![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: RMI2 |
Gene summary for RMI2 |
![]() |
Gene information | Species | Human | Gene symbol | RMI2 | Gene ID | 116028 |
Gene name | RecQ mediated genome instability 2 | |
Gene Alias | BLAP18 | |
Cytomap | 16p13.13 | |
Gene Type | protein-coding | GO ID | GO:0000018 | UniProtAcc | Q96E14 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
116028 | RMI2 | P30T-E | Human | Esophagus | ESCC | 6.07e-03 | 1.16e-01 | 0.137 |
116028 | RMI2 | P31T-E | Human | Esophagus | ESCC | 7.98e-13 | 2.81e-01 | 0.1251 |
116028 | RMI2 | P32T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.74e-01 | 0.1666 |
116028 | RMI2 | P36T-E | Human | Esophagus | ESCC | 4.04e-02 | 2.34e-01 | 0.1187 |
116028 | RMI2 | P37T-E | Human | Esophagus | ESCC | 7.84e-08 | 2.06e-01 | 0.1371 |
116028 | RMI2 | P39T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.09e-01 | 0.0894 |
116028 | RMI2 | P40T-E | Human | Esophagus | ESCC | 1.21e-03 | 1.90e-01 | 0.109 |
116028 | RMI2 | P42T-E | Human | Esophagus | ESCC | 9.78e-09 | 2.79e-01 | 0.1175 |
116028 | RMI2 | P47T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.31e-01 | 0.1067 |
116028 | RMI2 | P49T-E | Human | Esophagus | ESCC | 4.53e-04 | 6.70e-01 | 0.1768 |
116028 | RMI2 | P52T-E | Human | Esophagus | ESCC | 9.67e-18 | 3.46e-01 | 0.1555 |
116028 | RMI2 | P54T-E | Human | Esophagus | ESCC | 5.08e-08 | 1.68e-01 | 0.0975 |
116028 | RMI2 | P57T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.20e-01 | 0.0926 |
116028 | RMI2 | P61T-E | Human | Esophagus | ESCC | 1.21e-02 | 1.30e-01 | 0.099 |
116028 | RMI2 | P62T-E | Human | Esophagus | ESCC | 5.03e-11 | 2.77e-01 | 0.1302 |
116028 | RMI2 | P65T-E | Human | Esophagus | ESCC | 1.52e-14 | 2.88e-01 | 0.0978 |
116028 | RMI2 | P74T-E | Human | Esophagus | ESCC | 5.58e-06 | 1.26e-01 | 0.1479 |
116028 | RMI2 | P75T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.03e-01 | 0.1125 |
116028 | RMI2 | P76T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.86e-01 | 0.1207 |
116028 | RMI2 | P79T-E | Human | Esophagus | ESCC | 9.53e-09 | 2.29e-01 | 0.1154 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:003304416 | Esophagus | ESCC | regulation of chromosome organization | 145/8552 | 187/18723 | 3.80e-19 | 4.31e-17 | 145 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:005105215 | Esophagus | ESCC | regulation of DNA metabolic process | 232/8552 | 359/18723 | 2.40e-13 | 1.13e-11 | 232 |
GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
GO:2001020110 | Esophagus | ESCC | regulation of response to DNA damage stimulus | 145/8552 | 219/18723 | 5.97e-10 | 1.50e-08 | 145 |
GO:00519833 | Esophagus | ESCC | regulation of chromosome segregation | 67/8552 | 91/18723 | 5.42e-08 | 9.66e-07 | 67 |
GO:00330452 | Esophagus | ESCC | regulation of sister chromatid segregation | 55/8552 | 72/18723 | 1.03e-07 | 1.69e-06 | 55 |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:00062826 | Esophagus | ESCC | regulation of DNA repair | 82/8552 | 130/18723 | 4.65e-05 | 3.66e-04 | 82 |
GO:200102112 | Esophagus | ESCC | negative regulation of response to DNA damage stimulus | 54/8552 | 81/18723 | 1.09e-04 | 7.64e-04 | 54 |
GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
GO:20007793 | Esophagus | ESCC | regulation of double-strand break repair | 52/8552 | 85/18723 | 2.86e-03 | 1.21e-02 | 52 |
GO:00007241 | Esophagus | ESCC | double-strand break repair via homologous recombination | 79/8552 | 138/18723 | 4.05e-03 | 1.62e-02 | 79 |
GO:00007251 | Esophagus | ESCC | recombinational repair | 80/8552 | 140/18723 | 4.10e-03 | 1.63e-02 | 80 |
GO:00008193 | Oral cavity | OSCC | sister chromatid segregation | 135/7305 | 202/18723 | 8.88e-16 | 6.52e-14 | 135 |
GO:00070592 | Oral cavity | OSCC | chromosome segregation | 206/7305 | 346/18723 | 5.82e-15 | 3.76e-13 | 206 |
GO:00330448 | Oral cavity | OSCC | regulation of chromosome organization | 123/7305 | 187/18723 | 9.87e-14 | 5.17e-12 | 123 |
GO:00062603 | Oral cavity | OSCC | DNA replication | 159/7305 | 260/18723 | 3.25e-13 | 1.59e-11 | 159 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RMI2 | SNV | Missense_Mutation | c.431G>T | p.Arg144Met | p.R144M | Q96E14 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
RMI2 | SNV | Missense_Mutation | novel | c.300N>T | p.Lys100Asn | p.K100N | Q96E14 | protein_coding | tolerated(0.12) | probably_damaging(0.971) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RMI2 | SNV | Missense_Mutation | novel | c.371N>C | p.Asp124Ala | p.D124A | Q96E14 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
RMI2 | SNV | Missense_Mutation | novel | c.208N>T | p.Gly70Cys | p.G70C | Q96E14 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-56-8305-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |