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Gene: SLC35G1 |
Gene summary for SLC35G1 |
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Gene information | Species | Human | Gene symbol | SLC35G1 | Gene ID | 159371 |
Gene name | solute carrier family 35 member G1 | |
Gene Alias | C10orf60 | |
Cytomap | 10q23.33 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q2M3R5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
159371 | SLC35G1 | P62T-E | Human | Esophagus | ESCC | 2.27e-07 | 1.71e-01 | 0.1302 |
159371 | SLC35G1 | P80T-E | Human | Esophagus | ESCC | 1.18e-11 | 3.45e-01 | 0.155 |
159371 | SLC35G1 | P83T-E | Human | Esophagus | ESCC | 1.21e-07 | 2.54e-01 | 0.1738 |
159371 | SLC35G1 | P107T-E | Human | Esophagus | ESCC | 9.56e-17 | 4.33e-01 | 0.171 |
159371 | SLC35G1 | P128T-E | Human | Esophagus | ESCC | 4.98e-03 | 1.63e-01 | 0.1241 |
159371 | SLC35G1 | Pat01-B | Human | Stomach | GC | 2.76e-27 | 5.66e-01 | 0.5754 |
159371 | SLC35G1 | Pat02-B | Human | Stomach | GC | 3.76e-03 | 9.81e-02 | 0.0368 |
159371 | SLC35G1 | Pat03-B | Human | Stomach | GC | 8.41e-13 | 3.87e-01 | 0.3693 |
159371 | SLC35G1 | SIM_1 | Human | Stomach | SIM | 1.67e-02 | 1.76e-01 | 0.3573 |
159371 | SLC35G1 | SIM_4 | Human | Stomach | SIM | 7.08e-03 | 2.78e-01 | 0.2664 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC35G1 | SNV | Missense_Mutation | novel | c.206N>T | p.Gly69Val | p.G69V | Q2M3R5 | protein_coding | deleterious(0.02) | probably_damaging(0.976) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
SLC35G1 | SNV | Missense_Mutation | rs144586382 | c.635C>T | p.Ser212Leu | p.S212L | Q2M3R5 | protein_coding | tolerated(0.4) | benign(0) | TCGA-GM-A3NY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
SLC35G1 | SNV | Missense_Mutation | rs781104049 | c.311G>A | p.Arg104Gln | p.R104Q | Q2M3R5 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC35G1 | SNV | Missense_Mutation | novel | c.629A>G | p.Asp210Gly | p.D210G | Q2M3R5 | protein_coding | tolerated(0.27) | benign(0.003) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC35G1 | insertion | Frame_Shift_Ins | novel | c.624_625insAAGCATAG | p.Ser209LysfsTer34 | p.S209Kfs*34 | Q2M3R5 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SLC35G1 | SNV | Missense_Mutation | novel | c.916N>T | p.Leu306Phe | p.L306F | Q2M3R5 | protein_coding | tolerated(0.09) | possibly_damaging(0.513) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SLC35G1 | SNV | Missense_Mutation | c.673N>G | p.Thr225Ala | p.T225A | Q2M3R5 | protein_coding | tolerated(0.37) | benign(0.023) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
SLC35G1 | SNV | Missense_Mutation | rs770140554 | c.710C>T | p.Ser237Leu | p.S237L | Q2M3R5 | protein_coding | tolerated(0.83) | benign(0) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC35G1 | SNV | Missense_Mutation | c.743N>A | p.Ser248Tyr | p.S248Y | Q2M3R5 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC35G1 | SNV | Missense_Mutation | rs752900485 | c.389N>A | p.Arg130Gln | p.R130Q | Q2M3R5 | protein_coding | deleterious(0) | possibly_damaging(0.844) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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