![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: RNF7 |
Gene summary for RNF7 |
![]() |
Gene information | Species | Human | Gene symbol | RNF7 | Gene ID | 9616 |
Gene name | ring finger protein 7 | |
Gene Alias | CKBBP1 | |
Cytomap | 3q23 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9UBF6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9616 | RNF7 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.19e-35 | -2.59e-01 | -0.1875 |
9616 | RNF7 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 3.42e-33 | -4.72e-01 | -0.1883 |
9616 | RNF7 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 4.51e-26 | -3.04e-01 | -0.1934 |
9616 | RNF7 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 6.90e-46 | -3.52e-01 | -0.1917 |
9616 | RNF7 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.68e-45 | -3.77e-01 | -0.1916 |
9616 | RNF7 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 4.70e-08 | -5.68e-02 | -0.1269 |
9616 | RNF7 | LZE2T | Human | Esophagus | ESCC | 2.91e-09 | 1.78e+00 | 0.082 |
9616 | RNF7 | LZE4T | Human | Esophagus | ESCC | 1.07e-33 | 1.83e+00 | 0.0811 |
9616 | RNF7 | LZE5T | Human | Esophagus | ESCC | 2.61e-02 | 7.92e-01 | 0.0514 |
9616 | RNF7 | LZE7T | Human | Esophagus | ESCC | 1.36e-17 | 1.85e+00 | 0.0667 |
9616 | RNF7 | LZE8T | Human | Esophagus | ESCC | 5.43e-14 | 1.20e+00 | 0.067 |
9616 | RNF7 | LZE20T | Human | Esophagus | ESCC | 1.13e-09 | 9.30e-01 | 0.0662 |
9616 | RNF7 | LZE22T | Human | Esophagus | ESCC | 7.29e-10 | 1.51e+00 | 0.068 |
9616 | RNF7 | LZE24T | Human | Esophagus | ESCC | 6.69e-41 | 2.00e+00 | 0.0596 |
9616 | RNF7 | LZE6T | Human | Esophagus | ESCC | 3.10e-13 | 1.44e+00 | 0.0845 |
9616 | RNF7 | P1T-E | Human | Esophagus | ESCC | 8.55e-25 | 2.10e+00 | 0.0875 |
9616 | RNF7 | P2T-E | Human | Esophagus | ESCC | 4.86e-111 | 2.81e+00 | 0.1177 |
9616 | RNF7 | P4T-E | Human | Esophagus | ESCC | 4.82e-75 | 2.64e+00 | 0.1323 |
9616 | RNF7 | P5T-E | Human | Esophagus | ESCC | 3.42e-83 | 2.06e+00 | 0.1327 |
9616 | RNF7 | P8T-E | Human | Esophagus | ESCC | 6.75e-74 | 1.86e+00 | 0.0889 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00451162 | Cervix | CC | protein neddylation | 7/2311 | 18/18723 | 3.99e-03 | 2.48e-02 | 7 |
GO:00451163 | Endometrium | AEH | protein neddylation | 7/2100 | 18/18723 | 2.29e-03 | 1.74e-02 | 7 |
GO:004511611 | Endometrium | EEC | protein neddylation | 7/2168 | 18/18723 | 2.76e-03 | 1.97e-02 | 7 |
GO:004511614 | Esophagus | ESCC | protein neddylation | 15/8552 | 18/18723 | 1.20e-03 | 5.88e-03 | 15 |
GO:0045116 | Liver | Cirrhotic | protein neddylation | 11/4634 | 18/18723 | 1.13e-03 | 7.73e-03 | 11 |
GO:00451161 | Liver | HCC | protein neddylation | 15/7958 | 18/18723 | 4.74e-04 | 3.12e-03 | 15 |
GO:0051775 | Liver | HCC | response to redox state | 12/7958 | 15/18723 | 3.56e-03 | 1.59e-02 | 12 |
GO:0043687 | Liver | HCC | post-translational protein modification | 24/7958 | 37/18723 | 5.03e-03 | 2.11e-02 | 24 |
GO:00451165 | Oral cavity | OSCC | protein neddylation | 13/7305 | 18/18723 | 4.45e-03 | 1.79e-02 | 13 |
GO:004511613 | Oral cavity | LP | protein neddylation | 11/4623 | 18/18723 | 1.11e-03 | 9.13e-03 | 11 |
GO:004511621 | Oral cavity | NEOLP | protein neddylation | 7/2005 | 18/18723 | 1.75e-03 | 1.21e-02 | 7 |
GO:00451164 | Prostate | BPH | protein neddylation | 10/3107 | 18/18723 | 1.87e-04 | 1.55e-03 | 10 |
GO:00517752 | Prostate | BPH | response to redox state | 8/3107 | 15/18723 | 1.21e-03 | 7.41e-03 | 8 |
GO:004511612 | Prostate | Tumor | protein neddylation | 10/3246 | 18/18723 | 2.72e-04 | 2.24e-03 | 10 |
GO:00517751 | Prostate | Tumor | response to redox state | 8/3246 | 15/18723 | 1.63e-03 | 9.79e-03 | 8 |
GO:00451167 | Skin | AK | protein neddylation | 7/1910 | 18/18723 | 1.31e-03 | 9.86e-03 | 7 |
GO:004511615 | Skin | cSCC | protein neddylation | 14/4864 | 18/18723 | 6.37e-06 | 8.92e-05 | 14 |
GO:004511616 | Thyroid | PTC | protein neddylation | 13/5968 | 18/18723 | 5.21e-04 | 3.37e-03 | 13 |
