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Gene: RRP12 |
Gene summary for RRP12 |
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Gene information | Species | Human | Gene symbol | RRP12 | Gene ID | 23223 |
Gene name | ribosomal RNA processing 12 homolog | |
Gene Alias | KIAA0690 | |
Cytomap | 10q24.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KMR5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23223 | RRP12 | P27T-E | Human | Esophagus | ESCC | 3.11e-17 | 3.59e-01 | 0.1055 |
23223 | RRP12 | P28T-E | Human | Esophagus | ESCC | 8.49e-19 | 4.86e-01 | 0.1149 |
23223 | RRP12 | P30T-E | Human | Esophagus | ESCC | 2.58e-08 | 4.14e-01 | 0.137 |
23223 | RRP12 | P31T-E | Human | Esophagus | ESCC | 1.50e-12 | 2.34e-01 | 0.1251 |
23223 | RRP12 | P32T-E | Human | Esophagus | ESCC | 2.08e-11 | 1.70e-01 | 0.1666 |
23223 | RRP12 | P36T-E | Human | Esophagus | ESCC | 3.47e-07 | 4.34e-01 | 0.1187 |
23223 | RRP12 | P37T-E | Human | Esophagus | ESCC | 2.23e-05 | 1.55e-01 | 0.1371 |
23223 | RRP12 | P39T-E | Human | Esophagus | ESCC | 1.14e-06 | 2.33e-01 | 0.0894 |
23223 | RRP12 | P40T-E | Human | Esophagus | ESCC | 2.72e-10 | 3.55e-01 | 0.109 |
23223 | RRP12 | P42T-E | Human | Esophagus | ESCC | 5.48e-14 | 4.09e-01 | 0.1175 |
23223 | RRP12 | P44T-E | Human | Esophagus | ESCC | 3.14e-11 | 1.63e-01 | 0.1096 |
23223 | RRP12 | P47T-E | Human | Esophagus | ESCC | 4.56e-06 | 1.26e-01 | 0.1067 |
23223 | RRP12 | P48T-E | Human | Esophagus | ESCC | 3.13e-08 | 1.86e-01 | 0.0959 |
23223 | RRP12 | P52T-E | Human | Esophagus | ESCC | 8.39e-12 | 2.22e-01 | 0.1555 |
23223 | RRP12 | P54T-E | Human | Esophagus | ESCC | 2.36e-38 | 8.83e-01 | 0.0975 |
23223 | RRP12 | P56T-E | Human | Esophagus | ESCC | 1.26e-05 | 8.98e-01 | 0.1613 |
23223 | RRP12 | P57T-E | Human | Esophagus | ESCC | 2.14e-03 | 2.42e-01 | 0.0926 |
23223 | RRP12 | P61T-E | Human | Esophagus | ESCC | 6.45e-06 | 9.30e-02 | 0.099 |
23223 | RRP12 | P62T-E | Human | Esophagus | ESCC | 1.11e-23 | 6.61e-01 | 0.1302 |
23223 | RRP12 | P65T-E | Human | Esophagus | ESCC | 3.49e-14 | 3.45e-01 | 0.0978 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
GO:000636410 | Oral cavity | OSCC | rRNA processing | 172/7305 | 225/18723 | 1.57e-30 | 1.24e-27 | 172 |
GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
GO:001607210 | Oral cavity | OSCC | rRNA metabolic process | 176/7305 | 236/18723 | 6.51e-29 | 3.24e-26 | 176 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:0022613110 | Oral cavity | LP | ribonucleoprotein complex biogenesis | 259/4623 | 463/18723 | 7.20e-48 | 2.25e-44 | 259 |
GO:0042254110 | Oral cavity | LP | ribosome biogenesis | 173/4623 | 299/18723 | 8.97e-35 | 1.41e-31 | 173 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RRP12 | SNV | Missense_Mutation | rs202239906 | c.1846N>A | p.Asp616Asn | p.D616N | Q5JTH9 | protein_coding | tolerated(0.09) | benign(0.404) | TCGA-A2-A0YJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD |
RRP12 | SNV | Missense_Mutation | novel | c.278N>A | p.Gly93Asp | p.G93D | Q5JTH9 | protein_coding | tolerated(0.16) | benign(0.247) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RRP12 | SNV | Missense_Mutation | novel | c.3163G>C | p.Glu1055Gln | p.E1055Q | Q5JTH9 | protein_coding | tolerated(0.33) | benign(0.001) | TCGA-AN-A04D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RRP12 | SNV | Missense_Mutation | novel | c.302N>G | p.Asp101Gly | p.D101G | Q5JTH9 | protein_coding | deleterious(0.01) | possibly_damaging(0.735) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
RRP12 | SNV | Missense_Mutation | rs367633522 | c.217N>A | p.Glu73Lys | p.E73K | Q5JTH9 | protein_coding | tolerated(0.34) | benign(0.021) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
RRP12 | SNV | Missense_Mutation | novel | c.1279N>A | p.Pro427Thr | p.P427T | Q5JTH9 | protein_coding | tolerated(0.11) | benign(0.007) | TCGA-EW-A3E8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
RRP12 | insertion | In_Frame_Ins | novel | c.2629_2630insAGTTTAAAGGTAAAT | p.Ala877delinsGluPheLysGlyLysSer | p.A877delinsEFKGKS | Q5JTH9 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
RRP12 | insertion | Nonsense_Mutation | novel | c.303_304insCCAAATTAATCTTAATAATGT | p.Asp101_Cys102insProAsnTerSerTerTerCys | p.D101_C102insPN*S**C | Q5JTH9 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
RRP12 | deletion | Frame_Shift_Del | novel | c.2496delC | p.Lys833ArgfsTer5 | p.K833Rfs*5 | Q5JTH9 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
RRP12 | deletion | Frame_Shift_Del | novel | c.2088delG | p.Tyr697MetfsTer33 | p.Y697Mfs*33 | Q5JTH9 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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