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Gene: STXBP6 |
Gene summary for STXBP6 |
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Gene information | Species | Human | Gene symbol | STXBP6 | Gene ID | 29091 |
Gene name | syntaxin binding protein 6 | |
Gene Alias | HSPC156 | |
Cytomap | 14q12 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8NFX7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29091 | STXBP6 | A002-C-016 | Human | Colorectum | FAP | 1.63e-15 | -2.90e-01 | 0.0521 |
29091 | STXBP6 | A015-C-002 | Human | Colorectum | FAP | 5.59e-09 | -4.19e-01 | -0.0763 |
29091 | STXBP6 | A001-C-203 | Human | Colorectum | FAP | 2.47e-08 | -1.20e-01 | -0.0481 |
29091 | STXBP6 | A002-C-116 | Human | Colorectum | FAP | 1.12e-32 | -5.28e-01 | -0.0452 |
29091 | STXBP6 | A014-C-008 | Human | Colorectum | FAP | 1.56e-10 | -4.29e-01 | -0.191 |
29091 | STXBP6 | A018-E-020 | Human | Colorectum | FAP | 2.87e-24 | -6.87e-01 | -0.2034 |
29091 | STXBP6 | F034 | Human | Colorectum | FAP | 8.00e-18 | -3.80e-01 | -0.0665 |
29091 | STXBP6 | F072B | Human | Colorectum | FAP | 2.58e-02 | -1.27e-01 | 0.257 |
29091 | STXBP6 | CRC-3-11773 | Human | Colorectum | CRC | 9.73e-12 | -3.97e-01 | 0.2564 |
29091 | STXBP6 | AEH-subject1 | Human | Endometrium | AEH | 2.12e-23 | 7.28e-01 | -0.3059 |
29091 | STXBP6 | AEH-subject2 | Human | Endometrium | AEH | 1.77e-08 | 4.67e-01 | -0.2525 |
29091 | STXBP6 | AEH-subject5 | Human | Endometrium | AEH | 2.51e-15 | 6.35e-01 | -0.2953 |
29091 | STXBP6 | EEC-subject1 | Human | Endometrium | EEC | 6.70e-03 | 3.87e-01 | -0.2682 |
29091 | STXBP6 | EEC-subject2 | Human | Endometrium | EEC | 1.75e-24 | 6.82e-01 | -0.2607 |
29091 | STXBP6 | EEC-subject3 | Human | Endometrium | EEC | 1.66e-13 | -1.84e-01 | -0.2525 |
29091 | STXBP6 | EEC-subject4 | Human | Endometrium | EEC | 2.77e-10 | 5.15e-01 | -0.2571 |
29091 | STXBP6 | EEC-subject5 | Human | Endometrium | EEC | 1.53e-04 | 3.85e-01 | -0.249 |
29091 | STXBP6 | GSM5276934 | Human | Endometrium | EEC | 1.20e-12 | -2.88e-01 | -0.0913 |
29091 | STXBP6 | GSM5276935 | Human | Endometrium | EEC | 8.35e-48 | 9.31e-01 | -0.123 |
29091 | STXBP6 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.54e-18 | 4.65e-01 | -0.1869 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0098876 | Colorectum | AD | vesicle-mediated transport to the plasma membrane | 57/3918 | 136/18723 | 2.30e-08 | 1.27e-06 | 57 |
GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
GO:0006892 | Colorectum | AD | post-Golgi vesicle-mediated transport | 45/3918 | 104/18723 | 2.22e-07 | 9.26e-06 | 45 |
GO:0006893 | Colorectum | AD | Golgi to plasma membrane transport | 27/3918 | 60/18723 | 2.41e-05 | 4.66e-04 | 27 |
GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
GO:0017157 | Colorectum | AD | regulation of exocytosis | 59/3918 | 202/18723 | 3.20e-03 | 2.36e-02 | 59 |
GO:0048284 | Colorectum | AD | organelle fusion | 42/3918 | 141/18723 | 8.04e-03 | 4.73e-02 | 42 |
GO:00481932 | Colorectum | MSS | Golgi vesicle transport | 101/3467 | 296/18723 | 9.09e-11 | 9.77e-09 | 101 |
