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Gene: STIM2 |
Gene summary for STIM2 |
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Gene information | Species | Human | Gene symbol | STIM2 | Gene ID | 57620 |
Gene name | stromal interaction molecule 2 | |
Gene Alias | STIM2 | |
Cytomap | 4p15.2 | |
Gene Type | protein-coding | GO ID | GO:0002115 | UniProtAcc | B3KUB5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57620 | STIM2 | P24T-E | Human | Esophagus | ESCC | 1.73e-06 | 2.62e-02 | 0.1287 |
57620 | STIM2 | P26T-E | Human | Esophagus | ESCC | 2.23e-11 | 7.34e-02 | 0.1276 |
57620 | STIM2 | P27T-E | Human | Esophagus | ESCC | 2.29e-12 | 2.11e-01 | 0.1055 |
57620 | STIM2 | P28T-E | Human | Esophagus | ESCC | 1.04e-06 | 3.58e-02 | 0.1149 |
57620 | STIM2 | P30T-E | Human | Esophagus | ESCC | 2.46e-15 | 5.84e-01 | 0.137 |
57620 | STIM2 | P31T-E | Human | Esophagus | ESCC | 4.31e-13 | 1.60e-01 | 0.1251 |
57620 | STIM2 | P32T-E | Human | Esophagus | ESCC | 1.74e-12 | 2.65e-01 | 0.1666 |
57620 | STIM2 | P36T-E | Human | Esophagus | ESCC | 1.91e-14 | 1.70e-01 | 0.1187 |
57620 | STIM2 | P37T-E | Human | Esophagus | ESCC | 8.81e-18 | 2.97e-01 | 0.1371 |
57620 | STIM2 | P39T-E | Human | Esophagus | ESCC | 2.14e-09 | 7.57e-02 | 0.0894 |
57620 | STIM2 | P40T-E | Human | Esophagus | ESCC | 6.90e-05 | 1.16e-01 | 0.109 |
57620 | STIM2 | P42T-E | Human | Esophagus | ESCC | 1.72e-08 | 1.09e-01 | 0.1175 |
57620 | STIM2 | P44T-E | Human | Esophagus | ESCC | 4.30e-05 | 1.14e-01 | 0.1096 |
57620 | STIM2 | P47T-E | Human | Esophagus | ESCC | 7.57e-06 | 8.96e-02 | 0.1067 |
57620 | STIM2 | P48T-E | Human | Esophagus | ESCC | 1.41e-08 | 1.59e-01 | 0.0959 |
57620 | STIM2 | P52T-E | Human | Esophagus | ESCC | 7.89e-17 | 1.56e-01 | 0.1555 |
57620 | STIM2 | P54T-E | Human | Esophagus | ESCC | 4.26e-09 | 8.77e-02 | 0.0975 |
57620 | STIM2 | P56T-E | Human | Esophagus | ESCC | 4.01e-03 | 7.54e-01 | 0.1613 |
57620 | STIM2 | P57T-E | Human | Esophagus | ESCC | 7.53e-06 | 2.45e-01 | 0.0926 |
57620 | STIM2 | P61T-E | Human | Esophagus | ESCC | 2.11e-13 | 5.08e-02 | 0.099 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00725032 | Oral cavity | EOLP | cellular divalent inorganic cation homeostasis | 75/2218 | 486/18723 | 9.77e-03 | 4.42e-02 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STIM2 | SNV | Missense_Mutation | novel | c.1321C>T | p.Arg441Cys | p.R441C | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STIM2 | insertion | Nonsense_Mutation | novel | c.1097_1098insGTCTCATACCTGTAATCTCAG | p.Tyr366delinsTer | p.Y366delins* | protein_coding | TCGA-A2-A0EV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
STIM2 | deletion | Frame_Shift_Del | novel | c.855delN | p.Leu286Ter | p.L286* | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |||
STIM2 | SNV | Missense_Mutation | rs150484445 | c.2105G>A | p.Arg702His | p.R702H | protein_coding | tolerated_low_confidence(0.08) | benign(0.04) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
STIM2 | SNV | Missense_Mutation | c.1756N>C | p.Glu586Gln | p.E586Q | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.815) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | ||
STIM2 | SNV | Missense_Mutation | novel | c.1964N>G | p.Ser655Cys | p.S655C | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.628) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
STIM2 | SNV | Missense_Mutation | c.1724N>T | p.Cys575Phe | p.C575F | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.896) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
STIM2 | insertion | In_Frame_Ins | novel | c.1275-1_1275insAATTTT | p.Lys425_Lys426insIleLeu | p.K425_K426insIL | protein_coding | TCGA-EX-A69M-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |||
STIM2 | SNV | Missense_Mutation | c.649G>T | p.Asp217Tyr | p.D217Y | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | ||
STIM2 | SNV | Missense_Mutation | c.1748N>T | p.Glu583Val | p.E583V | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.915) | TCGA-AA-3684-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
57620 | STIM2 | DRUGGABLE GENOME | AMINOGLYCOSIDE ANTIBIOTIC | 17905723 |
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