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Gene: SAMD1 |
Gene summary for SAMD1 |
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Gene information | Species | Human | Gene symbol | SAMD1 | Gene ID | 90378 |
Gene name | sterile alpha motif domain containing 1 | |
Gene Alias | SAMD1 | |
Cytomap | 19p13.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6SPF0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90378 | SAMD1 | LZE4T | Human | Esophagus | ESCC | 5.82e-04 | 8.32e-02 | 0.0811 |
90378 | SAMD1 | LZE7T | Human | Esophagus | ESCC | 1.05e-12 | 3.30e-01 | 0.0667 |
90378 | SAMD1 | LZE22T | Human | Esophagus | ESCC | 1.09e-02 | 2.71e-01 | 0.068 |
90378 | SAMD1 | LZE24T | Human | Esophagus | ESCC | 4.00e-06 | 1.33e-01 | 0.0596 |
90378 | SAMD1 | LZE21T | Human | Esophagus | ESCC | 1.12e-02 | 1.93e-01 | 0.0655 |
90378 | SAMD1 | LZE6T | Human | Esophagus | ESCC | 1.62e-03 | 2.44e-01 | 0.0845 |
90378 | SAMD1 | P1T-E | Human | Esophagus | ESCC | 3.48e-06 | 3.77e-01 | 0.0875 |
90378 | SAMD1 | P2T-E | Human | Esophagus | ESCC | 1.53e-09 | 1.50e-01 | 0.1177 |
90378 | SAMD1 | P4T-E | Human | Esophagus | ESCC | 7.34e-09 | 2.90e-01 | 0.1323 |
90378 | SAMD1 | P5T-E | Human | Esophagus | ESCC | 2.84e-14 | 2.99e-01 | 0.1327 |
90378 | SAMD1 | P8T-E | Human | Esophagus | ESCC | 1.27e-11 | 1.90e-01 | 0.0889 |
90378 | SAMD1 | P9T-E | Human | Esophagus | ESCC | 1.30e-07 | 2.59e-01 | 0.1131 |
90378 | SAMD1 | P10T-E | Human | Esophagus | ESCC | 3.15e-13 | 3.13e-01 | 0.116 |
90378 | SAMD1 | P12T-E | Human | Esophagus | ESCC | 1.43e-14 | 2.10e-01 | 0.1122 |
90378 | SAMD1 | P15T-E | Human | Esophagus | ESCC | 6.58e-12 | 1.82e-01 | 0.1149 |
90378 | SAMD1 | P16T-E | Human | Esophagus | ESCC | 9.44e-20 | 1.05e-01 | 0.1153 |
90378 | SAMD1 | P17T-E | Human | Esophagus | ESCC | 3.96e-08 | 2.62e-01 | 0.1278 |
90378 | SAMD1 | P20T-E | Human | Esophagus | ESCC | 6.69e-10 | 1.40e-01 | 0.1124 |
90378 | SAMD1 | P21T-E | Human | Esophagus | ESCC | 1.54e-27 | 3.73e-01 | 0.1617 |
90378 | SAMD1 | P22T-E | Human | Esophagus | ESCC | 2.89e-12 | 1.36e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SAMD1 | deletion | In_Frame_Del | rs777905778 | c.702_710delNNNNNNNNN | p.Glu234_Asp236del | p.E234_D236del | protein_coding | TCGA-EW-A1PB-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
SAMD1 | SNV | Missense_Mutation | rs770299017 | c.644G>A | p.Gly215Glu | p.G215E | protein_coding | tolerated(0.38) | probably_damaging(0.994) | TCGA-C5-A7UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
SAMD1 | SNV | Missense_Mutation | c.661N>C | p.Glu221Gln | p.E221Q | protein_coding | tolerated(0.15) | benign(0.006) | TCGA-EA-A411-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
SAMD1 | SNV | Missense_Mutation | rs779885748 | c.1282G>A | p.Asp428Asn | p.D428N | protein_coding | deleterious_low_confidence(0.02) | benign(0.022) | TCGA-EK-A2PL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
SAMD1 | SNV | Missense_Mutation | rs199764334 | c.932N>T | p.Ala311Val | p.A311V | protein_coding | tolerated(0.34) | possibly_damaging(0.676) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
SAMD1 | SNV | Missense_Mutation | c.1205N>A | p.Arg402His | p.R402H | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SAMD1 | SNV | Missense_Mutation | rs747195703 | c.859N>T | p.Arg287Trp | p.R287W | protein_coding | deleterious(0) | possibly_damaging(0.73) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SAMD1 | SNV | Missense_Mutation | rs539066946 | c.1087G>A | p.Glu363Lys | p.E363K | protein_coding | tolerated(0.23) | benign(0.231) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SAMD1 | SNV | Missense_Mutation | novel | c.852N>A | p.Asp284Glu | p.D284E | protein_coding | tolerated(0.19) | benign(0.019) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SAMD1 | SNV | Missense_Mutation | novel | c.1264T>C | p.Phe422Leu | p.F422L | protein_coding | tolerated(0.14) | benign(0.082) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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