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Gene: RPUSD1 |
Gene summary for RPUSD1 |
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Gene information | Species | Human | Gene symbol | RPUSD1 | Gene ID | 113000 |
Gene name | RNA pseudouridine synthase domain containing 1 | |
Gene Alias | C16orf40 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000154 | UniProtAcc | H3BUN6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
113000 | RPUSD1 | P22T-E | Human | Esophagus | ESCC | 1.40e-19 | 3.74e-01 | 0.1236 |
113000 | RPUSD1 | P23T-E | Human | Esophagus | ESCC | 3.24e-29 | 5.69e-01 | 0.108 |
113000 | RPUSD1 | P24T-E | Human | Esophagus | ESCC | 3.03e-16 | 3.01e-01 | 0.1287 |
113000 | RPUSD1 | P26T-E | Human | Esophagus | ESCC | 1.14e-27 | 4.38e-01 | 0.1276 |
113000 | RPUSD1 | P27T-E | Human | Esophagus | ESCC | 1.13e-25 | 3.90e-01 | 0.1055 |
113000 | RPUSD1 | P28T-E | Human | Esophagus | ESCC | 2.72e-29 | 5.19e-01 | 0.1149 |
113000 | RPUSD1 | P30T-E | Human | Esophagus | ESCC | 2.43e-24 | 7.96e-01 | 0.137 |
113000 | RPUSD1 | P31T-E | Human | Esophagus | ESCC | 1.42e-21 | 3.86e-01 | 0.1251 |
113000 | RPUSD1 | P32T-E | Human | Esophagus | ESCC | 2.62e-28 | 5.46e-01 | 0.1666 |
113000 | RPUSD1 | P36T-E | Human | Esophagus | ESCC | 5.52e-20 | 4.72e-01 | 0.1187 |
113000 | RPUSD1 | P37T-E | Human | Esophagus | ESCC | 4.92e-18 | 4.14e-01 | 0.1371 |
113000 | RPUSD1 | P39T-E | Human | Esophagus | ESCC | 3.98e-16 | 2.44e-01 | 0.0894 |
113000 | RPUSD1 | P40T-E | Human | Esophagus | ESCC | 4.82e-12 | 2.49e-01 | 0.109 |
113000 | RPUSD1 | P42T-E | Human | Esophagus | ESCC | 1.79e-12 | 2.87e-01 | 0.1175 |
113000 | RPUSD1 | P44T-E | Human | Esophagus | ESCC | 7.65e-10 | 1.58e-01 | 0.1096 |
113000 | RPUSD1 | P47T-E | Human | Esophagus | ESCC | 7.46e-15 | 1.80e-01 | 0.1067 |
113000 | RPUSD1 | P48T-E | Human | Esophagus | ESCC | 8.50e-13 | 2.75e-01 | 0.0959 |
113000 | RPUSD1 | P49T-E | Human | Esophagus | ESCC | 1.12e-12 | 8.59e-01 | 0.1768 |
113000 | RPUSD1 | P52T-E | Human | Esophagus | ESCC | 7.34e-38 | 7.29e-01 | 0.1555 |
113000 | RPUSD1 | P54T-E | Human | Esophagus | ESCC | 2.02e-16 | 3.65e-01 | 0.0975 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00015221 | Esophagus | ESCC | pseudouridine synthesis | 16/8552 | 18/18723 | 1.78e-04 | 1.15e-03 | 16 |
GO:0000154 | Esophagus | ESCC | rRNA modification | 26/8552 | 37/18723 | 2.16e-03 | 9.62e-03 | 26 |
GO:00311182 | Esophagus | ESCC | rRNA pseudouridine synthesis | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:0009451 | Liver | HCC | RNA modification | 101/7958 | 167/18723 | 2.02e-06 | 2.78e-05 | 101 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
GO:000636410 | Oral cavity | OSCC | rRNA processing | 172/7305 | 225/18723 | 1.57e-30 | 1.24e-27 | 172 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPUSD1 | SNV | Missense_Mutation | rs752096465 | c.250N>A | p.Gly84Ser | p.G84S | Q9UJJ7 | protein_coding | tolerated(0.12) | possibly_damaging(0.84) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
RPUSD1 | SNV | Missense_Mutation | rs763994085 | c.283G>A | p.Val95Met | p.V95M | Q9UJJ7 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-BH-A42U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPUSD1 | SNV | Missense_Mutation | c.524A>C | p.Gln175Pro | p.Q175P | Q9UJJ7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RPUSD1 | SNV | Missense_Mutation | c.359N>A | p.Arg120Lys | p.R120K | Q9UJJ7 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
RPUSD1 | SNV | Missense_Mutation | c.277N>T | p.Arg93Trp | p.R93W | Q9UJJ7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
RPUSD1 | SNV | Missense_Mutation | c.278N>T | p.Arg93Leu | p.R93L | Q9UJJ7 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
RPUSD1 | SNV | Missense_Mutation | rs754419281 | c.445G>A | p.Val149Met | p.V149M | Q9UJJ7 | protein_coding | tolerated(0.27) | benign(0.035) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPUSD1 | SNV | Missense_Mutation | rs144681546 | c.310C>T | p.Arg104Trp | p.R104W | Q9UJJ7 | protein_coding | deleterious(0) | possibly_damaging(0.511) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPUSD1 | SNV | Missense_Mutation | rs370324017 | c.208A>G | p.Thr70Ala | p.T70A | Q9UJJ7 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPUSD1 | SNV | Missense_Mutation | rs775498059 | c.82N>G | p.Arg28Gly | p.R28G | Q9UJJ7 | protein_coding | tolerated(0.1) | probably_damaging(0.925) | TCGA-34-5232-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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