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Gene: SEMA4C |
Gene summary for SEMA4C |
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Gene information | Species | Human | Gene symbol | SEMA4C | Gene ID | 54910 |
Gene name | semaphorin 4C | |
Gene Alias | M-SEMA-F | |
Cytomap | 2q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q9C0C4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54910 | SEMA4C | P36T-E | Human | Esophagus | ESCC | 2.07e-02 | 4.72e-02 | 0.1187 |
54910 | SEMA4C | P37T-E | Human | Esophagus | ESCC | 1.28e-05 | 4.26e-02 | 0.1371 |
54910 | SEMA4C | P42T-E | Human | Esophagus | ESCC | 1.14e-11 | 2.95e-01 | 0.1175 |
54910 | SEMA4C | P47T-E | Human | Esophagus | ESCC | 9.64e-12 | 1.77e-01 | 0.1067 |
54910 | SEMA4C | P48T-E | Human | Esophagus | ESCC | 3.21e-07 | 2.29e-01 | 0.0959 |
54910 | SEMA4C | P49T-E | Human | Esophagus | ESCC | 4.00e-06 | 5.57e-01 | 0.1768 |
54910 | SEMA4C | P52T-E | Human | Esophagus | ESCC | 2.88e-10 | 9.33e-02 | 0.1555 |
54910 | SEMA4C | P54T-E | Human | Esophagus | ESCC | 3.41e-15 | 3.37e-01 | 0.0975 |
54910 | SEMA4C | P56T-E | Human | Esophagus | ESCC | 3.44e-03 | 6.13e-01 | 0.1613 |
54910 | SEMA4C | P57T-E | Human | Esophagus | ESCC | 1.88e-07 | 1.69e-01 | 0.0926 |
54910 | SEMA4C | P61T-E | Human | Esophagus | ESCC | 1.40e-11 | 1.47e-01 | 0.099 |
54910 | SEMA4C | P62T-E | Human | Esophagus | ESCC | 3.46e-10 | 2.64e-01 | 0.1302 |
54910 | SEMA4C | P65T-E | Human | Esophagus | ESCC | 6.45e-11 | 1.22e-01 | 0.0978 |
54910 | SEMA4C | P74T-E | Human | Esophagus | ESCC | 1.67e-09 | 2.75e-01 | 0.1479 |
54910 | SEMA4C | P75T-E | Human | Esophagus | ESCC | 4.23e-05 | 1.09e-01 | 0.1125 |
54910 | SEMA4C | P76T-E | Human | Esophagus | ESCC | 7.52e-07 | 3.04e-02 | 0.1207 |
54910 | SEMA4C | P79T-E | Human | Esophagus | ESCC | 8.34e-03 | 1.27e-01 | 0.1154 |
54910 | SEMA4C | P80T-E | Human | Esophagus | ESCC | 2.27e-04 | 1.90e-01 | 0.155 |
54910 | SEMA4C | P83T-E | Human | Esophagus | ESCC | 7.34e-11 | 2.42e-01 | 0.1738 |
54910 | SEMA4C | P128T-E | Human | Esophagus | ESCC | 1.62e-03 | 4.38e-02 | 0.1241 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
GO:000184115 | Esophagus | ESCC | neural tube formation | 75/8552 | 102/18723 | 9.68e-09 | 1.95e-07 | 75 |
GO:000184314 | Esophagus | ESCC | neural tube closure | 66/8552 | 88/18723 | 1.98e-08 | 3.82e-07 | 66 |
GO:001402014 | Esophagus | ESCC | primary neural tube formation | 69/8552 | 94/18723 | 4.22e-08 | 7.76e-07 | 69 |
GO:006060614 | Esophagus | ESCC | tube closure | 66/8552 | 89/18723 | 4.24e-08 | 7.76e-07 | 66 |
GO:003253520 | Esophagus | ESCC | regulation of cellular component size | 227/8552 | 383/18723 | 4.77e-08 | 8.60e-07 | 227 |
GO:003109818 | Esophagus | ESCC | stress-activated protein kinase signaling cascade | 154/8552 | 247/18723 | 8.53e-08 | 1.44e-06 | 154 |
GO:00219159 | Esophagus | ESCC | neural tube development | 101/8552 | 152/18723 | 1.78e-07 | 2.79e-06 | 101 |
GO:00163316 | Esophagus | ESCC | morphogenesis of embryonic epithelium | 98/8552 | 147/18723 | 2.12e-07 | 3.27e-06 | 98 |
GO:000183814 | Esophagus | ESCC | embryonic epithelial tube formation | 83/8552 | 121/18723 | 2.78e-07 | 4.08e-06 | 83 |
GO:005140318 | Esophagus | ESCC | stress-activated MAPK cascade | 147/8552 | 239/18723 | 5.43e-07 | 7.18e-06 | 147 |
GO:003514815 | Esophagus | ESCC | tube formation | 96/8552 | 148/18723 | 1.86e-06 | 2.16e-05 | 96 |
GO:00721759 | Esophagus | ESCC | epithelial tube formation | 86/8552 | 132/18723 | 4.81e-06 | 5.10e-05 | 86 |
