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Gene: SSBP2 |
Gene summary for SSBP2 |
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Gene information | Species | Human | Gene symbol | SSBP2 | Gene ID | 23635 |
Gene name | single stranded DNA binding protein 2 | |
Gene Alias | HSPC116 | |
Cytomap | 5q14.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A087X159 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23635 | SSBP2 | P12T-E | Human | Esophagus | ESCC | 5.43e-27 | 6.02e-01 | 0.1122 |
23635 | SSBP2 | P15T-E | Human | Esophagus | ESCC | 1.98e-17 | 4.00e-01 | 0.1149 |
23635 | SSBP2 | P16T-E | Human | Esophagus | ESCC | 9.50e-11 | 5.08e-02 | 0.1153 |
23635 | SSBP2 | P17T-E | Human | Esophagus | ESCC | 1.71e-04 | 4.02e-01 | 0.1278 |
23635 | SSBP2 | P20T-E | Human | Esophagus | ESCC | 3.30e-36 | 7.42e-01 | 0.1124 |
23635 | SSBP2 | P21T-E | Human | Esophagus | ESCC | 5.70e-07 | 9.38e-02 | 0.1617 |
23635 | SSBP2 | P22T-E | Human | Esophagus | ESCC | 7.15e-15 | 1.20e-01 | 0.1236 |
23635 | SSBP2 | P23T-E | Human | Esophagus | ESCC | 1.09e-36 | 8.78e-01 | 0.108 |
23635 | SSBP2 | P24T-E | Human | Esophagus | ESCC | 1.44e-08 | 4.99e-02 | 0.1287 |
23635 | SSBP2 | P26T-E | Human | Esophagus | ESCC | 2.84e-40 | 8.02e-01 | 0.1276 |
23635 | SSBP2 | P27T-E | Human | Esophagus | ESCC | 1.53e-23 | 5.68e-01 | 0.1055 |
23635 | SSBP2 | P28T-E | Human | Esophagus | ESCC | 7.50e-06 | -3.14e-02 | 0.1149 |
23635 | SSBP2 | P30T-E | Human | Esophagus | ESCC | 4.64e-16 | 3.76e-01 | 0.137 |
23635 | SSBP2 | P32T-E | Human | Esophagus | ESCC | 1.60e-20 | 2.66e-01 | 0.1666 |
23635 | SSBP2 | P36T-E | Human | Esophagus | ESCC | 7.68e-22 | 6.51e-01 | 0.1187 |
23635 | SSBP2 | P37T-E | Human | Esophagus | ESCC | 3.79e-15 | 2.17e-01 | 0.1371 |
23635 | SSBP2 | P38T-E | Human | Esophagus | ESCC | 1.13e-02 | 2.24e-02 | 0.127 |
23635 | SSBP2 | P39T-E | Human | Esophagus | ESCC | 5.71e-17 | 1.78e-01 | 0.0894 |
23635 | SSBP2 | P40T-E | Human | Esophagus | ESCC | 6.70e-13 | 2.83e-01 | 0.109 |
23635 | SSBP2 | P42T-E | Human | Esophagus | ESCC | 1.72e-13 | 2.11e-01 | 0.1175 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SSBP2 | SNV | Missense_Mutation | novel | c.1071N>C | p.Gln357His | p.Q357H | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.978) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |
SSBP2 | SNV | Missense_Mutation | c.408N>C | p.Arg136Ser | p.R136S | protein_coding | deleterious(0.03) | benign(0.105) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SSBP2 | SNV | Missense_Mutation | novel | c.866N>T | p.Arg289Ile | p.R289I | protein_coding | deleterious(0.01) | probably_damaging(0.929) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SSBP2 | SNV | Missense_Mutation | novel | c.530N>T | p.Arg177Ile | p.R177I | protein_coding | deleterious(0.03) | probably_damaging(0.978) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SSBP2 | SNV | Missense_Mutation | c.882N>T | p.Met294Ile | p.M294I | protein_coding | tolerated(0.11) | benign(0.001) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
SSBP2 | deletion | Frame_Shift_Del | novel | c.626delN | p.Asn209MetfsTer3 | p.N209Mfs*3 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
SSBP2 | SNV | Missense_Mutation | c.890N>T | p.Gly297Val | p.G297V | protein_coding | deleterious(0) | possibly_damaging(0.771) | TCGA-BI-A0VS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
SSBP2 | SNV | Missense_Mutation | c.752N>T | p.Pro251Leu | p.P251L | protein_coding | deleterious(0.03) | possibly_damaging(0.477) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SSBP2 | SNV | Missense_Mutation | c.76N>A | p.Val26Ile | p.V26I | protein_coding | tolerated(0.05) | possibly_damaging(0.682) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
SSBP2 | SNV | Missense_Mutation | c.984N>G | p.Asn328Lys | p.N328K | protein_coding | deleterious(0.01) | benign(0.343) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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