 | 298/18723 | 5.76e-25 | 1.52e-22 | 223 |
| GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
| GO:2001242111 | Esophagus | ESCC | regulation of intrinsic apoptotic signaling pathway | 128/8552 | 164/18723 | 1.75e-17 | 1.50e-15 | 128 |
| GO:2001234111 | Esophagus | ESCC | negative regulation of apoptotic signaling pathway | 161/8552 | 224/18723 | 1.24e-15 | 8.09e-14 | 161 |
| GO:0050821111 | Esophagus | ESCC | protein stabilization | 140/8552 | 191/18723 | 6.50e-15 | 3.61e-13 | 140 |
| GO:0072331111 | Esophagus | ESCC | signal transduction by p53 class mediator | 121/8552 | 163/18723 | 9.61e-14 | 4.69e-12 | 121 |
| GO:2001243111 | Esophagus | ESCC | negative regulation of intrinsic apoptotic signaling pathway | 78/8552 | 98/18723 | 5.50e-12 | 2.10e-10 | 78 |
| GO:0008630110 | Esophagus | ESCC | intrinsic apoptotic signaling pathway in response to DNA damage | 78/8552 | 99/18723 | 1.43e-11 | 5.08e-10 | 78 |
| GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
| GO:2001020110 | Esophagus | ESCC | regulation of response to DNA damage stimulus | 145/8552 | 219/18723 | 5.97e-10 | 1.50e-08 | 145 |
| GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
| GO:1901796111 | Esophagus | ESCC | regulation of signal transduction by p53 class mediator | 70/8552 | 93/18723 | 5.69e-09 | 1.18e-07 | 70 |
| GO:0042771110 | Esophagus | ESCC | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 38/8552 | 43/18723 | 5.75e-09 | 1.18e-07 | 38 |
| GO:0072332111 | Esophagus | ESCC | intrinsic apoptotic signaling pathway by p53 class mediator | 59/8552 | 76/18723 | 1.22e-08 | 2.42e-07 | 59 |
| GO:000635211 | Esophagus | ESCC | DNA-templated transcription, initiation | 86/8552 | 130/18723 | 1.88e-06 | 2.19e-05 | 86 |
| GO:19022298 | Esophagus | ESCC | regulation of intrinsic apoptotic signaling pathway in response to DNA damage | 28/8552 | 36/18723 | 8.62e-05 | 6.22e-04 | 28 |
| GO:003030710 | Esophagus | ESCC | positive regulation of cell growth | 100/8552 | 166/18723 | 1.07e-04 | 7.55e-04 | 100 |
| GO:200102112 | Esophagus | ESCC | negative regulation of response to DNA damage stimulus | 54/8552 | 81/18723 | 1.09e-04 | 7.64e-04 | 54 |
| GO:19022304 | Esophagus | ESCC | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | 23/8552 | 29/18723 | 2.25e-04 | 1.40e-03 | 23 |
| Page: 1 2 3 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa030222 | Esophagus | ESCC | Basal transcription factors | 35/4205 | 45/8465 | 1.01e-04 | 4.06e-04 | 2.08e-04 | 35 |
| hsa0302211 | Esophagus | ESCC | Basal transcription factors | 35/4205 | 45/8465 | 1.01e-04 | 4.06e-04 | 2.08e-04 | 35 |
| hsa03022 | Oral cavity | OSCC | Basal transcription factors | 28/3704 | 45/8465 | 9.53e-03 | 2.11e-02 | 1.08e-02 | 28 |
| hsa030221 | Oral cavity | OSCC | Basal transcription factors | 28/3704 | 45/8465 | 9.53e-03 | 2.11e-02 | 1.08e-02 | 28 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TAF9B | SNV | Missense_Mutation | c.644N>C | p.Gly215Ala | p.G215A | Q9HBM6 | protein_coding | tolerated(0.15) | probably_damaging(0.992) | TCGA-B6-A0RS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| TAF9B | SNV | Missense_Mutation | c.595N>T | p.Pro199Ser | p.P199S | Q9HBM6 | protein_coding | tolerated(0.32) | probably_damaging(0.968) | TCGA-FU-A23K-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
| TAF9B | SNV | Missense_Mutation | novel | c.707N>C | p.Asn236Thr | p.N236T | Q9HBM6 | protein_coding | tolerated(0.15) | benign(0) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| TAF9B | SNV | Missense_Mutation | c.176N>C | p.Ser59Thr | p.S59T | Q9HBM6 | protein_coding | tolerated(0.34) | benign(0.007) | TCGA-AA-3693-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| TAF9B | SNV | Missense_Mutation | c.52N>T | p.Val18Leu | p.V18L | Q9HBM6 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-AA-3693-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| TAF9B | SNV | Missense_Mutation | c.694N>A | p.Ala232Thr | p.A232T | Q9HBM6 | protein_coding | tolerated(0.4) | benign(0.011) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TAF9B | SNV | Missense_Mutation | novel | c.148N>C | p.Ile50Leu | p.I50L | Q9HBM6 | protein_coding | deleterious(0.01) | possibly_damaging(0.768) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TAF9B | SNV | Missense_Mutation | c.199N>C | p.Asp67His | p.D67H | Q9HBM6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-A01J-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| TAF9B | SNV | Missense_Mutation | c.619N>A | p.Val207Ile | p.V207I | Q9HBM6 | protein_coding | deleterious(0.05) | possibly_damaging(0.785) | TCGA-A5-A0GN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TAF9B | SNV | Missense_Mutation | rs376084606 | c.680N>T | p.Ser227Leu | p.S227L | Q9HBM6 | protein_coding | tolerated(0.11) | possibly_damaging(0.885) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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