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Gene: SERP1 |
Gene summary for SERP1 |
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Gene information | Species | Human | Gene symbol | SERP1 | Gene ID | 27230 |
Gene name | stress associated endoplasmic reticulum protein 1 | |
Gene Alias | RAMP4 | |
Cytomap | 3q25.1 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q9Y6X1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27230 | SERP1 | GSM4909319 | Human | Breast | IDC | 4.01e-68 | -5.34e-01 | 0.1563 |
27230 | SERP1 | GSM4909320 | Human | Breast | IDC | 1.07e-10 | -4.72e-01 | 0.1575 |
27230 | SERP1 | GSM4909321 | Human | Breast | IDC | 5.09e-18 | -1.54e-01 | 0.1559 |
27230 | SERP1 | brca2 | Human | Breast | Precancer | 4.13e-02 | -3.65e-02 | -0.024 |
27230 | SERP1 | brca3 | Human | Breast | Precancer | 1.74e-02 | 5.79e-02 | -0.0263 |
27230 | SERP1 | M2 | Human | Breast | IDC | 1.84e-23 | 5.53e-01 | 0.21 |
27230 | SERP1 | NCCBC14 | Human | Breast | DCIS | 2.35e-22 | -2.16e-01 | 0.2021 |
27230 | SERP1 | NCCBC2 | Human | Breast | DCIS | 4.37e-04 | -2.65e-01 | 0.1554 |
27230 | SERP1 | NCCBC3 | Human | Breast | DCIS | 1.08e-02 | -2.14e-01 | 0.1198 |
27230 | SERP1 | NCCBC5 | Human | Breast | DCIS | 1.64e-27 | -3.79e-01 | 0.2046 |
27230 | SERP1 | NCCBC6 | Human | Breast | DCIS | 1.87e-02 | 2.44e-01 | 0.2095 |
27230 | SERP1 | P1 | Human | Breast | IDC | 2.53e-38 | -5.74e-01 | 0.1527 |
27230 | SERP1 | P2 | Human | Breast | IDC | 1.04e-50 | 5.88e-01 | 0.21 |
27230 | SERP1 | DCIS2 | Human | Breast | DCIS | 2.40e-31 | 5.68e-02 | 0.0085 |
27230 | SERP1 | CA_HPV_1 | Human | Cervix | CC | 9.57e-10 | -1.10e-01 | 0.0264 |
27230 | SERP1 | CA_HPV_3 | Human | Cervix | CC | 1.65e-06 | -1.87e-01 | 0.0414 |
27230 | SERP1 | CCI_1 | Human | Cervix | CC | 7.87e-08 | -6.81e-01 | 0.528 |
27230 | SERP1 | CCI_3 | Human | Cervix | CC | 1.38e-06 | -3.97e-01 | 0.516 |
27230 | SERP1 | CCII_1 | Human | Cervix | CC | 1.10e-39 | -1.09e+00 | 0.3249 |
27230 | SERP1 | sample3 | Human | Cervix | CC | 9.29e-04 | 5.04e-02 | 0.1387 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064179 | Breast | Precancer | regulation of translation | 67/1080 | 468/18723 | 4.71e-12 | 7.64e-10 | 67 |
GO:00457279 | Breast | Precancer | positive regulation of translation | 32/1080 | 136/18723 | 5.89e-12 | 9.27e-10 | 32 |
GO:00342509 | Breast | Precancer | positive regulation of cellular amide metabolic process | 33/1080 | 162/18723 | 1.72e-10 | 1.77e-08 | 33 |
GO:00069869 | Breast | Precancer | response to unfolded protein | 28/1080 | 137/18723 | 3.81e-09 | 3.00e-07 | 28 |
GO:00359669 | Breast | Precancer | response to topologically incorrect protein | 29/1080 | 159/18723 | 3.00e-08 | 1.89e-06 | 29 |
GO:00349769 | Breast | Precancer | response to endoplasmic reticulum stress | 38/1080 | 256/18723 | 7.89e-08 | 4.60e-06 | 38 |
GO:00346209 | Breast | Precancer | cellular response to unfolded protein | 21/1080 | 96/18723 | 9.80e-08 | 5.46e-06 | 21 |
GO:00359679 | Breast | Precancer | cellular response to topologically incorrect protein | 22/1080 | 116/18723 | 6.84e-07 | 2.80e-05 | 22 |
GO:00075688 | Breast | Precancer | aging | 41/1080 | 339/18723 | 5.95e-06 | 1.71e-04 | 41 |
GO:00309687 | Breast | Precancer | endoplasmic reticulum unfolded protein response | 15/1080 | 74/18723 | 1.74e-05 | 4.17e-04 | 15 |
GO:19049519 | Breast | Precancer | positive regulation of establishment of protein localization | 36/1080 | 319/18723 | 9.30e-05 | 1.75e-03 | 36 |
GO:00060066 | Breast | Precancer | glucose metabolic process | 23/1080 | 196/18723 | 9.54e-04 | 1.07e-02 | 23 |
GO:00512229 | Breast | Precancer | positive regulation of protein transport | 31/1080 | 303/18723 | 1.44e-03 | 1.50e-02 | 31 |
GO:00507086 | Breast | Precancer | regulation of protein secretion | 28/1080 | 268/18723 | 1.76e-03 | 1.74e-02 | 28 |
GO:00059966 | Breast | Precancer | monosaccharide metabolic process | 27/1080 | 257/18723 | 1.94e-03 | 1.88e-02 | 27 |
GO:00193186 | Breast | Precancer | hexose metabolic process | 25/1080 | 237/18723 | 2.64e-03 | 2.36e-02 | 25 |
GO:00158336 | Breast | Precancer | peptide transport | 27/1080 | 264/18723 | 2.84e-03 | 2.49e-02 | 27 |
GO:00900875 | Breast | Precancer | regulation of peptide transport | 22/1080 | 202/18723 | 3.14e-03 | 2.65e-02 | 22 |
GO:00300736 | Breast | Precancer | insulin secretion | 21/1080 | 195/18723 | 4.38e-03 | 3.42e-02 | 21 |
GO:00716926 | Breast | Precancer | protein localization to extracellular region | 34/1080 | 368/18723 | 4.65e-03 | 3.58e-02 | 34 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SERP1 | SNV | Missense_Mutation | c.194N>T | p.Gly65Val | p.G65V | Q9Y6X1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SERP1 | SNV | Missense_Mutation | c.86G>T | p.Arg29Ile | p.R29I | Q9Y6X1 | protein_coding | deleterious(0.03) | benign(0.017) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SERP1 | SNV | Missense_Mutation | novel | c.130N>A | p.Ala44Thr | p.A44T | Q9Y6X1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SERP1 | SNV | Missense_Mutation | novel | c.50N>G | p.Asn17Ser | p.N17S | Q9Y6X1 | protein_coding | deleterious(0.03) | possibly_damaging(0.484) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
SERP1 | SNV | Missense_Mutation | novel | c.143N>C | p.Phe48Ser | p.F48S | Q9Y6X1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SERP1 | SNV | Missense_Mutation | novel | c.163N>G | p.Ile55Val | p.I55V | Q9Y6X1 | protein_coding | tolerated(0.54) | benign(0.011) | TCGA-DD-AAE7-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SERP1 | SNV | Missense_Mutation | c.39G>T | p.Lys13Asn | p.K13N | Q9Y6X1 | protein_coding | deleterious(0.01) | probably_damaging(0.911) | TCGA-85-6560-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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