GO:00517753 | Thyroid | PTC | response to redox state | 11/5968 | 15/18723 | 1.19e-03 | 6.84e-03 | 11 |
GO:005177511 | Thyroid | ATC | response to redox state | 12/6293 | 15/18723 | 3.10e-04 | 1.94e-03 | 12 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0412014 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa0517016 | Cervix | CC | Human immunodeficiency virus 1 infection | 55/1267 | 212/8465 | 1.80e-05 | 1.42e-04 | 8.40e-05 | 55 |
hsa0412015 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa0517017 | Cervix | CC | Human immunodeficiency virus 1 infection | 55/1267 | 212/8465 | 1.80e-05 | 1.42e-04 | 8.40e-05 | 55 |
hsa0412016 | Endometrium | AEH | Ubiquitin mediated proteolysis | 41/1197 | 142/8465 | 3.42e-06 | 4.27e-05 | 3.13e-05 | 41 |
hsa0517018 | Endometrium | AEH | Human immunodeficiency virus 1 infection | 43/1197 | 212/8465 | 8.19e-03 | 4.22e-02 | 3.09e-02 | 43 |
hsa0412017 | Endometrium | AEH | Ubiquitin mediated proteolysis | 41/1197 | 142/8465 | 3.42e-06 | 4.27e-05 | 3.13e-05 | 41 |
hsa0517019 | Endometrium | AEH | Human immunodeficiency virus 1 infection | 43/1197 | 212/8465 | 8.19e-03 | 4.22e-02 | 3.09e-02 | 43 |
hsa0412023 | Endometrium | EEC | Ubiquitin mediated proteolysis | 41/1237 | 142/8465 | 7.86e-06 | 9.58e-05 | 7.14e-05 | 41 |
hsa0517025 | Endometrium | EEC | Human immunodeficiency virus 1 infection | 44/1237 | 212/8465 | 8.86e-03 | 4.05e-02 | 3.02e-02 | 44 |
hsa0412033 | Endometrium | EEC | Ubiquitin mediated proteolysis | 41/1237 | 142/8465 | 7.86e-06 | 9.58e-05 | 7.14e-05 | 41 |
hsa0517035 | Endometrium | EEC | Human immunodeficiency virus 1 infection | 44/1237 | 212/8465 | 8.86e-03 | 4.05e-02 | 3.02e-02 | 44 |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa05170210 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0517038 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa0412021 | Liver | Cirrhotic | Ubiquitin mediated proteolysis | 72/2530 | 142/8465 | 1.32e-07 | 1.97e-06 | 1.21e-06 | 72 |
hsa0412031 | Liver | Cirrhotic | Ubiquitin mediated proteolysis | 72/2530 | 142/8465 | 1.32e-07 | 1.97e-06 | 1.21e-06 | 72 |
hsa0412041 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa051709 | Liver | HCC | Human immunodeficiency virus 1 infection | 125/4020 | 212/8465 | 4.51e-04 | 1.94e-03 | 1.08e-03 | 125 |
Page: 1 2 3 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNF7 | SNV | Missense_Mutation | novel | c.293N>A | p.Arg98His | p.R98H | Q9UBF6 | protein_coding | tolerated(0.1) | benign(0.196) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RNF7 | SNV | Missense_Mutation | c.296N>C | p.Cys99Ser | p.C99S | Q9UBF6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | |
RNF7 | SNV | Missense_Mutation | c.116N>T | p.Ala39Val | p.A39V | Q9UBF6 | protein_coding | deleterious(0) | probably_damaging(0.914) | TCGA-DM-A28M-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RNF7 | SNV | Missense_Mutation | novel | c.319G>A | p.Val107Met | p.V107M | Q9UBF6 | protein_coding | tolerated(0.06) | benign(0.045) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
RNF7 | SNV | Missense_Mutation | novel | c.119N>C | p.Met40Thr | p.M40T | Q9UBF6 | protein_coding | tolerated(0.06) | benign(0.028) | TCGA-FI-A2F9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RNF7 | SNV | Missense_Mutation | c.131N>G | p.Asp44Gly | p.D44G | Q9UBF6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-8094-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
RNF7 | SNV | Missense_Mutation | c.57N>G | p.Ser19Arg | p.S19R | Q9UBF6 | protein_coding | tolerated(0.1) | benign(0.023) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RNF7 | SNV | Missense_Mutation | novel | c.65N>A | p.Ser22Tyr | p.S22Y | Q9UBF6 | protein_coding | deleterious(0.01) | benign(0.276) | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
RNF7 | SNV | Missense_Mutation | c.185T>G | p.Leu62Arg | p.L62R | Q9UBF6 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-ET-A3BT-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |