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Gene: SCFD1 |
Gene summary for SCFD1 |
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Gene information | Species | Human | Gene symbol | SCFD1 | Gene ID | 23256 |
Gene name | sec1 family domain containing 1 | |
Gene Alias | C14orf163 | |
Cytomap | 14q12 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q8WVM8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23256 | SCFD1 | P12T-E | Human | Esophagus | ESCC | 1.75e-47 | 9.61e-01 | 0.1122 |
23256 | SCFD1 | P15T-E | Human | Esophagus | ESCC | 3.98e-40 | 7.83e-01 | 0.1149 |
23256 | SCFD1 | P16T-E | Human | Esophagus | ESCC | 1.18e-17 | 2.59e-01 | 0.1153 |
23256 | SCFD1 | P17T-E | Human | Esophagus | ESCC | 1.70e-07 | 3.22e-01 | 0.1278 |
23256 | SCFD1 | P19T-E | Human | Esophagus | ESCC | 7.32e-13 | 5.39e-01 | 0.1662 |
23256 | SCFD1 | P20T-E | Human | Esophagus | ESCC | 2.95e-23 | 2.87e-01 | 0.1124 |
23256 | SCFD1 | P21T-E | Human | Esophagus | ESCC | 3.87e-18 | 3.15e-01 | 0.1617 |
23256 | SCFD1 | P22T-E | Human | Esophagus | ESCC | 2.75e-17 | 1.11e-01 | 0.1236 |
23256 | SCFD1 | P23T-E | Human | Esophagus | ESCC | 1.76e-25 | 5.74e-01 | 0.108 |
23256 | SCFD1 | P24T-E | Human | Esophagus | ESCC | 1.19e-18 | 5.15e-01 | 0.1287 |
23256 | SCFD1 | P26T-E | Human | Esophagus | ESCC | 2.12e-27 | 4.92e-01 | 0.1276 |
23256 | SCFD1 | P27T-E | Human | Esophagus | ESCC | 2.96e-28 | 6.19e-01 | 0.1055 |
23256 | SCFD1 | P28T-E | Human | Esophagus | ESCC | 5.71e-12 | 1.15e-01 | 0.1149 |
23256 | SCFD1 | P30T-E | Human | Esophagus | ESCC | 1.27e-25 | 8.26e-01 | 0.137 |
23256 | SCFD1 | P31T-E | Human | Esophagus | ESCC | 2.62e-30 | 5.39e-01 | 0.1251 |
23256 | SCFD1 | P32T-E | Human | Esophagus | ESCC | 3.16e-26 | 4.32e-01 | 0.1666 |
23256 | SCFD1 | P36T-E | Human | Esophagus | ESCC | 2.38e-15 | 4.47e-01 | 0.1187 |
23256 | SCFD1 | P37T-E | Human | Esophagus | ESCC | 3.54e-28 | 5.84e-01 | 0.1371 |
23256 | SCFD1 | P38T-E | Human | Esophagus | ESCC | 6.11e-14 | 3.75e-01 | 0.127 |
23256 | SCFD1 | P39T-E | Human | Esophagus | ESCC | 4.62e-15 | 1.60e-01 | 0.0894 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003133010 | Cervix | CC | negative regulation of cellular catabolic process | 63/2311 | 262/18723 | 1.10e-07 | 5.68e-06 | 63 |
GO:000989510 | Cervix | CC | negative regulation of catabolic process | 69/2311 | 320/18723 | 2.15e-06 | 6.55e-05 | 69 |
GO:00323868 | Cervix | CC | regulation of intracellular transport | 71/2311 | 337/18723 | 3.70e-06 | 9.74e-05 | 71 |
GO:00068927 | Cervix | CC | post-Golgi vesicle-mediated transport | 28/2311 | 104/18723 | 4.31e-05 | 6.61e-04 | 28 |
GO:00106399 | Cervix | CC | negative regulation of organelle organization | 68/2311 | 348/18723 | 7.40e-05 | 1.03e-03 | 68 |
GO:000166610 | Cervix | CC | response to hypoxia | 61/2311 | 307/18723 | 1.04e-04 | 1.34e-03 | 61 |
GO:007048210 | Cervix | CC | response to oxygen levels | 67/2311 | 347/18723 | 1.21e-04 | 1.51e-03 | 67 |
GO:00162367 | Cervix | CC | macroautophagy | 58/2311 | 291/18723 | 1.40e-04 | 1.70e-03 | 58 |
GO:00481938 | Cervix | CC | Golgi vesicle transport | 58/2311 | 296/18723 | 2.24e-04 | 2.54e-03 | 58 |
GO:003629310 | Cervix | CC | response to decreased oxygen levels | 62/2311 | 322/18723 | 2.29e-04 | 2.57e-03 | 62 |
GO:00105067 | Cervix | CC | regulation of autophagy | 61/2311 | 317/18723 | 2.61e-04 | 2.87e-03 | 61 |
GO:19021153 | Cervix | CC | regulation of organelle assembly | 40/2311 | 186/18723 | 2.92e-04 | 3.15e-03 | 40 |
GO:00096369 | Cervix | CC | response to toxic substance | 52/2311 | 262/18723 | 3.34e-04 | 3.52e-03 | 52 |
GO:00068907 | Cervix | CC | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 15/2311 | 52/18723 | 1.15e-03 | 9.39e-03 | 15 |
GO:00000452 | Cervix | CC | autophagosome assembly | 21/2311 | 99/18723 | 8.67e-03 | 4.46e-02 | 21 |
GO:004819317 | Esophagus | HGIN | Golgi vesicle transport | 83/2587 | 296/18723 | 8.59e-11 | 8.89e-09 | 83 |
GO:000989520 | Esophagus | HGIN | negative regulation of catabolic process | 87/2587 | 320/18723 | 1.74e-10 | 1.68e-08 | 87 |
GO:003133026 | Esophagus | HGIN | negative regulation of cellular catabolic process | 74/2587 | 262/18723 | 6.27e-10 | 5.30e-08 | 74 |
GO:001050616 | Esophagus | HGIN | regulation of autophagy | 84/2587 | 317/18723 | 1.39e-09 | 1.08e-07 | 84 |
GO:001623616 | Esophagus | HGIN | macroautophagy | 77/2587 | 291/18723 | 7.15e-09 | 4.61e-07 | 77 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCFD1 | SNV | Missense_Mutation | c.1193N>G | p.Leu398Arg | p.L398R | Q8WVM8 | protein_coding | deleterious(0) | benign(0.301) | TCGA-A8-A09X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SCFD1 | SNV | Missense_Mutation | c.673C>A | p.Leu225Ile | p.L225I | Q8WVM8 | protein_coding | deleterious(0.02) | possibly_damaging(0.811) | TCGA-BH-A0DK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
SCFD1 | SNV | Missense_Mutation | c.617C>T | p.Ala206Val | p.A206V | Q8WVM8 | protein_coding | tolerated(0.47) | benign(0.009) | TCGA-BH-A0EI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SCFD1 | SNV | Missense_Mutation | novel | c.34N>C | p.Ala12Pro | p.A12P | Q8WVM8 | protein_coding | tolerated(0.18) | possibly_damaging(0.665) | TCGA-BH-A18F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
SCFD1 | SNV | Missense_Mutation | c.1736N>C | p.Ser579Thr | p.S579T | Q8WVM8 | protein_coding | tolerated(0.45) | benign(0.056) | TCGA-E9-A1R4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
SCFD1 | SNV | Missense_Mutation | novel | c.730N>A | p.Asp244Asn | p.D244N | Q8WVM8 | protein_coding | tolerated(0.31) | possibly_damaging(0.528) | TCGA-E9-A2JT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
SCFD1 | SNV | Missense_Mutation | novel | c.57N>C | p.Gln19His | p.Q19H | Q8WVM8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-VS-A8EK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
SCFD1 | SNV | Missense_Mutation | c.1244C>A | p.Ala415Glu | p.A415E | Q8WVM8 | protein_coding | tolerated(1) | benign(0.011) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SCFD1 | SNV | Missense_Mutation | rs561696273 | c.320N>A | p.Arg107Gln | p.R107Q | Q8WVM8 | protein_coding | tolerated(0.7) | benign(0.022) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SCFD1 | SNV | Missense_Mutation | novel | c.829N>C | p.Tyr277His | p.Y277H | Q8WVM8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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