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Gene: SHISA4 |
Gene summary for SHISA4 |
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Gene information | Species | Human | Gene symbol | SHISA4 | Gene ID | 149345 |
Gene name | shisa family member 4 | |
Gene Alias | C1orf40 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96DD7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
149345 | SHISA4 | P39T-E | Human | Esophagus | ESCC | 3.75e-02 | 1.50e-01 | 0.0894 |
149345 | SHISA4 | P40T-E | Human | Esophagus | ESCC | 5.71e-04 | 1.28e-01 | 0.109 |
149345 | SHISA4 | P42T-E | Human | Esophagus | ESCC | 7.83e-06 | 2.74e-01 | 0.1175 |
149345 | SHISA4 | P44T-E | Human | Esophagus | ESCC | 5.73e-13 | 3.87e-01 | 0.1096 |
149345 | SHISA4 | P47T-E | Human | Esophagus | ESCC | 8.97e-21 | 5.31e-01 | 0.1067 |
149345 | SHISA4 | P48T-E | Human | Esophagus | ESCC | 3.47e-08 | 9.76e-02 | 0.0959 |
149345 | SHISA4 | P49T-E | Human | Esophagus | ESCC | 1.04e-14 | 9.37e-01 | 0.1768 |
149345 | SHISA4 | P52T-E | Human | Esophagus | ESCC | 8.92e-12 | 3.22e-01 | 0.1555 |
149345 | SHISA4 | P56T-E | Human | Esophagus | ESCC | 5.12e-14 | 1.29e+00 | 0.1613 |
149345 | SHISA4 | P57T-E | Human | Esophagus | ESCC | 3.85e-08 | 2.37e-01 | 0.0926 |
149345 | SHISA4 | P61T-E | Human | Esophagus | ESCC | 2.26e-10 | 3.13e-01 | 0.099 |
149345 | SHISA4 | P62T-E | Human | Esophagus | ESCC | 4.44e-08 | 1.97e-01 | 0.1302 |
149345 | SHISA4 | P65T-E | Human | Esophagus | ESCC | 1.41e-08 | 1.66e-01 | 0.0978 |
149345 | SHISA4 | P74T-E | Human | Esophagus | ESCC | 1.21e-24 | 5.91e-01 | 0.1479 |
149345 | SHISA4 | P75T-E | Human | Esophagus | ESCC | 1.02e-15 | 3.56e-01 | 0.1125 |
149345 | SHISA4 | P76T-E | Human | Esophagus | ESCC | 6.43e-38 | 6.33e-01 | 0.1207 |
149345 | SHISA4 | P79T-E | Human | Esophagus | ESCC | 1.66e-21 | 4.14e-01 | 0.1154 |
149345 | SHISA4 | P80T-E | Human | Esophagus | ESCC | 3.01e-09 | 2.48e-01 | 0.155 |
149345 | SHISA4 | P82T-E | Human | Esophagus | ESCC | 4.72e-09 | 4.78e-01 | 0.1072 |
149345 | SHISA4 | P89T-E | Human | Esophagus | ESCC | 8.44e-12 | 8.51e-01 | 0.1752 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SHISA4 | SNV | Missense_Mutation | rs867436400 | c.268N>A | p.Ala90Thr | p.A90T | Q96DD7 | protein_coding | deleterious(0) | possibly_damaging(0.7) | TCGA-D8-A1Y2-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
SHISA4 | deletion | In_Frame_Del | novel | c.168_182delNNNNNNNNNNNNNNN | p.Tyr58_Cys62del | p.Y58_C62del | Q96DD7 | protein_coding | TCGA-A7-A4SE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | ||
SHISA4 | insertion | Frame_Shift_Ins | novel | c.436_437insCA | p.Asp146AlafsTer65 | p.D146Afs*65 | Q96DD7 | protein_coding | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR | ||
SHISA4 | insertion | Frame_Shift_Ins | novel | c.438_439insTTTCTGGGGCAGGAGCCTAT | p.Pro147PhefsTer70 | p.P147Ffs*70 | Q96DD7 | protein_coding | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR | ||
SHISA4 | SNV | Missense_Mutation | rs367890261 | c.347G>A | p.Arg116His | p.R116H | Q96DD7 | protein_coding | deleterious(0.01) | probably_damaging(0.961) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SHISA4 | SNV | Missense_Mutation | novel | c.145T>G | p.Phe49Val | p.F49V | Q96DD7 | protein_coding | tolerated(0.32) | benign(0.007) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SHISA4 | SNV | Missense_Mutation | c.40G>A | p.Ala14Thr | p.A14T | Q96DD7 | protein_coding | tolerated_low_confidence(0.15) | benign(0.003) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SHISA4 | SNV | Missense_Mutation | novel | c.89A>T | p.Asp30Val | p.D30V | Q96DD7 | protein_coding | deleterious(0) | benign(0.44) | TCGA-AG-3894-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
SHISA4 | SNV | Missense_Mutation | novel | c.370N>A | p.Pro124Thr | p.P124T | Q96DD7 | protein_coding | tolerated(0.08) | benign(0.007) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SHISA4 | SNV | Missense_Mutation | novel | c.569N>T | p.Pro190Leu | p.P190L | Q96DD7 | protein_coding | tolerated(0.74) | benign(0.098) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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