|
Gene: SARS1 |
Gene summary for SARS1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SARS1 | Gene ID | 6301 |
Gene name | seryl-tRNA synthetase 1 | |
Gene Alias | NEDMAS | |
Cytomap | 1p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q5T5C7 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6301 | SARS1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.03e-06 | 3.63e-01 | 0.0446 |
6301 | SARS1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 7.79e-04 | 2.70e-01 | 0.0451 |
6301 | SARS1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.95e-07 | 3.65e-01 | 0.0528 |
6301 | SARS1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.76e-08 | 4.31e-01 | 0.0131 |
6301 | SARS1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.79e-09 | 3.53e-01 | -0.0177 |
6301 | SARS1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.85e-04 | 3.00e-01 | 0.0171 |
6301 | SARS1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.30e-12 | 3.02e-01 | 0.0338 |
6301 | SARS1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.89e-27 | 4.86e-01 | 0.0674 |
6301 | SARS1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.41e-17 | 5.49e-01 | 0.0112 |
6301 | SARS1 | HTA11_7469_2000001011 | Human | Colorectum | AD | 2.51e-08 | 5.31e-01 | -0.0124 |
6301 | SARS1 | HTA11_11156_2000001011 | Human | Colorectum | AD | 2.46e-04 | 3.12e-01 | 0.0397 |
6301 | SARS1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.23e-19 | 5.09e-01 | 0.0588 |
Page: 1 2 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006418 | Colorectum | AD | tRNA aminoacylation for protein translation | 19/3918 | 41/18723 | 2.37e-04 | 3.03e-03 | 19 |
GO:0043039 | Colorectum | AD | tRNA aminoacylation | 19/3918 | 44/18723 | 7.13e-04 | 7.21e-03 | 19 |
GO:0043038 | Colorectum | AD | amino acid activation | 19/3918 | 45/18723 | 9.94e-04 | 9.28e-03 | 19 |
GO:0006520 | Colorectum | AD | cellular amino acid metabolic process | 81/3918 | 284/18723 | 1.37e-03 | 1.19e-02 | 81 |
GO:00064181 | Colorectum | SER | tRNA aminoacylation for protein translation | 17/2897 | 41/18723 | 5.75e-05 | 1.35e-03 | 17 |
GO:00430391 | Colorectum | SER | tRNA aminoacylation | 17/2897 | 44/18723 | 1.64e-04 | 3.12e-03 | 17 |
GO:00430381 | Colorectum | SER | amino acid activation | 17/2897 | 45/18723 | 2.25e-04 | 3.91e-03 | 17 |
GO:00065201 | Colorectum | SER | cellular amino acid metabolic process | 61/2897 | 284/18723 | 4.20e-03 | 3.41e-02 | 61 |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |