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Gene: RTKN |
Gene summary for RTKN |
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Gene information | Species | Human | Gene symbol | RTKN | Gene ID | 6242 |
Gene name | rhotekin | |
Gene Alias | RTKN | |
Cytomap | 2p13.1 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | Q9BST9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6242 | RTKN | P23T-E | Human | Esophagus | ESCC | 6.93e-22 | 6.98e-01 | 0.108 |
6242 | RTKN | P24T-E | Human | Esophagus | ESCC | 4.16e-27 | 5.39e-01 | 0.1287 |
6242 | RTKN | P26T-E | Human | Esophagus | ESCC | 2.21e-30 | 6.03e-01 | 0.1276 |
6242 | RTKN | P27T-E | Human | Esophagus | ESCC | 1.28e-18 | 3.11e-01 | 0.1055 |
6242 | RTKN | P28T-E | Human | Esophagus | ESCC | 1.01e-63 | 1.23e+00 | 0.1149 |
6242 | RTKN | P30T-E | Human | Esophagus | ESCC | 9.39e-14 | 6.78e-01 | 0.137 |
6242 | RTKN | P31T-E | Human | Esophagus | ESCC | 1.52e-25 | 5.23e-01 | 0.1251 |
6242 | RTKN | P32T-E | Human | Esophagus | ESCC | 1.04e-19 | 4.92e-01 | 0.1666 |
6242 | RTKN | P36T-E | Human | Esophagus | ESCC | 2.42e-16 | 5.74e-01 | 0.1187 |
6242 | RTKN | P37T-E | Human | Esophagus | ESCC | 1.37e-19 | 5.83e-01 | 0.1371 |
6242 | RTKN | P38T-E | Human | Esophagus | ESCC | 4.39e-07 | 3.75e-01 | 0.127 |
6242 | RTKN | P40T-E | Human | Esophagus | ESCC | 4.72e-10 | 4.24e-01 | 0.109 |
6242 | RTKN | P42T-E | Human | Esophagus | ESCC | 2.40e-12 | 4.08e-01 | 0.1175 |
6242 | RTKN | P44T-E | Human | Esophagus | ESCC | 1.58e-06 | 1.26e-01 | 0.1096 |
6242 | RTKN | P47T-E | Human | Esophagus | ESCC | 8.29e-15 | 2.33e-01 | 0.1067 |
6242 | RTKN | P48T-E | Human | Esophagus | ESCC | 2.62e-25 | 4.13e-01 | 0.0959 |
6242 | RTKN | P49T-E | Human | Esophagus | ESCC | 1.52e-19 | 1.59e+00 | 0.1768 |
6242 | RTKN | P52T-E | Human | Esophagus | ESCC | 3.33e-40 | 7.98e-01 | 0.1555 |
6242 | RTKN | P54T-E | Human | Esophagus | ESCC | 5.81e-13 | 1.95e-01 | 0.0975 |
6242 | RTKN | P56T-E | Human | Esophagus | ESCC | 3.37e-03 | 8.23e-01 | 0.1613 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:009719310 | Cervix | CC | intrinsic apoptotic signaling pathway | 85/2311 | 288/18723 | 4.56e-15 | 6.46e-12 | 85 |
GO:200123310 | Cervix | CC | regulation of apoptotic signaling pathway | 96/2311 | 356/18723 | 4.08e-14 | 3.05e-11 | 96 |
GO:200124210 | Cervix | CC | regulation of intrinsic apoptotic signaling pathway | 52/2311 | 164/18723 | 5.06e-11 | 1.01e-08 | 52 |
GO:200123410 | Cervix | CC | negative regulation of apoptotic signaling pathway | 56/2311 | 224/18723 | 1.39e-07 | 6.70e-06 | 56 |
GO:00510904 | Cervix | CC | regulation of DNA-binding transcription factor activity | 87/2311 | 440/18723 | 4.85e-06 | 1.22e-04 | 87 |
GO:200124310 | Cervix | CC | negative regulation of intrinsic apoptotic signaling pathway | 28/2311 | 98/18723 | 1.31e-05 | 2.66e-04 | 28 |
GO:00510915 | Cervix | CC | positive regulation of DNA-binding transcription factor activity | 51/2311 | 260/18723 | 5.05e-04 | 4.92e-03 | 51 |
GO:00510923 | Cervix | CC | positive regulation of NF-kappaB transcription factor activity | 32/2311 | 152/18723 | 1.62e-03 | 1.25e-02 | 32 |
GO:009719315 | Cervix | HSIL_HPV | intrinsic apoptotic signaling pathway | 41/737 | 288/18723 | 8.91e-13 | 1.43e-09 | 41 |
GO:200123315 | Cervix | HSIL_HPV | regulation of apoptotic signaling pathway | 46/737 | 356/18723 | 1.23e-12 | 1.49e-09 | 46 |
