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Gene: RTF2 |
Gene summary for RTF2 |
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Gene information | Species | Human | Gene symbol | RTF2 | Gene ID | 51507 |
Gene name | replication termination factor 2 | |
Gene Alias | C20orf43 | |
Cytomap | 20q13.31 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | A0A0A0MQR2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51507 | RTF2 | DCIS2 | Human | Breast | DCIS | 1.34e-59 | 3.34e-01 | 0.0085 |
51507 | RTF2 | LZE2D | Human | Esophagus | HGIN | 6.44e-06 | 4.85e-01 | 0.0642 |
51507 | RTF2 | LZE3D | Human | Esophagus | HGIN | 6.21e-05 | 5.85e-01 | 0.0668 |
51507 | RTF2 | LZE4T | Human | Esophagus | ESCC | 4.65e-36 | 9.53e-01 | 0.0811 |
51507 | RTF2 | LZE5T | Human | Esophagus | ESCC | 6.95e-12 | 8.17e-01 | 0.0514 |
51507 | RTF2 | LZE7T | Human | Esophagus | ESCC | 5.23e-19 | 9.14e-01 | 0.0667 |
51507 | RTF2 | LZE8T | Human | Esophagus | ESCC | 8.94e-21 | 5.51e-01 | 0.067 |
51507 | RTF2 | LZE20T | Human | Esophagus | ESCC | 1.91e-25 | 6.97e-01 | 0.0662 |
51507 | RTF2 | LZE22D1 | Human | Esophagus | HGIN | 4.30e-07 | 3.26e-01 | 0.0595 |
51507 | RTF2 | LZE22T | Human | Esophagus | ESCC | 6.43e-20 | 8.93e-01 | 0.068 |
51507 | RTF2 | LZE24T | Human | Esophagus | ESCC | 3.85e-38 | 8.33e-01 | 0.0596 |
51507 | RTF2 | LZE22D3 | Human | Esophagus | HGIN | 1.73e-02 | 5.15e-01 | 0.0653 |
51507 | RTF2 | LZE21T | Human | Esophagus | ESCC | 2.26e-15 | 7.59e-01 | 0.0655 |
51507 | RTF2 | LZE6T | Human | Esophagus | ESCC | 4.85e-19 | 7.07e-01 | 0.0845 |
51507 | RTF2 | S014 | Human | Liver | HCC | 2.13e-57 | 1.67e+00 | 0.2254 |
51507 | RTF2 | S015 | Human | Liver | HCC | 4.83e-49 | 1.95e+00 | 0.2375 |
51507 | RTF2 | S016 | Human | Liver | HCC | 5.12e-52 | 1.66e+00 | 0.2243 |
51507 | RTF2 | S027 | Human | Liver | HCC | 3.10e-15 | 1.10e+00 | 0.2446 |
51507 | RTF2 | S028 | Human | Liver | HCC | 2.86e-40 | 1.42e+00 | 0.2503 |
51507 | RTF2 | S029 | Human | Liver | HCC | 1.33e-40 | 1.50e+00 | 0.2581 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00712418 | Breast | Precancer | cellular response to inorganic substance | 26/1080 | 226/18723 | 6.23e-04 | 7.78e-03 | 26 |
GO:007124113 | Breast | IDC | cellular response to inorganic substance | 29/1434 | 226/18723 | 4.28e-03 | 3.34e-02 | 29 |
GO:007124123 | Breast | DCIS | cellular response to inorganic substance | 29/1390 | 226/18723 | 2.75e-03 | 2.41e-02 | 29 |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:00062612 | Esophagus | ESCC | DNA-dependent DNA replication | 100/8552 | 151/18723 | 2.61e-07 | 3.94e-06 | 100 |
GO:007124117 | Esophagus | ESCC | cellular response to inorganic substance | 125/8552 | 226/18723 | 2.17e-03 | 9.67e-03 | 125 |
GO:1902969 | Esophagus | ESCC | mitotic DNA replication | 11/8552 | 14/18723 | 1.30e-02 | 4.27e-02 | 11 |
GO:00062601 | Liver | HCC | DNA replication | 146/7958 | 260/18723 | 5.68e-06 | 7.02e-05 | 146 |
GO:007124112 | Liver | HCC | cellular response to inorganic substance | 119/7958 | 226/18723 | 1.26e-03 | 6.92e-03 | 119 |
GO:0006261 | Liver | HCC | DNA-dependent DNA replication | 80/7958 | 151/18723 | 5.91e-03 | 2.44e-02 | 80 |
GO:00062606 | Thyroid | PTC | DNA replication | 114/5968 | 260/18723 | 3.09e-05 | 2.95e-04 | 114 |
GO:0071241110 | Thyroid | PTC | cellular response to inorganic substance | 92/5968 | 226/18723 | 3.01e-03 | 1.49e-02 | 92 |
GO:000626013 | Thyroid | ATC | DNA replication | 124/6293 | 260/18723 | 1.58e-06 | 1.93e-05 | 124 |
GO:007124124 | Thyroid | ATC | cellular response to inorganic substance | 98/6293 | 226/18723 | 1.35e-03 | 7.02e-03 | 98 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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