GO:00459267 | Esophagus | ESCC | negative regulation of growth | 148/8552 | 249/18723 | 7.88e-06 | 7.73e-05 | 148 |
GO:006056210 | Esophagus | ESCC | epithelial tube morphogenesis | 187/8552 | 325/18723 | 9.95e-06 | 9.44e-05 | 187 |
GO:007030217 | Esophagus | ESCC | regulation of stress-activated protein kinase signaling cascade | 119/8552 | 195/18723 | 1.07e-05 | 1.01e-04 | 119 |
GO:003287217 | Esophagus | ESCC | regulation of stress-activated MAPK cascade | 116/8552 | 192/18723 | 2.63e-05 | 2.21e-04 | 116 |
GO:00488638 | Esophagus | ESCC | stem cell differentiation | 122/8552 | 206/18723 | 5.95e-05 | 4.59e-04 | 122 |
GO:005076710 | Esophagus | ESCC | regulation of neurogenesis | 203/8552 | 364/18723 | 6.10e-05 | 4.68e-04 | 203 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0436016 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0436017 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0436014 | Oral cavity | OSCC | Axon guidance | 97/3704 | 182/8465 | 5.59e-03 | 1.33e-02 | 6.76e-03 | 97 |
hsa0436015 | Oral cavity | OSCC | Axon guidance | 97/3704 | 182/8465 | 5.59e-03 | 1.33e-02 | 6.76e-03 | 97 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
SEMA4C | PLXNB2 | SEMA4C_PLXNB2 | SEMA4 | CRC | MSI-H |
SEMA4C | PLXNB2 | SEMA4C_PLXNB2 | SEMA4 | CRC | MSS |
SEMA4C | PLXNB2 | SEMA4C_PLXNB2 | SEMA4 | Endometrium | AEH |
SEMA4C | PLXNB2 | SEMA4C_PLXNB2 | SEMA4 | Endometrium | Healthy |
SEMA4C | PLXNB2 | SEMA4C_PLXNB2 | SEMA4 | HNSCC | Precancer |
SEMA4C | PLXNB2 | SEMA4C_PLXNB2 | SEMA4 | Liver | Healthy |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEMA4C | SNV | Missense_Mutation | c.295T>C | p.Cys99Arg | p.C99R | Q9C0C4 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-A7-A26G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
SEMA4C | SNV | Missense_Mutation | novel | c.1008G>T | p.Glu336Asp | p.E336D | Q9C0C4 | protein_coding | tolerated(1) | benign(0.006) | TCGA-AC-A62V-01 | Breast | breast invasive carcinoma | Male | <65 | III/IV | Targeted Molecular therapy | denosumab | PD |
SEMA4C | SNV | Missense_Mutation | c.1555N>C | p.Trp519Arg | p.W519R | Q9C0C4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
SEMA4C | SNV | Missense_Mutation | novel | c.113N>C | p.Leu38Pro | p.L38P | Q9C0C4 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-BH-A0E2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
SEMA4C | SNV | Missense_Mutation | novel | c.830C>T | p.Thr277Met | p.T277M | Q9C0C4 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-D8-A3Z6-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphane | SD |
SEMA4C | insertion | Nonsense_Mutation | novel | c.2292_2293insCTGGGTCCTCCTGGTGAGTCATTGGAGCTATGAAGG | p.Gly764_Ile765insLeuGlyProProGlyGluSerLeuGluLeuTerArg | p.G764_I765insLGPPGESLEL*R | Q9C0C4 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
SEMA4C | insertion | Frame_Shift_Ins | novel | c.113_114insA | p.Ala39GlyfsTer60 | p.A39Gfs*60 | Q9C0C4 | protein_coding | TCGA-BH-A0E2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | ||
SEMA4C | SNV | Missense_Mutation | c.2059C>T | p.Arg687Cys | p.R687C | Q9C0C4 | protein_coding | tolerated(0.14) | possibly_damaging(0.877) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SEMA4C | SNV | Missense_Mutation | c.172N>G | p.Leu58Val | p.L58V | Q9C0C4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | |
SEMA4C | SNV | Missense_Mutation | rs780410537 | c.104N>T | p.Ser35Phe | p.S35F | Q9C0C4 | protein_coding | tolerated(0.45) | benign(0.003) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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