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Gene: RNF19B |
Gene summary for RNF19B |
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Gene information | Species | Human | Gene symbol | RNF19B | Gene ID | 127544 |
Gene name | ring finger protein 19B | |
Gene Alias | IBRDC3 | |
Cytomap | 1p35.1 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q6ZMZ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
127544 | RNF19B | P31T-E | Human | Esophagus | ESCC | 3.20e-14 | 7.23e-02 | 0.1251 |
127544 | RNF19B | P32T-E | Human | Esophagus | ESCC | 2.13e-14 | 1.01e-01 | 0.1666 |
127544 | RNF19B | P36T-E | Human | Esophagus | ESCC | 3.42e-03 | 1.18e-01 | 0.1187 |
127544 | RNF19B | P37T-E | Human | Esophagus | ESCC | 9.01e-11 | 2.28e-01 | 0.1371 |
127544 | RNF19B | P39T-E | Human | Esophagus | ESCC | 4.60e-07 | 1.80e-03 | 0.0894 |
127544 | RNF19B | P40T-E | Human | Esophagus | ESCC | 1.92e-05 | 2.48e-01 | 0.109 |
127544 | RNF19B | P42T-E | Human | Esophagus | ESCC | 1.84e-06 | 1.94e-01 | 0.1175 |
127544 | RNF19B | P44T-E | Human | Esophagus | ESCC | 2.03e-05 | -6.28e-02 | 0.1096 |
127544 | RNF19B | P47T-E | Human | Esophagus | ESCC | 1.33e-08 | 2.58e-02 | 0.1067 |
127544 | RNF19B | P48T-E | Human | Esophagus | ESCC | 1.32e-05 | 2.26e-01 | 0.0959 |
127544 | RNF19B | P49T-E | Human | Esophagus | ESCC | 3.47e-02 | 6.64e-01 | 0.1768 |
127544 | RNF19B | P52T-E | Human | Esophagus | ESCC | 7.70e-04 | 1.88e-01 | 0.1555 |
127544 | RNF19B | P54T-E | Human | Esophagus | ESCC | 2.78e-13 | 4.35e-01 | 0.0975 |
127544 | RNF19B | P57T-E | Human | Esophagus | ESCC | 2.38e-07 | 1.88e-02 | 0.0926 |
127544 | RNF19B | P61T-E | Human | Esophagus | ESCC | 6.95e-08 | 1.30e-01 | 0.099 |
127544 | RNF19B | P62T-E | Human | Esophagus | ESCC | 2.63e-11 | 2.86e-01 | 0.1302 |
127544 | RNF19B | P65T-E | Human | Esophagus | ESCC | 3.20e-12 | -3.21e-02 | 0.0978 |
127544 | RNF19B | P74T-E | Human | Esophagus | ESCC | 1.56e-02 | -4.26e-02 | 0.1479 |
127544 | RNF19B | P75T-E | Human | Esophagus | ESCC | 1.29e-12 | 2.34e-01 | 0.1125 |
127544 | RNF19B | P79T-E | Human | Esophagus | ESCC | 4.87e-05 | -1.25e-01 | 0.1154 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:0042176111 | Esophagus | ESCC | regulation of protein catabolic process | 280/8552 | 391/18723 | 8.65e-26 | 2.39e-23 | 280 |
GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
GO:1903362111 | Esophagus | ESCC | regulation of cellular protein catabolic process | 188/8552 | 255/18723 | 5.12e-20 | 6.62e-18 | 188 |
GO:0045862111 | Esophagus | ESCC | positive regulation of proteolysis | 256/8552 | 372/18723 | 7.88e-20 | 9.43e-18 | 256 |
GO:1903050111 | Esophagus | ESCC | regulation of proteolysis involved in cellular protein catabolic process | 163/8552 | 221/18723 | 1.44e-17 | 1.27e-15 | 163 |
GO:0061136111 | Esophagus | ESCC | regulation of proteasomal protein catabolic process | 142/8552 | 187/18723 | 2.40e-17 | 2.00e-15 | 142 |
GO:000020917 | Esophagus | ESCC | protein polyubiquitination | 170/8552 | 236/18723 | 1.40e-16 | 1.09e-14 | 170 |
GO:0045732111 | Esophagus | ESCC | positive regulation of protein catabolic process | 167/8552 | 231/18723 | 1.47e-16 | 1.14e-14 | 167 |
GO:0032434111 | Esophagus | ESCC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 107/8552 | 134/18723 | 4.06e-16 | 2.93e-14 | 107 |
