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Gene: STAMBP |
Gene summary for STAMBP |
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Gene information | Species | Human | Gene symbol | STAMBP | Gene ID | 10617 |
Gene name | STAM binding protein | |
Gene Alias | AMSH | |
Cytomap | 2p13.1 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | A0A140VK54 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10617 | STAMBP | P12T-E | Human | Esophagus | ESCC | 1.32e-25 | 5.29e-01 | 0.1122 |
10617 | STAMBP | P15T-E | Human | Esophagus | ESCC | 3.99e-31 | 6.47e-01 | 0.1149 |
10617 | STAMBP | P16T-E | Human | Esophagus | ESCC | 4.99e-43 | 8.55e-01 | 0.1153 |
10617 | STAMBP | P17T-E | Human | Esophagus | ESCC | 9.54e-17 | 7.70e-01 | 0.1278 |
10617 | STAMBP | P19T-E | Human | Esophagus | ESCC | 2.43e-11 | 7.52e-01 | 0.1662 |
10617 | STAMBP | P20T-E | Human | Esophagus | ESCC | 1.48e-33 | 7.12e-01 | 0.1124 |
10617 | STAMBP | P21T-E | Human | Esophagus | ESCC | 6.36e-35 | 8.09e-01 | 0.1617 |
10617 | STAMBP | P22T-E | Human | Esophagus | ESCC | 2.24e-36 | 6.66e-01 | 0.1236 |
10617 | STAMBP | P23T-E | Human | Esophagus | ESCC | 2.20e-33 | 9.48e-01 | 0.108 |
10617 | STAMBP | P24T-E | Human | Esophagus | ESCC | 8.59e-23 | 5.59e-01 | 0.1287 |
10617 | STAMBP | P26T-E | Human | Esophagus | ESCC | 1.19e-32 | 6.77e-01 | 0.1276 |
10617 | STAMBP | P27T-E | Human | Esophagus | ESCC | 9.64e-35 | 6.44e-01 | 0.1055 |
10617 | STAMBP | P28T-E | Human | Esophagus | ESCC | 2.20e-36 | 8.38e-01 | 0.1149 |
10617 | STAMBP | P30T-E | Human | Esophagus | ESCC | 8.15e-21 | 1.00e+00 | 0.137 |
10617 | STAMBP | P31T-E | Human | Esophagus | ESCC | 5.39e-29 | 3.91e-01 | 0.1251 |
10617 | STAMBP | P32T-E | Human | Esophagus | ESCC | 1.60e-31 | 7.44e-01 | 0.1666 |
10617 | STAMBP | P36T-E | Human | Esophagus | ESCC | 9.43e-21 | 7.04e-01 | 0.1187 |
10617 | STAMBP | P37T-E | Human | Esophagus | ESCC | 8.02e-19 | 4.75e-01 | 0.1371 |
10617 | STAMBP | P38T-E | Human | Esophagus | ESCC | 8.21e-22 | 8.08e-01 | 0.127 |
10617 | STAMBP | P39T-E | Human | Esophagus | ESCC | 1.08e-22 | 3.73e-01 | 0.0894 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000091015 | Esophagus | HGIN | cytokinesis | 44/2587 | 173/18723 | 3.26e-05 | 8.32e-04 | 44 |
GO:00616406 | Esophagus | HGIN | cytoskeleton-dependent cytokinesis | 27/2587 | 100/18723 | 3.71e-04 | 5.77e-03 | 27 |
GO:00002816 | Esophagus | HGIN | mitotic cytokinesis | 19/2587 | 71/18723 | 2.90e-03 | 2.81e-02 | 19 |
GO:00706463 | Esophagus | HGIN | protein modification by small protein removal | 34/2587 | 157/18723 | 4.68e-03 | 4.02e-02 | 34 |
GO:000028115 | Esophagus | ESCC | mitotic cytokinesis | 58/8552 | 71/18723 | 4.34e-10 | 1.15e-08 | 58 |
GO:000091016 | Esophagus | ESCC | cytokinesis | 115/8552 | 173/18723 | 2.48e-08 | 4.68e-07 | 115 |
GO:006164015 | Esophagus | ESCC | cytoskeleton-dependent cytokinesis | 72/8552 | 100/18723 | 8.10e-08 | 1.39e-06 | 72 |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:007064612 | Esophagus | ESCC | protein modification by small protein removal | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:00465789 | Esophagus | ESCC | regulation of Ras protein signal transduction | 106/8552 | 189/18723 | 2.49e-03 | 1.08e-02 | 106 |
