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Gene: RRM2B |
Gene summary for RRM2B |
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Gene information | Species | Human | Gene symbol | RRM2B | Gene ID | 50484 |
Gene name | ribonucleotide reductase regulatory TP53 inducible subunit M2B | |
Gene Alias | MTDPS8A | |
Cytomap | 8q22.3 | |
Gene Type | protein-coding | GO ID | GO:0001655 | UniProtAcc | Q7LG56 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
50484 | RRM2B | P26T-E | Human | Esophagus | ESCC | 5.82e-16 | 3.69e-01 | 0.1276 |
50484 | RRM2B | P27T-E | Human | Esophagus | ESCC | 3.63e-15 | 2.89e-01 | 0.1055 |
50484 | RRM2B | P28T-E | Human | Esophagus | ESCC | 4.94e-13 | 2.71e-01 | 0.1149 |
50484 | RRM2B | P30T-E | Human | Esophagus | ESCC | 6.19e-09 | 4.22e-01 | 0.137 |
50484 | RRM2B | P31T-E | Human | Esophagus | ESCC | 4.84e-05 | 1.18e-01 | 0.1251 |
50484 | RRM2B | P32T-E | Human | Esophagus | ESCC | 2.51e-14 | 2.99e-01 | 0.1666 |
50484 | RRM2B | P36T-E | Human | Esophagus | ESCC | 1.03e-04 | 2.08e-01 | 0.1187 |
50484 | RRM2B | P37T-E | Human | Esophagus | ESCC | 1.33e-08 | 1.65e-01 | 0.1371 |
50484 | RRM2B | P38T-E | Human | Esophagus | ESCC | 2.92e-03 | 1.37e-01 | 0.127 |
50484 | RRM2B | P39T-E | Human | Esophagus | ESCC | 3.30e-10 | 1.79e-01 | 0.0894 |
50484 | RRM2B | P40T-E | Human | Esophagus | ESCC | 1.22e-05 | 1.84e-01 | 0.109 |
50484 | RRM2B | P42T-E | Human | Esophagus | ESCC | 1.13e-08 | 2.51e-01 | 0.1175 |
50484 | RRM2B | P44T-E | Human | Esophagus | ESCC | 1.29e-10 | 2.34e-01 | 0.1096 |
50484 | RRM2B | P47T-E | Human | Esophagus | ESCC | 1.09e-06 | 1.67e-01 | 0.1067 |
50484 | RRM2B | P48T-E | Human | Esophagus | ESCC | 2.48e-07 | 1.79e-01 | 0.0959 |
50484 | RRM2B | P49T-E | Human | Esophagus | ESCC | 5.15e-07 | 9.61e-01 | 0.1768 |
50484 | RRM2B | P52T-E | Human | Esophagus | ESCC | 3.15e-14 | 1.96e-01 | 0.1555 |
50484 | RRM2B | P54T-E | Human | Esophagus | ESCC | 8.88e-10 | 2.73e-01 | 0.0975 |
50484 | RRM2B | P56T-E | Human | Esophagus | ESCC | 1.28e-08 | 7.91e-01 | 0.1613 |
50484 | RRM2B | P57T-E | Human | Esophagus | ESCC | 1.05e-09 | 2.22e-01 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097193111 | Esophagus | ESCC | intrinsic apoptotic signaling pathway | 222/8552 | 288/18723 | 5.87e-28 | 2.02e-25 | 222 |
GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:2001242111 | Esophagus | ESCC | regulation of intrinsic apoptotic signaling pathway | 128/8552 | 164/18723 | 1.75e-17 | 1.50e-15 | 128 |
GO:2001234111 | Esophagus | ESCC | negative regulation of apoptotic signaling pathway | 161/8552 | 224/18723 | 1.24e-15 | 8.09e-14 | 161 |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:0072331111 | Esophagus | ESCC | signal transduction by p53 class mediator | 121/8552 | 163/18723 | 9.61e-14 | 4.69e-12 | 121 |
GO:2001243111 | Esophagus | ESCC | negative regulation of intrinsic apoptotic signaling pathway | 78/8552 | 98/18723 | 5.50e-12 | 2.10e-10 | 78 |
GO:1901796111 | Esophagus | ESCC | regulation of signal transduction by p53 class mediator | 70/8552 | 93/18723 | 5.69e-09 | 1.18e-07 | 70 |
GO:0072332111 | Esophagus | ESCC | intrinsic apoptotic signaling pathway by p53 class mediator | 59/8552 | 76/18723 | 1.22e-08 | 2.42e-07 | 59 |
GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
GO:0009117111 | Esophagus | ESCC | nucleotide metabolic process | 282/8552 | 489/18723 | 4.70e-08 | 8.50e-07 | 282 |
GO:0009141111 | Esophagus | ESCC | nucleoside triphosphate metabolic process | 78/8552 | 112/18723 | 2.36e-07 | 3.59e-06 | 78 |
GO:00062612 | Esophagus | ESCC | DNA-dependent DNA replication | 100/8552 | 151/18723 | 2.61e-07 | 3.94e-06 | 100 |
GO:000916516 | Esophagus | ESCC | nucleotide biosynthetic process | 150/8552 | 254/18723 | 1.12e-05 | 1.06e-04 | 150 |
GO:190129316 | Esophagus | ESCC | nucleoside phosphate biosynthetic process | 151/8552 | 256/18723 | 1.15e-05 | 1.08e-04 | 151 |
GO:1902253110 | Esophagus | ESCC | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 23/8552 | 29/18723 | 2.25e-04 | 1.40e-03 | 23 |
GO:000920012 | Esophagus | ESCC | deoxyribonucleoside triphosphate metabolic process | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
GO:000926212 | Esophagus | ESCC | deoxyribonucleotide metabolic process | 31/8552 | 44/18723 | 7.70e-04 | 3.99e-03 | 31 |
