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Gene: SMIM15 |
Gene summary for SMIM15 |
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Gene information | Species | Human | Gene symbol | SMIM15 | Gene ID | 643155 |
Gene name | small integral membrane protein 15 | |
Gene Alias | C5orf43 | |
Cytomap | 5q12.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q7Z3B0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
643155 | SMIM15 | P15T-E | Human | Esophagus | ESCC | 4.91e-33 | 7.92e-01 | 0.1149 |
643155 | SMIM15 | P16T-E | Human | Esophagus | ESCC | 3.51e-27 | 4.83e-01 | 0.1153 |
643155 | SMIM15 | P17T-E | Human | Esophagus | ESCC | 5.73e-10 | 4.49e-01 | 0.1278 |
643155 | SMIM15 | P19T-E | Human | Esophagus | ESCC | 2.13e-10 | 1.06e+00 | 0.1662 |
643155 | SMIM15 | P20T-E | Human | Esophagus | ESCC | 6.35e-31 | 7.35e-01 | 0.1124 |
643155 | SMIM15 | P21T-E | Human | Esophagus | ESCC | 9.38e-43 | 9.56e-01 | 0.1617 |
643155 | SMIM15 | P22T-E | Human | Esophagus | ESCC | 7.10e-39 | 6.72e-01 | 0.1236 |
643155 | SMIM15 | P23T-E | Human | Esophagus | ESCC | 3.30e-29 | 7.75e-01 | 0.108 |
643155 | SMIM15 | P24T-E | Human | Esophagus | ESCC | 5.70e-23 | 6.46e-01 | 0.1287 |
643155 | SMIM15 | P26T-E | Human | Esophagus | ESCC | 1.22e-45 | 7.85e-01 | 0.1276 |
643155 | SMIM15 | P27T-E | Human | Esophagus | ESCC | 1.53e-20 | 5.33e-01 | 0.1055 |
643155 | SMIM15 | P28T-E | Human | Esophagus | ESCC | 1.69e-18 | 4.61e-01 | 0.1149 |
643155 | SMIM15 | P30T-E | Human | Esophagus | ESCC | 1.09e-42 | 1.28e+00 | 0.137 |
643155 | SMIM15 | P31T-E | Human | Esophagus | ESCC | 1.05e-19 | 4.11e-01 | 0.1251 |
643155 | SMIM15 | P32T-E | Human | Esophagus | ESCC | 2.69e-28 | 6.43e-01 | 0.1666 |
643155 | SMIM15 | P36T-E | Human | Esophagus | ESCC | 4.34e-24 | 9.15e-01 | 0.1187 |
643155 | SMIM15 | P37T-E | Human | Esophagus | ESCC | 1.99e-25 | 5.71e-01 | 0.1371 |
643155 | SMIM15 | P38T-E | Human | Esophagus | ESCC | 7.92e-16 | 8.75e-01 | 0.127 |
643155 | SMIM15 | P39T-E | Human | Esophagus | ESCC | 1.55e-22 | 3.61e-01 | 0.0894 |
643155 | SMIM15 | P40T-E | Human | Esophagus | ESCC | 4.46e-11 | 3.07e-01 | 0.109 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SMIM15 | SNV | Missense_Mutation | rs201138177 | c.181C>T | p.Arg61Cys | p.R61C | Q7Z3B0 | protein_coding | tolerated(0.2) | possibly_damaging(0.656) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SMIM15 | SNV | Missense_Mutation | novel | c.140N>C | p.Met47Thr | p.M47T | Q7Z3B0 | protein_coding | tolerated(0.21) | benign(0.017) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SMIM15 | SNV | Missense_Mutation | novel | c.8N>C | p.Asp3Ala | p.D3A | Q7Z3B0 | protein_coding | deleterious(0.04) | benign(0.325) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SMIM15 | SNV | Missense_Mutation | novel | c.67N>A | p.Leu23Ile | p.L23I | Q7Z3B0 | protein_coding | tolerated(0.23) | probably_damaging(0.978) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SMIM15 | SNV | Missense_Mutation | novel | c.51N>T | p.Lys17Asn | p.K17N | Q7Z3B0 | protein_coding | tolerated(0.09) | benign(0.052) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SMIM15 | SNV | Missense_Mutation | novel | c.116N>C | p.Val39Ala | p.V39A | Q7Z3B0 | protein_coding | tolerated(0.09) | benign(0) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
SMIM15 | SNV | Missense_Mutation | novel | c.219N>T | p.Lys73Asn | p.K73N | Q7Z3B0 | protein_coding | tolerated(0.08) | probably_damaging(0.991) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
SMIM15 | SNV | Missense_Mutation | novel | c.156N>T | p.Glu52Asp | p.E52D | Q7Z3B0 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SMIM15 | SNV | Missense_Mutation | c.28N>C | p.Tyr10His | p.Y10H | Q7Z3B0 | protein_coding | tolerated(0.15) | probably_damaging(0.994) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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