GO:2000058111 | Esophagus | ESCC | regulation of ubiquitin-dependent protein catabolic process | 125/8552 | 164/18723 | 1.17e-15 | 7.76e-14 | 125 |
GO:1903364111 | Esophagus | ESCC | positive regulation of cellular protein catabolic process | 117/8552 | 155/18723 | 3.25e-14 | 1.66e-12 | 117 |
GO:1901800110 | Esophagus | ESCC | positive regulation of proteasomal protein catabolic process | 91/8552 | 114/18723 | 6.74e-14 | 3.34e-12 | 91 |
GO:1903052110 | Esophagus | ESCC | positive regulation of proteolysis involved in cellular protein catabolic process | 101/8552 | 133/18723 | 9.58e-13 | 4.19e-11 | 101 |
GO:0032436111 | Esophagus | ESCC | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 72/8552 | 90/18723 | 2.30e-11 | 7.87e-10 | 72 |
GO:2000060111 | Esophagus | ESCC | positive regulation of ubiquitin-dependent protein catabolic process | 81/8552 | 107/18723 | 2.23e-10 | 6.34e-09 | 81 |
GO:00518658 | Esophagus | ESCC | protein autoubiquitination | 47/8552 | 73/18723 | 9.72e-04 | 4.93e-03 | 47 |
GO:001049822 | Liver | HCC | proteasomal protein catabolic process | 351/7958 | 490/18723 | 6.92e-40 | 1.46e-36 | 351 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNF19B | SNV | Missense_Mutation | c.457G>C | p.Glu153Gln | p.E153Q | Q6ZMZ0 | protein_coding | tolerated(0.08) | possibly_damaging(0.709) | TCGA-C8-A1HK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RNF19B | insertion | Frame_Shift_Ins | novel | c.1834_1835insATGAGGTGTGTCAAAGAGTGTACATATGTATGTGTGTA | p.Leu612HisfsTer69 | p.L612Hfs*69 | Q6ZMZ0 | protein_coding | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
RNF19B | insertion | Nonsense_Mutation | novel | c.1278_1279insTCTCAGGGGGCACGCTGAGTGGCGGCATTCTCTCCAG | p.Ile427SerfsTer6 | p.I427Sfs*6 | Q6ZMZ0 | protein_coding | TCGA-AO-A03R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
RNF19B | insertion | Nonsense_Mutation | novel | c.1298_1299insGTTTTAAATTTTAGTTTTCTCATCTAAAATTGAGGCTATT | p.Tyr433Ter | p.Y433* | Q6ZMZ0 | protein_coding | TCGA-B6-A0IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
RNF19B | SNV | Missense_Mutation | c.1325G>A | p.Arg442His | p.R442H | Q6ZMZ0 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-C5-A1M8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
RNF19B | SNV | Missense_Mutation | novel | c.1547N>G | p.Phe516Cys | p.F516C | Q6ZMZ0 | protein_coding | tolerated(0.08) | possibly_damaging(0.72) | TCGA-AA-3955-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | capecitabine | CR |
RNF19B | SNV | Missense_Mutation | novel | c.1211N>T | p.Gly404Val | p.G404V | Q6ZMZ0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RNF19B | SNV | Missense_Mutation | novel | c.1700G>A | p.Arg567His | p.R567H | Q6ZMZ0 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RNF19B | SNV | Missense_Mutation | c.1328G>T | p.Gly443Val | p.G443V | Q6ZMZ0 | protein_coding | deleterious(0.01) | probably_damaging(0.976) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
RNF19B | SNV | Missense_Mutation | c.1346G>A | p.Ser449Asn | p.S449N | Q6ZMZ0 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-DM-A1DA-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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