GO:00092633 | Esophagus | ESCC | deoxyribonucleotide biosynthetic process | 13/8552 | 15/18723 | 1.31e-03 | 6.26e-03 | 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0411524 | Esophagus | ESCC | p53 signaling pathway | 65/4205 | 74/8465 | 3.88e-12 | 6.50e-11 | 3.33e-11 | 65 |
hsa0048018 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa002405 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
hsa0411534 | Esophagus | ESCC | p53 signaling pathway | 65/4205 | 74/8465 | 3.88e-12 | 6.50e-11 | 3.33e-11 | 65 |
hsa0048019 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa0024012 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
hsa002402 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa0048022 | Liver | HCC | Glutathione metabolism | 42/4020 | 57/8465 | 5.00e-05 | 2.62e-04 | 1.46e-04 | 42 |
hsa009832 | Liver | HCC | Drug metabolism - other enzymes | 54/4020 | 80/8465 | 2.25e-04 | 1.09e-03 | 6.08e-04 | 54 |
hsa041156 | Liver | HCC | p53 signaling pathway | 46/4020 | 74/8465 | 7.64e-03 | 2.08e-02 | 1.16e-02 | 46 |
hsa002403 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa0048032 | Liver | HCC | Glutathione metabolism | 42/4020 | 57/8465 | 5.00e-05 | 2.62e-04 | 1.46e-04 | 42 |
hsa009833 | Liver | HCC | Drug metabolism - other enzymes | 54/4020 | 80/8465 | 2.25e-04 | 1.09e-03 | 6.08e-04 | 54 |
hsa0411511 | Liver | HCC | p53 signaling pathway | 46/4020 | 74/8465 | 7.64e-03 | 2.08e-02 | 1.16e-02 | 46 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RRM2B | SNV | Missense_Mutation | c.969N>A | p.Phe323Leu | p.F323L | Q7LG56 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.968) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RRM2B | SNV | Missense_Mutation | c.742N>A | p.Glu248Lys | p.E248K | Q7LG56 | protein_coding | tolerated_low_confidence(0.42) | benign(0.003) | TCGA-EA-A3HT-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
RRM2B | SNV | Missense_Mutation | rs370367329 | c.70N>A | p.Glu24Lys | p.E24K | Q7LG56 | protein_coding | tolerated_low_confidence(0.36) | benign(0) | TCGA-ZJ-AAXT-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
RRM2B | SNV | Missense_Mutation | c.226C>A | p.Pro76Thr | p.P76T | Q7LG56 | protein_coding | tolerated_low_confidence(0.63) | benign(0.006) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
RRM2B | SNV | Missense_Mutation | c.463N>G | p.Leu155Val | p.L155V | Q7LG56 | protein_coding | deleterious_low_confidence(0.01) | benign(0.262) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
RRM2B | SNV | Missense_Mutation | rs515726186 | c.328C>T | p.Arg110Cys | p.R110C | Q7LG56 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.597) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
RRM2B | insertion | Frame_Shift_Ins | novel | c.288_289insT | p.Ala97CysfsTer4 | p.A97Cfs*4 | Q7LG56 | protein_coding | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
RRM2B | SNV | Missense_Mutation | novel | c.481A>G | p.Thr161Ala | p.T161A | Q7LG56 | protein_coding | deleterious_low_confidence(0) | benign(0.036) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RRM2B | SNV | Missense_Mutation | novel | c.264C>A | p.Phe88Leu | p.F88L | Q7LG56 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.979) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RRM2B | SNV | Missense_Mutation | rs764136513 | c.521G>A | p.Arg174Gln | p.R174Q | Q7LG56 | protein_coding | tolerated_low_confidence(0.09) | benign(0.015) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
50484 | RRM2B | ENZYME, DRUGGABLE GENOME, DNA REPAIR | inhibitor | CHEMBL1200983 | GALLIUM NITRATE | |
50484 | RRM2B | ENZYME, DRUGGABLE GENOME, DNA REPAIR | inhibitor | CHEMBL1096882 | FLUDARABINE PHOSPHATE | |
50484 | RRM2B | ENZYME, DRUGGABLE GENOME, DNA REPAIR | MOTEXAFIN GADOLINIUM | |||
50484 | RRM2B | ENZYME, DRUGGABLE GENOME, DNA REPAIR | GEMCITABINE | GEMCITABINE | ||
50484 | RRM2B | ENZYME, DRUGGABLE GENOME, DNA REPAIR | inhibitor | CHEMBL1750 | CLOFARABINE | |
50484 | RRM2B | ENZYME, DRUGGABLE GENOME, DNA REPAIR | inhibitor | CHEMBL467 | HYDROXYUREA | |
50484 | RRM2B | ENZYME, DRUGGABLE GENOME, DNA REPAIR | cladribine | CLADRIBINE | 24024897 | |
50484 | RRM2B | ENZYME, DRUGGABLE GENOME, DNA REPAIR | inhibitor | CHEMBL1637 | GEMCITABINE HYDROCHLORIDE | |
50484 | RRM2B | ENZYME, DRUGGABLE GENOME, DNA REPAIR | LOR-2040 | |||
50484 | RRM2B | ENZYME, DRUGGABLE GENOME, DNA REPAIR | inhibitor | CHEMBL2105467 | TEZACITABINE |
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