GO:00165793 | Esophagus | ESCC | protein deubiquitination | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
GO:005105610 | Esophagus | ESCC | regulation of small GTPase mediated signal transduction | 157/8552 | 302/18723 | 1.55e-02 | 4.98e-02 | 157 |
GO:000028111 | Liver | HCC | mitotic cytokinesis | 51/7958 | 71/18723 | 5.20e-07 | 8.38e-06 | 51 |
GO:000726521 | Liver | HCC | Ras protein signal transduction | 187/7958 | 337/18723 | 8.89e-07 | 1.35e-05 | 187 |
GO:000091011 | Liver | HCC | cytokinesis | 100/7958 | 173/18723 | 3.38e-05 | 3.39e-04 | 100 |
GO:00706461 | Liver | HCC | protein modification by small protein removal | 91/7958 | 157/18723 | 6.50e-05 | 5.92e-04 | 91 |
GO:006164011 | Liver | HCC | cytoskeleton-dependent cytokinesis | 60/7958 | 100/18723 | 3.09e-04 | 2.20e-03 | 60 |
GO:00165791 | Liver | HCC | protein deubiquitination | 78/7958 | 139/18723 | 8.13e-04 | 4.87e-03 | 78 |
GO:00705361 | Liver | HCC | protein K63-linked deubiquitination | 24/7958 | 35/18723 | 1.64e-03 | 8.61e-03 | 24 |
GO:004657811 | Liver | HCC | regulation of Ras protein signal transduction | 100/7958 | 189/18723 | 2.42e-03 | 1.18e-02 | 100 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414429 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa04144113 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa0414428 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
hsa0414436 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STAMBP | SNV | Missense_Mutation | c.103N>T | p.Arg35Trp | p.R35W | O95630 | protein_coding | deleterious(0.01) | benign(0.344) | TCGA-A8-A09Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
STAMBP | SNV | Missense_Mutation | novel | c.312A>C | p.Glu104Asp | p.E104D | O95630 | protein_coding | tolerated(0.53) | benign(0.019) | TCGA-E9-A3X8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphane | CR |
STAMBP | deletion | Frame_Shift_Del | novel | c.239delA | p.Tyr80SerfsTer13 | p.Y80Sfs*13 | O95630 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
STAMBP | deletion | Frame_Shift_Del | novel | c.668delN | p.Thr223LysfsTer3 | p.T223Kfs*3 | O95630 | protein_coding | TCGA-OL-A5RU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR | ||
STAMBP | SNV | Missense_Mutation | c.1128N>A | p.Phe376Leu | p.F376L | O95630 | protein_coding | tolerated(0.09) | benign(0.025) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
STAMBP | SNV | Missense_Mutation | rs766533447 | c.533N>A | p.Arg178Gln | p.R178Q | O95630 | protein_coding | tolerated(0.44) | benign(0.251) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STAMBP | SNV | Missense_Mutation | rs750544616 | c.488N>G | p.His163Arg | p.H163R | O95630 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
STAMBP | SNV | Missense_Mutation | novel | c.730A>C | p.Asn244His | p.N244H | O95630 | protein_coding | deleterious(0.01) | benign(0.001) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD |
STAMBP | SNV | Missense_Mutation | c.794C>A | p.Pro265Gln | p.P265Q | O95630 | protein_coding | tolerated(0.44) | benign(0.007) | TCGA-CM-4750-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | SD | |
STAMBP | SNV | Missense_Mutation | c.1043A>G | p.Asp348Gly | p.D348G | O95630 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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