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Gene: SEPTIN11 |
Gene summary for SEPTIN11 |
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Gene information | Species | Human | Gene symbol | SEPTIN11 | Gene ID | 55752 |
Gene name | septin 11 | |
Gene Alias | SEPT11 | |
Cytomap | 4q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000910 | UniProtAcc | Q9NVA2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55752 | SEPTIN11 | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.37e-05 | 2.47e-01 | 0.0528 |
55752 | SEPTIN11 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.58e-09 | 4.99e-01 | 0.0131 |
55752 | SEPTIN11 | HTA11_10623_2000001011 | Human | Colorectum | AD | 5.57e-13 | 5.01e-01 | -0.0177 |
55752 | SEPTIN11 | HTA11_6801_2000001011 | Human | Colorectum | SER | 4.31e-12 | 5.47e-01 | 0.0171 |
55752 | SEPTIN11 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.62e-09 | 3.20e-01 | 0.0338 |
55752 | SEPTIN11 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.44e-33 | 5.85e-01 | 0.0674 |
55752 | SEPTIN11 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.86e-09 | 4.73e-01 | 0.0112 |
55752 | SEPTIN11 | HTA11_7469_2000001011 | Human | Colorectum | AD | 2.39e-03 | 4.15e-01 | -0.0124 |
55752 | SEPTIN11 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.62e-08 | 2.88e-01 | 0.0588 |
55752 | SEPTIN11 | AEH-subject1 | Human | Endometrium | AEH | 7.69e-12 | 2.61e-01 | -0.3059 |
55752 | SEPTIN11 | AEH-subject2 | Human | Endometrium | AEH | 1.65e-11 | 2.83e-01 | -0.2525 |
55752 | SEPTIN11 | AEH-subject3 | Human | Endometrium | AEH | 3.72e-11 | 2.63e-01 | -0.2576 |
55752 | SEPTIN11 | AEH-subject4 | Human | Endometrium | AEH | 9.03e-21 | 4.98e-01 | -0.2657 |
55752 | SEPTIN11 | AEH-subject5 | Human | Endometrium | AEH | 1.31e-19 | 3.65e-01 | -0.2953 |
55752 | SEPTIN11 | EEC-subject1 | Human | Endometrium | EEC | 8.70e-09 | 2.30e-01 | -0.2682 |
55752 | SEPTIN11 | EEC-subject2 | Human | Endometrium | EEC | 3.99e-06 | 1.85e-01 | -0.2607 |
55752 | SEPTIN11 | EEC-subject3 | Human | Endometrium | EEC | 3.51e-03 | 1.79e-01 | -0.2525 |
55752 | SEPTIN11 | EEC-subject4 | Human | Endometrium | EEC | 8.15e-11 | 2.71e-01 | -0.2571 |
55752 | SEPTIN11 | EEC-subject5 | Human | Endometrium | EEC | 1.88e-08 | 1.89e-01 | -0.249 |
55752 | SEPTIN11 | LZE2T | Human | Esophagus | ESCC | 3.94e-07 | 9.65e-01 | 0.082 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0000910 | Colorectum | AD | cytokinesis | 59/3918 | 173/18723 | 3.74e-05 | 6.75e-04 | 59 |
GO:0061640 | Colorectum | AD | cytoskeleton-dependent cytokinesis | 37/3918 | 100/18723 | 1.58e-04 | 2.20e-03 | 37 |
GO:0050808 | Colorectum | AD | synapse organization | 112/3918 | 426/18723 | 4.25e-03 | 2.92e-02 | 112 |
GO:0050807 | Colorectum | AD | regulation of synapse organization | 60/3918 | 211/18723 | 5.67e-03 | 3.64e-02 | 60 |
GO:00009101 | Colorectum | SER | cytokinesis | 45/2897 | 173/18723 | 2.28e-04 | 3.93e-03 | 45 |
GO:00616401 | Colorectum | SER | cytoskeleton-dependent cytokinesis | 29/2897 | 100/18723 | 4.25e-04 | 6.25e-03 | 29 |
GO:00508081 | Colorectum | SER | synapse organization | 85/2897 | 426/18723 | 7.17e-03 | 4.99e-02 | 85 |
GO:00009108 | Endometrium | AEH | cytokinesis | 40/2100 | 173/18723 | 6.01e-06 | 1.49e-04 | 40 |
GO:00616403 | Endometrium | AEH | cytoskeleton-dependent cytokinesis | 24/2100 | 100/18723 | 2.27e-04 | 2.75e-03 | 24 |
GO:00508086 | Endometrium | AEH | synapse organization | 67/2100 | 426/18723 | 2.67e-03 | 1.94e-02 | 67 |
GO:000091013 | Endometrium | EEC | cytokinesis | 40/2168 | 173/18723 | 1.29e-05 | 2.60e-04 | 40 |
GO:006164012 | Endometrium | EEC | cytoskeleton-dependent cytokinesis | 24/2168 | 100/18723 | 3.66e-04 | 3.95e-03 | 24 |
GO:005080812 | Endometrium | EEC | synapse organization | 68/2168 | 426/18723 | 3.73e-03 | 2.49e-02 | 68 |
GO:000091016 | Esophagus | ESCC | cytokinesis | 115/8552 | 173/18723 | 2.48e-08 | 4.68e-07 | 115 |
GO:006164015 | Esophagus | ESCC | cytoskeleton-dependent cytokinesis | 72/8552 | 100/18723 | 8.10e-08 | 1.39e-06 | 72 |
GO:00508085 | Lung | IAC | synapse organization | 65/2061 | 426/18723 | 4.05e-03 | 3.31e-02 | 65 |
GO:00009106 | Lung | IAC | cytokinesis | 31/2061 | 173/18723 | 4.28e-03 | 3.41e-02 | 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa05100 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051001 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa051002 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
hsa051313 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
hsa051003 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
hsa0513126 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa0510026 | Endometrium | AEH | Bacterial invasion of epithelial cells | 32/1197 | 77/8465 | 3.28e-09 | 5.91e-08 | 4.33e-08 | 32 |
hsa05131111 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa05100111 | Endometrium | AEH | Bacterial invasion of epithelial cells | 32/1197 | 77/8465 | 3.28e-09 | 5.91e-08 | 4.33e-08 | 32 |
hsa0513127 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
hsa0510027 | Endometrium | EEC | Bacterial invasion of epithelial cells | 30/1237 | 77/8465 | 1.26e-07 | 1.88e-06 | 1.40e-06 | 30 |
hsa0513136 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
hsa0510036 | Endometrium | EEC | Bacterial invasion of epithelial cells | 30/1237 | 77/8465 | 1.26e-07 | 1.88e-06 | 1.40e-06 | 30 |
hsa05131211 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa05100211 | Esophagus | ESCC | Bacterial invasion of epithelial cells | 59/4205 | 77/8465 | 1.05e-06 | 6.76e-06 | 3.46e-06 | 59 |
hsa05131310 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa05100310 | Esophagus | ESCC | Bacterial invasion of epithelial cells | 59/4205 | 77/8465 | 1.05e-06 | 6.76e-06 | 3.46e-06 | 59 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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