GO:00432542 | Colorectum | MSS | regulation of protein-containing complex assembly | 130/3467 | 428/18723 | 1.38e-09 | 1.03e-07 | 130 |
GO:00988762 | Colorectum | MSS | vesicle-mediated transport to the plasma membrane | 54/3467 | 136/18723 | 6.20e-09 | 3.95e-07 | 54 |
GO:00160502 | Colorectum | MSS | vesicle organization | 93/3467 | 300/18723 | 1.04e-07 | 4.97e-06 | 93 |
GO:00068922 | Colorectum | MSS | post-Golgi vesicle-mediated transport | 40/3467 | 104/18723 | 1.45e-06 | 4.82e-05 | 40 |
GO:00068931 | Colorectum | MSS | Golgi to plasma membrane transport | 26/3467 | 60/18723 | 8.01e-06 | 2.03e-04 | 26 |
GO:00510511 | Colorectum | MSS | negative regulation of transport | 110/3467 | 470/18723 | 4.20e-03 | 3.04e-02 | 110 |
GO:00482841 | Colorectum | MSS | organelle fusion | 39/3467 | 141/18723 | 4.91e-03 | 3.42e-02 | 39 |
GO:00481934 | Colorectum | FAP | Golgi vesicle transport | 77/2622 | 296/18723 | 2.86e-08 | 2.62e-06 | 77 |
GO:00432544 | Colorectum | FAP | regulation of protein-containing complex assembly | 101/2622 | 428/18723 | 5.18e-08 | 4.07e-06 | 101 |
GO:00068923 | Colorectum | FAP | post-Golgi vesicle-mediated transport | 36/2622 | 104/18723 | 9.23e-08 | 6.22e-06 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STXBP6 | SNV | Missense_Mutation | c.501N>C | p.Gln167His | p.Q167H | Q8NFX7 | protein_coding | tolerated(0.05) | benign(0.044) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
STXBP6 | SNV | Missense_Mutation | novel | c.49N>A | p.Glu17Lys | p.E17K | Q8NFX7 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
STXBP6 | SNV | Missense_Mutation | rs767031935 | c.48N>A | p.Asp16Glu | p.D16E | Q8NFX7 | protein_coding | tolerated(0.13) | probably_damaging(0.981) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
STXBP6 | SNV | Missense_Mutation | novel | c.618N>A | p.Met206Ile | p.M206I | Q8NFX7 | protein_coding | tolerated(0.25) | benign(0) | TCGA-D8-A4Z1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
STXBP6 | SNV | Missense_Mutation | c.233N>T | p.Ser78Leu | p.S78L | Q8NFX7 | protein_coding | deleterious(0.03) | benign(0.131) | TCGA-C5-A1MN-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
STXBP6 | SNV | Missense_Mutation | rs769103083 | c.526N>T | p.Arg176Cys | p.R176C | Q8NFX7 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
STXBP6 | SNV | Missense_Mutation | novel | c.226C>T | p.Arg76Trp | p.R76W | Q8NFX7 | protein_coding | deleterious(0) | possibly_damaging(0.646) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
STXBP6 | SNV | Missense_Mutation | c.274G>A | p.Asp92Asn | p.D92N | Q8NFX7 | protein_coding | tolerated(0.26) | benign(0) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
STXBP6 | SNV | Missense_Mutation | c.34N>A | p.Phe12Ile | p.F12I | Q8NFX7 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-AP-A0LD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
STXBP6 | SNV | Missense_Mutation | novel | c.406N>A | p.Asp136Asn | p.D136N | Q8NFX7 | protein_coding | tolerated(0.27) | benign(0.01) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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