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Gene: SOX7 |
Gene summary for SOX7 |
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Gene information | Species | Human | Gene symbol | SOX7 | Gene ID | 83595 |
Gene name | SRY-box transcription factor 7 | |
Gene Alias | SOX7 | |
Cytomap | 8p23.1 | |
Gene Type | protein-coding | GO ID | GO:0001704 | UniProtAcc | Q9BT81 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83595 | SOX7 | P36T-E | Human | Esophagus | ESCC | 3.75e-05 | 8.46e-01 | 0.1187 |
83595 | SOX7 | P37T-E | Human | Esophagus | ESCC | 2.70e-14 | -2.74e-01 | 0.1371 |
83595 | SOX7 | P39T-E | Human | Esophagus | ESCC | 2.29e-13 | -3.66e-01 | 0.0894 |
83595 | SOX7 | P40T-E | Human | Esophagus | ESCC | 4.26e-02 | -9.76e-02 | 0.109 |
83595 | SOX7 | P42T-E | Human | Esophagus | ESCC | 1.15e-15 | 8.09e-01 | 0.1175 |
83595 | SOX7 | P47T-E | Human | Esophagus | ESCC | 8.69e-07 | 1.87e-01 | 0.1067 |
83595 | SOX7 | P48T-E | Human | Esophagus | ESCC | 3.64e-06 | 2.79e-01 | 0.0959 |
83595 | SOX7 | P54T-E | Human | Esophagus | ESCC | 4.10e-11 | 7.31e-01 | 0.0975 |
83595 | SOX7 | P61T-E | Human | Esophagus | ESCC | 1.20e-03 | 3.67e-01 | 0.099 |
83595 | SOX7 | P62T-E | Human | Esophagus | ESCC | 1.11e-07 | 2.17e-01 | 0.1302 |
83595 | SOX7 | P65T-E | Human | Esophagus | ESCC | 1.73e-02 | 5.38e-02 | 0.0978 |
83595 | SOX7 | P74T-E | Human | Esophagus | ESCC | 1.15e-09 | 9.11e-01 | 0.1479 |
83595 | SOX7 | P79T-E | Human | Esophagus | ESCC | 1.93e-03 | 4.36e-01 | 0.1154 |
83595 | SOX7 | P80T-E | Human | Esophagus | ESCC | 1.90e-22 | 1.29e+00 | 0.155 |
83595 | SOX7 | P83T-E | Human | Esophagus | ESCC | 4.24e-11 | 4.40e-01 | 0.1738 |
83595 | SOX7 | P89T-E | Human | Esophagus | ESCC | 1.44e-04 | 1.23e+00 | 0.1752 |
83595 | SOX7 | P127T-E | Human | Esophagus | ESCC | 7.56e-03 | -3.30e-01 | 0.0826 |
83595 | SOX7 | P130T-E | Human | Esophagus | ESCC | 6.84e-05 | -1.16e-01 | 0.1676 |
83595 | SOX7 | HCC1 | Human | Liver | HCC | 4.28e-02 | 1.02e+00 | 0.5336 |
83595 | SOX7 | HCC2 | Human | Liver | HCC | 3.11e-04 | 6.15e-01 | 0.5341 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004586227 | Esophagus | HGIN | positive regulation of proteolysis | 107/2587 | 372/18723 | 2.61e-14 | 4.60e-12 | 107 |
GO:004328126 | Esophagus | HGIN | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 59/2587 | 209/18723 | 3.39e-08 | 1.97e-06 | 59 |
GO:200011626 | Esophagus | HGIN | regulation of cysteine-type endopeptidase activity | 63/2587 | 235/18723 | 9.71e-08 | 5.02e-06 | 63 |
GO:005254726 | Esophagus | HGIN | regulation of peptidase activity | 102/2587 | 461/18723 | 6.29e-07 | 2.72e-05 | 102 |
GO:001095225 | Esophagus | HGIN | positive regulation of peptidase activity | 53/2587 | 197/18723 | 8.70e-07 | 3.59e-05 | 53 |
GO:005254826 | Esophagus | HGIN | regulation of endopeptidase activity | 96/2587 | 432/18723 | 1.09e-06 | 4.30e-05 | 96 |
GO:004328020 | Esophagus | HGIN | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 38/2587 | 129/18723 | 2.92e-06 | 1.01e-04 | 38 |
GO:200105620 | Esophagus | HGIN | positive regulation of cysteine-type endopeptidase activity | 41/2587 | 148/18723 | 6.65e-06 | 2.07e-04 | 41 |
GO:001095020 | Esophagus | HGIN | positive regulation of endopeptidase activity | 47/2587 | 179/18723 | 7.23e-06 | 2.20e-04 | 47 |
GO:003011116 | Esophagus | HGIN | regulation of Wnt signaling pathway | 65/2587 | 328/18723 | 1.53e-03 | 1.77e-02 | 65 |
GO:001605516 | Esophagus | HGIN | Wnt signaling pathway | 83/2587 | 444/18723 | 2.27e-03 | 2.33e-02 | 83 |
GO:019873816 | Esophagus | HGIN | cell-cell signaling by wnt | 83/2587 | 446/18723 | 2.58e-03 | 2.55e-02 | 83 |
GO:006082816 | Esophagus | HGIN | regulation of canonical Wnt signaling pathway | 50/2587 | 253/18723 | 5.27e-03 | 4.35e-02 | 50 |
GO:0045862111 | Esophagus | ESCC | positive regulation of proteolysis | 256/8552 | 372/18723 | 7.88e-20 | 9.43e-18 | 256 |
GO:2000116111 | Esophagus | ESCC | regulation of cysteine-type endopeptidase activity | 158/8552 | 235/18723 | 1.67e-11 | 5.90e-10 | 158 |
GO:0043281111 | Esophagus | ESCC | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 143/8552 | 209/18723 | 2.12e-11 | 7.31e-10 | 143 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:0010952111 | Esophagus | ESCC | positive regulation of peptidase activity | 133/8552 | 197/18723 | 4.31e-10 | 1.14e-08 | 133 |
GO:0052547111 | Esophagus | ESCC | regulation of peptidase activity | 275/8552 | 461/18723 | 7.54e-10 | 1.88e-08 | 275 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SOX7 | SNV | Missense_Mutation | c.940G>A | p.Ala314Thr | p.A314T | Q9BT81 | protein_coding | tolerated(1) | benign(0.006) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SOX7 | SNV | Missense_Mutation | novel | c.315N>A | p.His105Gln | p.H105Q | Q9BT81 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SOX7 | SNV | Missense_Mutation | c.813N>T | p.Met271Ile | p.M271I | Q9BT81 | protein_coding | tolerated(0.82) | benign(0) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
SOX7 | SNV | Missense_Mutation | novel | c.295N>A | p.Glu99Lys | p.E99K | Q9BT81 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR |
SOX7 | SNV | Missense_Mutation | novel | c.793N>C | p.Ser265Pro | p.S265P | Q9BT81 | protein_coding | tolerated(0.25) | benign(0.009) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SOX7 | SNV | Missense_Mutation | c.293C>T | p.Ala98Val | p.A98V | Q9BT81 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SOX7 | SNV | Missense_Mutation | c.724N>C | p.Tyr242His | p.Y242H | Q9BT81 | protein_coding | tolerated(0.13) | benign(0.029) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SOX7 | SNV | Missense_Mutation | rs142748053 | c.457N>T | p.Arg153Trp | p.R153W | Q9BT81 | protein_coding | deleterious(0.02) | possibly_damaging(0.462) | TCGA-D5-6926-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
SOX7 | SNV | Missense_Mutation | rs767524561 | c.395N>A | p.Gly132Asp | p.G132D | Q9BT81 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-DM-A1D7-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SOX7 | SNV | Missense_Mutation | rs746671600 | c.961G>A | p.Val321Met | p.V321M | Q9BT81 | protein_coding | deleterious(0.01) | possibly_damaging(0.852) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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