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Gene: STK35 |
Gene summary for STK35 |
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Gene information | Species | Human | Gene symbol | STK35 | Gene ID | 140901 |
Gene name | serine/threonine kinase 35 | |
Gene Alias | CLIK1 | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q8TDR2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140901 | STK35 | P28T-E | Human | Esophagus | ESCC | 1.53e-16 | 2.78e-01 | 0.1149 |
140901 | STK35 | P30T-E | Human | Esophagus | ESCC | 2.08e-08 | 2.28e-01 | 0.137 |
140901 | STK35 | P31T-E | Human | Esophagus | ESCC | 6.38e-20 | 2.78e-01 | 0.1251 |
140901 | STK35 | P32T-E | Human | Esophagus | ESCC | 1.12e-07 | 6.24e-02 | 0.1666 |
140901 | STK35 | P36T-E | Human | Esophagus | ESCC | 3.21e-15 | 1.74e-01 | 0.1187 |
140901 | STK35 | P37T-E | Human | Esophagus | ESCC | 1.63e-17 | 1.27e-01 | 0.1371 |
140901 | STK35 | P39T-E | Human | Esophagus | ESCC | 5.13e-05 | 4.20e-02 | 0.0894 |
140901 | STK35 | P40T-E | Human | Esophagus | ESCC | 1.51e-05 | 7.85e-02 | 0.109 |
140901 | STK35 | P42T-E | Human | Esophagus | ESCC | 4.22e-08 | 8.22e-02 | 0.1175 |
140901 | STK35 | P47T-E | Human | Esophagus | ESCC | 2.01e-10 | 1.40e-01 | 0.1067 |
140901 | STK35 | P48T-E | Human | Esophagus | ESCC | 3.71e-09 | 1.28e-01 | 0.0959 |
140901 | STK35 | P49T-E | Human | Esophagus | ESCC | 5.11e-05 | 3.23e-01 | 0.1768 |
140901 | STK35 | P52T-E | Human | Esophagus | ESCC | 6.58e-19 | 2.38e-01 | 0.1555 |
140901 | STK35 | P54T-E | Human | Esophagus | ESCC | 2.42e-13 | 1.90e-01 | 0.0975 |
140901 | STK35 | P56T-E | Human | Esophagus | ESCC | 3.19e-06 | 4.40e-01 | 0.1613 |
140901 | STK35 | P57T-E | Human | Esophagus | ESCC | 1.05e-13 | 1.04e-01 | 0.0926 |
140901 | STK35 | P61T-E | Human | Esophagus | ESCC | 1.47e-09 | 1.31e-01 | 0.099 |
140901 | STK35 | P62T-E | Human | Esophagus | ESCC | 5.00e-20 | 2.87e-01 | 0.1302 |
140901 | STK35 | P65T-E | Human | Esophagus | ESCC | 9.78e-15 | 1.74e-01 | 0.0978 |
140901 | STK35 | P74T-E | Human | Esophagus | ESCC | 1.54e-05 | 6.62e-02 | 0.1479 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STK35 | SNV | Missense_Mutation | novel | c.1255N>T | p.Asp419Tyr | p.D419Y | Q8TDR2 | protein_coding | deleterious(0) | benign(0.27) | TCGA-A2-A04P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD |
STK35 | SNV | Missense_Mutation | novel | c.1594T>G | p.Cys532Gly | p.C532G | Q8TDR2 | protein_coding | deleterious_low_confidence(0) | benign(0.076) | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
STK35 | SNV | Missense_Mutation | rs138789925 | c.1196N>G | p.Asn399Ser | p.N399S | Q8TDR2 | protein_coding | tolerated(0.38) | benign(0.023) | TCGA-A2-A0T1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Targeted Molecular therapy | herceptin | SD |
STK35 | SNV | Missense_Mutation | novel | c.744N>A | p.Phe248Leu | p.F248L | Q8TDR2 | protein_coding | tolerated(0.27) | benign(0.055) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STK35 | SNV | Missense_Mutation | c.1577G>T | p.Arg526Ile | p.R526I | Q8TDR2 | protein_coding | deleterious(0) | possibly_damaging(0.81) | TCGA-BH-A0H5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
STK35 | SNV | Missense_Mutation | novel | c.1322N>T | p.Gly441Val | p.G441V | Q8TDR2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A27L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin+cuclophosphamide | SD |
STK35 | SNV | Missense_Mutation | c.1495N>G | p.Ser499Ala | p.S499A | Q8TDR2 | protein_coding | tolerated(0.06) | benign(0.18) | TCGA-E9-A1ND-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD | |
STK35 | insertion | Nonsense_Mutation | novel | c.1595_1596insCAGCAGGCCTAGGGAGAGGGATCACTTCAAATAGGAATAGCC | p.Cys532_Ala533insSerArgProArgGluArgAspHisPheLysTerGluTerPro | p.C532_A533insSRPRERDHFK*E*P | Q8TDR2 | protein_coding | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
STK35 | insertion | Nonsense_Mutation | novel | c.1471_1472insGTGTCATACCTTAGAAAGGCACTCAGTGCCAGTTGTGCAGGT | p.Pro491delinsArgValIleProTerLysGlyThrGlnCysGlnLeuCysArgSer | p.P491delinsRVIP*KGTQCQLCRS | Q8TDR2 | protein_coding | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | ||
STK35 | SNV | Missense_Mutation | c.926N>A | p.Cys309Tyr | p.C309Y | Q8TDR2 | protein_coding | tolerated(0.3) | benign(0.115) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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