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Gene: STX12 |
Gene summary for STX12 |
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Gene information | Species | Human | Gene symbol | STX12 | Gene ID | 23673 |
Gene name | syntaxin 12 | |
Gene Alias | STX13 | |
Cytomap | 1p35.3 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q86Y82 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23673 | STX12 | P22T-E | Human | Esophagus | ESCC | 4.83e-12 | 1.26e-01 | 0.1236 |
23673 | STX12 | P23T-E | Human | Esophagus | ESCC | 4.80e-29 | 7.88e-01 | 0.108 |
23673 | STX12 | P24T-E | Human | Esophagus | ESCC | 3.30e-14 | 2.88e-01 | 0.1287 |
23673 | STX12 | P26T-E | Human | Esophagus | ESCC | 5.89e-22 | 4.06e-01 | 0.1276 |
23673 | STX12 | P27T-E | Human | Esophagus | ESCC | 3.04e-23 | 4.43e-01 | 0.1055 |
23673 | STX12 | P28T-E | Human | Esophagus | ESCC | 2.58e-23 | 6.27e-01 | 0.1149 |
23673 | STX12 | P30T-E | Human | Esophagus | ESCC | 8.99e-17 | 5.75e-01 | 0.137 |
23673 | STX12 | P31T-E | Human | Esophagus | ESCC | 8.58e-22 | 4.00e-01 | 0.1251 |
23673 | STX12 | P32T-E | Human | Esophagus | ESCC | 3.27e-24 | 5.21e-01 | 0.1666 |
23673 | STX12 | P36T-E | Human | Esophagus | ESCC | 9.05e-10 | 3.66e-01 | 0.1187 |
23673 | STX12 | P37T-E | Human | Esophagus | ESCC | 2.90e-19 | 3.24e-01 | 0.1371 |
23673 | STX12 | P38T-E | Human | Esophagus | ESCC | 2.40e-05 | 1.84e-01 | 0.127 |
23673 | STX12 | P39T-E | Human | Esophagus | ESCC | 2.06e-43 | 8.40e-01 | 0.0894 |
23673 | STX12 | P40T-E | Human | Esophagus | ESCC | 1.54e-13 | 5.82e-01 | 0.109 |
23673 | STX12 | P42T-E | Human | Esophagus | ESCC | 5.61e-24 | 5.81e-01 | 0.1175 |
23673 | STX12 | P44T-E | Human | Esophagus | ESCC | 1.82e-12 | 3.67e-01 | 0.1096 |
23673 | STX12 | P47T-E | Human | Esophagus | ESCC | 3.34e-15 | 3.97e-01 | 0.1067 |
23673 | STX12 | P48T-E | Human | Esophagus | ESCC | 9.90e-11 | 2.90e-01 | 0.0959 |
23673 | STX12 | P49T-E | Human | Esophagus | ESCC | 1.21e-06 | 7.99e-01 | 0.1768 |
23673 | STX12 | P52T-E | Human | Esophagus | ESCC | 1.37e-15 | 3.97e-01 | 0.1555 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0031647111 | Esophagus | ESCC | regulation of protein stability | 223/8552 | 298/18723 | 5.76e-25 | 1.52e-22 | 223 |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
GO:0050821111 | Esophagus | ESCC | protein stabilization | 140/8552 | 191/18723 | 6.50e-15 | 3.61e-13 | 140 |
GO:000703314 | Esophagus | ESCC | vacuole organization | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:190503712 | Esophagus | ESCC | autophagosome organization | 73/8552 | 103/18723 | 1.88e-07 | 2.93e-06 | 73 |
GO:00482844 | Esophagus | ESCC | organelle fusion | 94/8552 | 141/18723 | 3.72e-07 | 5.16e-06 | 94 |
GO:00224069 | Esophagus | ESCC | membrane docking | 62/8552 | 86/18723 | 5.93e-07 | 7.79e-06 | 62 |
GO:000004513 | Esophagus | ESCC | autophagosome assembly | 69/8552 | 99/18723 | 1.10e-06 | 1.38e-05 | 69 |
GO:00901743 | Esophagus | ESCC | organelle membrane fusion | 73/8552 | 110/18723 | 9.29e-06 | 8.88e-05 | 73 |
GO:00069063 | Esophagus | ESCC | vesicle fusion | 70/8552 | 106/18723 | 1.82e-05 | 1.60e-04 | 70 |
GO:01400567 | Esophagus | ESCC | organelle localization by membrane tethering | 53/8552 | 77/18723 | 3.33e-05 | 2.74e-04 | 53 |
GO:00610254 | Esophagus | ESCC | membrane fusion | 98/8552 | 163/18723 | 1.39e-04 | 9.41e-04 | 98 |
GO:00482781 | Esophagus | ESCC | vesicle docking | 38/8552 | 59/18723 | 2.86e-03 | 1.21e-02 | 38 |
GO:003164712 | Liver | Cirrhotic | regulation of protein stability | 144/4634 | 298/18723 | 6.74e-19 | 1.28e-16 | 144 |
GO:005082112 | Liver | Cirrhotic | protein stabilization | 97/4634 | 191/18723 | 6.67e-15 | 6.97e-13 | 97 |
GO:001605011 | Liver | Cirrhotic | vesicle organization | 133/4634 | 300/18723 | 7.35e-14 | 6.41e-12 | 133 |
GO:001623611 | Liver | Cirrhotic | macroautophagy | 129/4634 | 291/18723 | 1.75e-13 | 1.41e-11 | 129 |
GO:00070332 | Liver | Cirrhotic | vacuole organization | 80/4634 | 180/18723 | 5.73e-09 | 2.25e-07 | 80 |
GO:00224065 | Liver | Cirrhotic | membrane docking | 39/4634 | 86/18723 | 2.47e-05 | 3.22e-04 | 39 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414530 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
hsa04145114 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
hsa0414514 | Liver | Cirrhotic | Phagosome | 73/2530 | 152/8465 | 1.61e-06 | 1.78e-05 | 1.10e-05 | 73 |
hsa0414515 | Liver | Cirrhotic | Phagosome | 73/2530 | 152/8465 | 1.61e-06 | 1.78e-05 | 1.10e-05 | 73 |
hsa0414521 | Liver | HCC | Phagosome | 93/4020 | 152/8465 | 4.27e-04 | 1.88e-03 | 1.05e-03 | 93 |
hsa0414531 | Liver | HCC | Phagosome | 93/4020 | 152/8465 | 4.27e-04 | 1.88e-03 | 1.05e-03 | 93 |
hsa0414528 | Oral cavity | OSCC | Phagosome | 88/3704 | 152/8465 | 2.83e-04 | 9.13e-04 | 4.65e-04 | 88 |
hsa04145113 | Oral cavity | OSCC | Phagosome | 88/3704 | 152/8465 | 2.83e-04 | 9.13e-04 | 4.65e-04 | 88 |
hsa0414529 | Oral cavity | LP | Phagosome | 73/2418 | 152/8465 | 2.37e-07 | 3.29e-06 | 2.12e-06 | 73 |
hsa0414536 | Oral cavity | LP | Phagosome | 73/2418 | 152/8465 | 2.37e-07 | 3.29e-06 | 2.12e-06 | 73 |
hsa0414543 | Oral cavity | EOLP | Phagosome | 38/1218 | 152/8465 | 3.42e-04 | 1.42e-03 | 8.35e-04 | 38 |
hsa0414553 | Oral cavity | EOLP | Phagosome | 38/1218 | 152/8465 | 3.42e-04 | 1.42e-03 | 8.35e-04 | 38 |
hsa0414561 | Oral cavity | NEOLP | Phagosome | 32/1112 | 152/8465 | 4.15e-03 | 1.67e-02 | 1.05e-02 | 32 |
hsa0414571 | Oral cavity | NEOLP | Phagosome | 32/1112 | 152/8465 | 4.15e-03 | 1.67e-02 | 1.05e-02 | 32 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STX12 | SNV | Missense_Mutation | c.354N>T | p.Gln118His | p.Q118H | Q86Y82 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D8-A147-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
STX12 | SNV | Missense_Mutation | rs377420642 | c.565C>T | p.Arg189Trp | p.R189W | Q86Y82 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
STX12 | deletion | In_Frame_Del | novel | c.40_45delCCCTCG | p.Pro14_Ser15del | p.P14_S15del | Q86Y82 | protein_coding | TCGA-AA-3532-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
STX12 | insertion | In_Frame_Ins | novel | c.617_618insTATTAA | p.Ala206_Met207insIleAsn | p.A206_M207insIN | Q86Y82 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
STX12 | SNV | Missense_Mutation | novel | c.132N>T | p.Lys44Asn | p.K44N | Q86Y82 | protein_coding | tolerated(0.07) | benign(0.091) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STX12 | SNV | Missense_Mutation | c.653N>T | p.Ser218Ile | p.S218I | Q86Y82 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
STX12 | SNV | Missense_Mutation | c.610N>T | p.Asp204Tyr | p.D204Y | Q86Y82 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
STX12 | SNV | Missense_Mutation | novel | c.289N>T | p.Arg97Cys | p.R97C | Q86Y82 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
STX12 | SNV | Missense_Mutation | novel | c.595N>G | p.Asn199Asp | p.N199D | Q86Y82 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STX12 | SNV | Missense_Mutation | novel | c.337N>A | p.Ala113Thr | p.A113T | Q86Y82 | protein_coding | tolerated(0.05) | probably_damaging(0.949) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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