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Gene: SLX4IP |
Gene summary for SLX4IP |
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Gene information | Species | Human | Gene symbol | SLX4IP | Gene ID | 128710 |
Gene name | SLX4 interacting protein | |
Gene Alias | C20orf94 | |
Cytomap | 20p12.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q5VYV7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
128710 | SLX4IP | P24T-E | Human | Esophagus | ESCC | 1.89e-09 | 1.83e-01 | 0.1287 |
128710 | SLX4IP | P26T-E | Human | Esophagus | ESCC | 7.39e-24 | 4.47e-01 | 0.1276 |
128710 | SLX4IP | P27T-E | Human | Esophagus | ESCC | 4.35e-13 | 1.65e-01 | 0.1055 |
128710 | SLX4IP | P28T-E | Human | Esophagus | ESCC | 2.96e-12 | 2.73e-01 | 0.1149 |
128710 | SLX4IP | P30T-E | Human | Esophagus | ESCC | 8.80e-09 | 3.51e-01 | 0.137 |
128710 | SLX4IP | P31T-E | Human | Esophagus | ESCC | 1.54e-23 | 2.42e-01 | 0.1251 |
128710 | SLX4IP | P32T-E | Human | Esophagus | ESCC | 6.09e-05 | 8.62e-02 | 0.1666 |
128710 | SLX4IP | P36T-E | Human | Esophagus | ESCC | 2.75e-05 | 1.93e-01 | 0.1187 |
128710 | SLX4IP | P39T-E | Human | Esophagus | ESCC | 3.89e-10 | 9.80e-02 | 0.0894 |
128710 | SLX4IP | P40T-E | Human | Esophagus | ESCC | 1.93e-02 | 1.47e-01 | 0.109 |
128710 | SLX4IP | P47T-E | Human | Esophagus | ESCC | 2.39e-18 | 1.31e-01 | 0.1067 |
128710 | SLX4IP | P48T-E | Human | Esophagus | ESCC | 3.18e-09 | 1.02e-01 | 0.0959 |
128710 | SLX4IP | P49T-E | Human | Esophagus | ESCC | 4.54e-03 | 5.13e-01 | 0.1768 |
128710 | SLX4IP | P52T-E | Human | Esophagus | ESCC | 2.47e-09 | 1.50e-01 | 0.1555 |
128710 | SLX4IP | P54T-E | Human | Esophagus | ESCC | 1.53e-04 | 1.72e-01 | 0.0975 |
128710 | SLX4IP | P56T-E | Human | Esophagus | ESCC | 2.24e-05 | 5.62e-01 | 0.1613 |
128710 | SLX4IP | P57T-E | Human | Esophagus | ESCC | 8.25e-10 | 1.33e-01 | 0.0926 |
128710 | SLX4IP | P61T-E | Human | Esophagus | ESCC | 1.66e-04 | 1.51e-01 | 0.099 |
128710 | SLX4IP | P62T-E | Human | Esophagus | ESCC | 1.74e-13 | 3.11e-01 | 0.1302 |
128710 | SLX4IP | P65T-E | Human | Esophagus | ESCC | 2.95e-10 | 2.36e-01 | 0.0978 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLX4IP | insertion | In_Frame_Ins | novel | c.944_945insCCTTAACAT | p.Ser315_Asp316insLeuAsnIle | p.S315_D316insLNI | Q5VYV7 | protein_coding | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
SLX4IP | insertion | Frame_Shift_Ins | novel | c.946_947insGAAATGAATACCTATTTACCTT | p.Asp316GlyfsTer48 | p.D316Gfs*48 | Q5VYV7 | protein_coding | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
SLX4IP | insertion | Nonsense_Mutation | novel | c.1002_1003insAATACCTATTTACCTTAGTTAAAATGTGAACGCCATCATAAAT | p.Pro335AsnfsTer6 | p.P335Nfs*6 | Q5VYV7 | protein_coding | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
SLX4IP | insertion | Nonsense_Mutation | novel | c.778_779insTCTGCATTTAAACATACACCT | p.Gly260delinsValCysIleTerThrTyrThrTrp | p.G260delinsVCI*TYTW | Q5VYV7 | protein_coding | TCGA-BH-A0HU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | ||
SLX4IP | insertion | In_Frame_Ins | novel | c.1076_1077insAACTAA | p.Leu359_His360insThrLys | p.L359_H360insTK | Q5VYV7 | protein_coding | TCGA-BH-A0HY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | taxotere | CR | ||
SLX4IP | insertion | In_Frame_Ins | novel | c.1077_1078insTCCTACTCCCATTTGTTGATCAAGTTTGGTCAA | p.Leu359_His360insSerTyrSerHisLeuLeuIleLysPheGlyGln | p.L359_H360insSYSHLLIKFGQ | Q5VYV7 | protein_coding | TCGA-BH-A0HY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | taxotere | CR | ||
SLX4IP | deletion | Frame_Shift_Del | novel | c.273delN | p.Arg92GlufsTer37 | p.R92Efs*37 | Q5VYV7 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
SLX4IP | SNV | Missense_Mutation | novel | c.670N>C | p.Asp224His | p.D224H | Q5VYV7 | protein_coding | deleterious(0) | probably_damaging(0.912) | TCGA-AA-3695-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SLX4IP | SNV | Missense_Mutation | novel | c.575N>A | p.Thr192Lys | p.T192K | Q5VYV7 | protein_coding | tolerated(0.41) | benign(0.012) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
SLX4IP | SNV | Missense_Mutation | c.628N>A | p.Ala210Thr | p.A210T | Q5VYV7 | protein_coding | tolerated(0.77) | benign(0.104) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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