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Gene: SEL1L3 |
Gene summary for SEL1L3 |
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Gene information | Species | Human | Gene symbol | SEL1L3 | Gene ID | 23231 |
Gene name | SEL1L family member 3 | |
Gene Alias | Sel-1L3 | |
Cytomap | 4p15.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q68CR1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23231 | SEL1L3 | A015-C-104 | Human | Colorectum | FAP | 3.12e-26 | -3.03e-01 | -0.1899 |
23231 | SEL1L3 | A001-C-014 | Human | Colorectum | FAP | 2.24e-13 | -9.62e-02 | 0.0135 |
23231 | SEL1L3 | A002-C-016 | Human | Colorectum | FAP | 3.21e-17 | -2.02e-01 | 0.0521 |
23231 | SEL1L3 | A015-C-002 | Human | Colorectum | FAP | 1.06e-09 | -2.27e-01 | -0.0763 |
23231 | SEL1L3 | A001-C-203 | Human | Colorectum | FAP | 9.55e-07 | 2.57e-02 | -0.0481 |
23231 | SEL1L3 | A002-C-116 | Human | Colorectum | FAP | 2.47e-27 | -2.84e-01 | -0.0452 |
23231 | SEL1L3 | A014-C-008 | Human | Colorectum | FAP | 4.74e-14 | -3.94e-01 | -0.191 |
23231 | SEL1L3 | A018-E-020 | Human | Colorectum | FAP | 2.19e-16 | -2.47e-01 | -0.2034 |
23231 | SEL1L3 | F034 | Human | Colorectum | FAP | 4.09e-14 | -2.27e-01 | -0.0665 |
23231 | SEL1L3 | F072B | Human | Colorectum | FAP | 3.20e-06 | 2.93e-01 | 0.257 |
23231 | SEL1L3 | CRC-1-8810 | Human | Colorectum | CRC | 4.43e-04 | -4.84e-02 | 0.6257 |
23231 | SEL1L3 | CRC-3-11773 | Human | Colorectum | CRC | 5.00e-08 | 1.59e-01 | 0.2564 |
23231 | SEL1L3 | LZE24T | Human | Esophagus | ESCC | 1.44e-02 | 1.21e-01 | 0.0596 |
23231 | SEL1L3 | P4T-E | Human | Esophagus | ESCC | 2.16e-03 | 1.05e-01 | 0.1323 |
23231 | SEL1L3 | P5T-E | Human | Esophagus | ESCC | 4.69e-15 | 8.75e-02 | 0.1327 |
23231 | SEL1L3 | P8T-E | Human | Esophagus | ESCC | 8.54e-27 | 6.02e-01 | 0.0889 |
23231 | SEL1L3 | P9T-E | Human | Esophagus | ESCC | 1.21e-07 | 1.04e-01 | 0.1131 |
23231 | SEL1L3 | P10T-E | Human | Esophagus | ESCC | 4.29e-03 | -5.33e-03 | 0.116 |
23231 | SEL1L3 | P11T-E | Human | Esophagus | ESCC | 3.60e-03 | 1.15e-01 | 0.1426 |
23231 | SEL1L3 | P12T-E | Human | Esophagus | ESCC | 9.54e-17 | 1.33e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEL1L3 | SNV | Missense_Mutation | c.1696N>A | p.Cys566Ser | p.C566S | Q68CR1 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A2-A25F-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | |
SEL1L3 | SNV | Missense_Mutation | rs373688085 | c.698N>A | p.Arg233Gln | p.R233Q | Q68CR1 | protein_coding | tolerated(0.6) | benign(0.003) | TCGA-A8-A08B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
SEL1L3 | SNV | Missense_Mutation | c.1131N>C | p.Leu377Phe | p.L377F | Q68CR1 | protein_coding | tolerated(0.14) | probably_damaging(0.965) | TCGA-A8-A09X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SEL1L3 | SNV | Missense_Mutation | c.2574N>C | p.Glu858Asp | p.E858D | Q68CR1 | protein_coding | deleterious(0.03) | benign(0.263) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SEL1L3 | SNV | Missense_Mutation | c.2262N>A | p.Met754Ile | p.M754I | Q68CR1 | protein_coding | deleterious(0.01) | possibly_damaging(0.843) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD | |
SEL1L3 | SNV | Missense_Mutation | c.806N>T | p.Arg269Met | p.R269M | Q68CR1 | protein_coding | deleterious(0.05) | benign(0.312) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SEL1L3 | SNV | Missense_Mutation | novel | c.2146N>C | p.Trp716Arg | p.W716R | Q68CR1 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
SEL1L3 | SNV | Missense_Mutation | novel | c.2716N>C | p.Glu906Gln | p.E906Q | Q68CR1 | protein_coding | tolerated(0.07) | probably_damaging(0.972) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SEL1L3 | SNV | Missense_Mutation | novel | c.1240T>G | p.Phe414Val | p.F414V | Q68CR1 | protein_coding | deleterious(0) | possibly_damaging(0.776) | TCGA-BH-A1FH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
SEL1L3 | SNV | Missense_Mutation | c.1654C>T | p.His552Tyr | p.H552Y | Q68CR1 | protein_coding | tolerated(0.11) | benign(0.081) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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