|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: STXBP1 |
Gene summary for STXBP1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | STXBP1 | Gene ID | 6812 |
| Gene name | syntaxin binding protein 1 | |
| Gene Alias | DEE4 | |
| Cytomap | 9q34.11 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P61764 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 6812 | STXBP1 | LZE4T | Human | Esophagus | ESCC | 1.10e-02 | 5.60e-02 | 0.0811 |
| 6812 | STXBP1 | LZE24T | Human | Esophagus | ESCC | 2.96e-04 | 4.16e-02 | 0.0596 |
| 6812 | STXBP1 | P2T-E | Human | Esophagus | ESCC | 1.04e-13 | 2.69e-01 | 0.1177 |
| 6812 | STXBP1 | P4T-E | Human | Esophagus | ESCC | 3.21e-17 | 3.45e-01 | 0.1323 |
| 6812 | STXBP1 | P5T-E | Human | Esophagus | ESCC | 2.53e-08 | 4.55e-02 | 0.1327 |
| 6812 | STXBP1 | P8T-E | Human | Esophagus | ESCC | 4.78e-08 | 1.61e-02 | 0.0889 |
| 6812 | STXBP1 | P9T-E | Human | Esophagus | ESCC | 4.93e-03 | 1.04e-01 | 0.1131 |
| 6812 | STXBP1 | P10T-E | Human | Esophagus | ESCC | 3.49e-20 | 2.50e-01 | 0.116 |
| 6812 | STXBP1 | P11T-E | Human | Esophagus | ESCC | 1.65e-08 | 3.88e-01 | 0.1426 |
| 6812 | STXBP1 | P15T-E | Human | Esophagus | ESCC | 3.50e-09 | 1.71e-01 | 0.1149 |
| 6812 | STXBP1 | P16T-E | Human | Esophagus | ESCC | 1.09e-11 | 1.19e-01 | 0.1153 |
| 6812 | STXBP1 | P17T-E | Human | Esophagus | ESCC | 3.44e-04 | 2.50e-01 | 0.1278 |
| 6812 | STXBP1 | P19T-E | Human | Esophagus | ESCC | 6.65e-05 | 2.49e-01 | 0.1662 |
| 6812 | STXBP1 | P21T-E | Human | Esophagus | ESCC | 2.95e-25 | 6.03e-01 | 0.1617 |
| 6812 | STXBP1 | P22T-E | Human | Esophagus | ESCC | 3.96e-19 | 3.00e-01 | 0.1236 |
| 6812 | STXBP1 | P23T-E | Human | Esophagus | ESCC | 6.04e-04 | 3.87e-02 | 0.108 |
| 6812 | STXBP1 | P24T-E | Human | Esophagus | ESCC | 2.41e-11 | 2.50e-01 | 0.1287 |
| 6812 | STXBP1 | P26T-E | Human | Esophagus | ESCC | 2.46e-15 | 2.09e-01 | 0.1276 |
| 6812 | STXBP1 | P27T-E | Human | Esophagus | ESCC | 5.05e-10 | 9.59e-02 | 0.1055 |
| 6812 | STXBP1 | P28T-E | Human | Esophagus | ESCC | 3.22e-11 | 1.44e-01 | 0.1149 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
| GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
| GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
| GO:0031647 | Colorectum | AD | regulation of protein stability | 108/3918 | 298/18723 | 6.33e-10 | 5.08e-08 | 108 |
| GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
| GO:0050821 | Colorectum | AD | protein stabilization | 73/3918 | 191/18723 | 3.02e-08 | 1.64e-06 | 73 |
| GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
| GO:0034109 | Colorectum | AD | homotypic cell-cell adhesion | 40/3918 | 90/18723 | 4.37e-07 | 1.67e-05 | 40 |
| GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
| GO:0042060 | Colorectum | AD | wound healing | 128/3918 | 422/18723 | 2.73e-06 | 7.89e-05 | 128 |
| GO:0031333 | Colorectum | AD | negative regulation of protein-containing complex assembly | 52/3918 | 141/18723 | 9.27e-06 | 2.18e-04 | 52 |
| GO:1901214 | Colorectum | AD | regulation of neuron death | 99/3918 | 319/18723 | 1.26e-05 | 2.76e-04 | 99 |
| GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
| GO:0051402 | Colorectum | AD | neuron apoptotic process | 77/3918 | 246/18723 | 8.07e-05 | 1.28e-03 | 77 |
| GO:0061564 | Colorectum | AD | axon development | 132/3918 | 467/18723 | 8.40e-05 | 1.31e-03 | 132 |
| GO:1901215 | Colorectum | AD | negative regulation of neuron death | 67/3918 | 208/18723 | 8.81e-05 | 1.35e-03 | 67 |
| GO:0045921 | Colorectum | AD | positive regulation of exocytosis | 33/3918 | 86/18723 | 1.58e-04 | 2.20e-03 | 33 |
| GO:0050878 | Colorectum | AD | regulation of body fluid levels | 108/3918 | 379/18723 | 2.54e-04 | 3.20e-03 | 108 |
| GO:0051047 | Colorectum | AD | positive regulation of secretion | 90/3918 | 310/18723 | 4.11e-04 | 4.66e-03 | 90 |
| GO:0070527 | Colorectum | AD | platelet aggregation | 26/3918 | 67/18723 | 6.20e-04 | 6.48e-03 | 26 |
| Page: 1 2 3 4 5 6 7 8 9 10 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| STXBP1 | SNV | Missense_Mutation | novel | c.605N>A | p.Ala202Asp | p.A202D | P61764 | protein_coding | deleterious(0) | possibly_damaging(0.816) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| STXBP1 | SNV | Missense_Mutation | c.406G>A | p.Ala136Thr | p.A136T | P61764 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
| STXBP1 | SNV | Missense_Mutation | c.821N>T | p.Ala274Val | p.A274V | P61764 | protein_coding | tolerated(0.23) | benign(0.005) | TCGA-C8-A131-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
| STXBP1 | insertion | Frame_Shift_Ins | novel | c.1327_1328insTCATATT | p.Met443IlefsTer51 | p.M443Ifs*51 | P61764 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| STXBP1 | insertion | Nonsense_Mutation | novel | c.1329_1330insTCCGTGCCAGGTTTTTAATTGGTTTCCATTTTT | p.Met443_Ala444insSerValProGlyPheTerLeuValSerIlePhe | p.M443_A444insSVPGF*LVSIF | P61764 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| STXBP1 | insertion | In_Frame_Ins | novel | c.1646_1647insCCTTCTCAT | p.Glu549delinsAspLeuLeuMet | p.E549delinsDLLM | P61764 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
| STXBP1 | insertion | In_Frame_Ins | novel | c.1647_1648insGCAGCAGAGGTAAAACGTTTTTTGCCAAAT | p.Glu549_Met550insAlaAlaGluValLysArgPheLeuProAsn | p.E549_M550insAAEVKRFLPN | P61764 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
| STXBP1 | SNV | Missense_Mutation | novel | c.278N>G | p.Asp93Gly | p.D93G | P61764 | protein_coding | tolerated(0.65) | benign(0.009) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| STXBP1 | SNV | Missense_Mutation | novel | c.495N>T | p.Lys165Asn | p.K165N | P61764 | protein_coding | deleterious(0.04) | possibly_damaging(0.572) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| STXBP1 | SNV | Missense_Mutation | rs794727970 | c.704N>A | p.Arg235Gln | p.R235Q | P61764 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |