Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SULT1A3

Gene summary for SULT1A3

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SULT1A3

Gene ID

6818

Gene namesulfotransferase family 1A member 3
Gene AliasHAST
Cytomap16p11.2
Gene Typeprotein-coding
GO ID

GO:0000165

UniProtAcc

P0DMM9


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
6818SULT1A3HTA11_7696_3000711011HumanColorectumAD8.62e-041.23e-010.0674
6818SULT1A3HTA11_6818_2000001011HumanColorectumAD6.25e-062.89e-010.0112
6818SULT1A3HTA11_7469_2000001011HumanColorectumAD2.51e-085.28e-01-0.0124
6818SULT1A3HTA11_6818_2000001021HumanColorectumAD3.40e-072.40e-010.0588
6818SULT1A3HTA11_99999970781_79442HumanColorectumMSS4.38e-061.69e-010.294
6818SULT1A3HTA11_99999971662_82457HumanColorectumMSS2.05e-061.60e-010.3859
6818SULT1A3HTA11_99999974143_84620HumanColorectumMSS9.04e-051.39e-010.3005
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0009150ColorectumADpurine ribonucleotide metabolic process142/3918368/187234.29e-151.17e-12142
GO:0006163ColorectumADpurine nucleotide metabolic process149/3918396/187231.08e-142.80e-12149
GO:0072521ColorectumADpurine-containing compound metabolic process153/3918416/187234.34e-141.01e-11153
GO:0009259ColorectumADribonucleotide metabolic process144/3918385/187235.25e-141.13e-11144
GO:0019693ColorectumADribose phosphate metabolic process145/3918396/187233.01e-135.71e-11145
GO:0009117ColorectumADnucleotide metabolic process168/3918489/187232.20e-123.36e-10168
GO:0006753ColorectumADnucleoside phosphate metabolic process169/3918497/187234.99e-126.98e-10169
GO:0019439ColorectumADaromatic compound catabolic process146/3918467/187237.48e-083.84e-06146
GO:1901361ColorectumADorganic cyclic compound catabolic process153/3918495/187238.23e-084.18e-06153
GO:0044282ColorectumADsmall molecule catabolic process118/3918376/187231.05e-063.55e-05118
GO:0070997ColorectumADneuron death114/3918361/187231.13e-063.72e-05114
GO:1901214ColorectumADregulation of neuron death99/3918319/187231.26e-052.76e-0499
GO:0006066ColorectumADalcohol metabolic process106/3918353/187233.02e-055.57e-04106
GO:0006790ColorectumADsulfur compound metabolic process101/3918339/187236.46e-051.07e-03101
GO:1901215ColorectumADnegative regulation of neuron death67/3918208/187238.81e-051.35e-0367
GO:0009410ColorectumADresponse to xenobiotic stimulus128/3918462/187232.69e-043.31e-03128
GO:0034310ColorectumADprimary alcohol catabolic process9/391815/187231.11e-031.01e-029
GO:0033865ColorectumADnucleoside bisphosphate metabolic process42/3918128/187231.12e-031.02e-0242
GO:0033875ColorectumADribonucleoside bisphosphate metabolic process42/3918128/187231.12e-031.02e-0242
GO:0034032ColorectumADpurine nucleoside bisphosphate metabolic process42/3918128/187231.12e-031.02e-0242
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
6818SULT1A3DRUGGABLE GENOME, ENZYMEacetaminophenACETAMINOPHEN23462933,26049587
6818SULT1A3DRUGGABLE GENOME, ENZYMEtramadolTRAMADOL
6818SULT1A3DRUGGABLE GENOME, ENZYMEo-desmethyl-tramadol
6818SULT1A3DRUGGABLE GENOME, ENZYMEtapentadolTAPENTADOL
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