GO:200124215 | Cervix | HSIL_HPV | regulation of intrinsic apoptotic signaling pathway | 27/737 | 164/18723 | 2.67e-10 | 7.02e-08 | 27 |
GO:200123415 | Cervix | HSIL_HPV | negative regulation of apoptotic signaling pathway | 27/737 | 224/18723 | 2.44e-07 | 1.45e-05 | 27 |
GO:005109211 | Cervix | HSIL_HPV | positive regulation of NF-kappaB transcription factor activity | 20/737 | 152/18723 | 2.25e-06 | 9.41e-05 | 20 |
GO:200124315 | Cervix | HSIL_HPV | negative regulation of intrinsic apoptotic signaling pathway | 15/737 | 98/18723 | 6.40e-06 | 2.30e-04 | 15 |
GO:005109012 | Cervix | HSIL_HPV | regulation of DNA-binding transcription factor activity | 35/737 | 440/18723 | 6.77e-05 | 1.58e-03 | 35 |
GO:005109112 | Cervix | HSIL_HPV | positive regulation of DNA-binding transcription factor activity | 24/737 | 260/18723 | 1.01e-04 | 2.16e-03 | 24 |
GO:000028115 | Esophagus | ESCC | mitotic cytokinesis | 58/8552 | 71/18723 | 4.34e-10 | 1.15e-08 | 58 |
GO:003250614 | Esophagus | ESCC | cytokinetic process | 35/8552 | 39/18723 | 9.38e-09 | 1.90e-07 | 35 |
GO:000091016 | Esophagus | ESCC | cytokinesis | 115/8552 | 173/18723 | 2.48e-08 | 4.68e-07 | 115 |
GO:006164015 | Esophagus | ESCC | cytoskeleton-dependent cytokinesis | 72/8552 | 100/18723 | 8.10e-08 | 1.39e-06 | 72 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RTKN | SNV | Missense_Mutation | c.1036N>A | p.Glu346Lys | p.E346K | Q9BST9 | protein_coding | deleterious(0) | possibly_damaging(0.843) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RTKN | SNV | Missense_Mutation | rs142913266 | c.895C>G | p.Arg299Gly | p.R299G | Q9BST9 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-BH-A18T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RTKN | insertion | Frame_Shift_Ins | novel | c.591_592insATCCTCCCGCCTCGGCCTCCCAAAGTGGTAGGATTACA | p.Ala198IlefsTer22 | p.A198Ifs*22 | Q9BST9 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
RTKN | SNV | Missense_Mutation | rs201347198 | c.1667N>A | p.Arg556His | p.R556H | Q9BST9 | protein_coding | tolerated_low_confidence(0.44) | benign(0) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RTKN | SNV | Missense_Mutation | c.111N>T | p.Glu37Asp | p.E37D | Q9BST9 | protein_coding | deleterious(0.05) | benign(0.182) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RTKN | SNV | Missense_Mutation | rs765799493 | c.1384N>A | p.Ala462Thr | p.A462T | Q9BST9 | protein_coding | deleterious(0.04) | benign(0.029) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RTKN | SNV | Missense_Mutation | rs374992298 | c.1633N>T | p.Arg545Trp | p.R545W | Q9BST9 | protein_coding | deleterious_low_confidence(0) | benign(0.153) | TCGA-AA-3526-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RTKN | SNV | Missense_Mutation | c.1627T>A | p.Ser543Thr | p.S543T | Q9BST9 | protein_coding | tolerated(0.09) | benign(0.02) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
RTKN | SNV | Missense_Mutation | c.194N>A | p.Arg65Gln | p.R65Q | Q9BST9 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RTKN | SNV | Missense_Mutation | c.722G>A | p.Ser241Asn | p.S241N | Q9BST9 | protein_coding | tolerated(0.28) | benign(0.003) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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