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Gene: RITA1 |
Gene summary for RITA1 |
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Gene information | Species | Human | Gene symbol | RITA1 | Gene ID | 84934 |
Gene name | RBPJ interacting and tubulin associated 1 | |
Gene Alias | C12orf52 | |
Cytomap | 12q24.13 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q96K30 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84934 | RITA1 | P23T-E | Human | Esophagus | ESCC | 1.78e-25 | 4.84e-01 | 0.108 |
84934 | RITA1 | P24T-E | Human | Esophagus | ESCC | 3.28e-14 | 2.48e-01 | 0.1287 |
84934 | RITA1 | P26T-E | Human | Esophagus | ESCC | 3.19e-20 | 3.42e-01 | 0.1276 |
84934 | RITA1 | P27T-E | Human | Esophagus | ESCC | 1.40e-21 | 3.71e-01 | 0.1055 |
84934 | RITA1 | P28T-E | Human | Esophagus | ESCC | 1.65e-15 | 3.06e-01 | 0.1149 |
84934 | RITA1 | P30T-E | Human | Esophagus | ESCC | 5.31e-17 | 4.30e-01 | 0.137 |
84934 | RITA1 | P31T-E | Human | Esophagus | ESCC | 1.59e-16 | 2.83e-01 | 0.1251 |
84934 | RITA1 | P32T-E | Human | Esophagus | ESCC | 2.20e-17 | 3.07e-01 | 0.1666 |
84934 | RITA1 | P36T-E | Human | Esophagus | ESCC | 3.56e-15 | 3.84e-01 | 0.1187 |
84934 | RITA1 | P37T-E | Human | Esophagus | ESCC | 2.47e-11 | 2.21e-01 | 0.1371 |
84934 | RITA1 | P38T-E | Human | Esophagus | ESCC | 1.93e-04 | 2.04e-01 | 0.127 |
84934 | RITA1 | P39T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.05e-01 | 0.0894 |
84934 | RITA1 | P40T-E | Human | Esophagus | ESCC | 2.35e-12 | 3.41e-01 | 0.109 |
84934 | RITA1 | P42T-E | Human | Esophagus | ESCC | 3.60e-12 | 2.59e-01 | 0.1175 |
84934 | RITA1 | P47T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.08e-01 | 0.1067 |
84934 | RITA1 | P48T-E | Human | Esophagus | ESCC | 1.88e-11 | 1.76e-01 | 0.0959 |
84934 | RITA1 | P49T-E | Human | Esophagus | ESCC | 1.17e-11 | 6.67e-01 | 0.1768 |
84934 | RITA1 | P52T-E | Human | Esophagus | ESCC | 1.35e-23 | 4.24e-01 | 0.1555 |
84934 | RITA1 | P54T-E | Human | Esophagus | ESCC | 1.34e-09 | 2.43e-01 | 0.0975 |
84934 | RITA1 | P56T-E | Human | Esophagus | ESCC | 2.17e-07 | 5.36e-01 | 0.1613 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051168110 | Esophagus | ESCC | nuclear export | 126/8552 | 154/18723 | 1.88e-20 | 2.65e-18 | 126 |
GO:00072197 | Esophagus | ESCC | Notch signaling pathway | 106/8552 | 172/18723 | 1.74e-05 | 1.55e-04 | 106 |
GO:0045746 | Esophagus | ESCC | negative regulation of Notch signaling pathway | 28/8552 | 36/18723 | 8.62e-05 | 6.22e-04 | 28 |
GO:00085935 | Esophagus | ESCC | regulation of Notch signaling pathway | 59/8552 | 95/18723 | 9.12e-04 | 4.65e-03 | 59 |
GO:000691312 | Liver | Cirrhotic | nucleocytoplasmic transport | 118/4634 | 301/18723 | 1.71e-08 | 6.27e-07 | 118 |
GO:005116912 | Liver | Cirrhotic | nuclear transport | 118/4634 | 301/18723 | 1.71e-08 | 6.27e-07 | 118 |
GO:005116812 | Liver | Cirrhotic | nuclear export | 67/4634 | 154/18723 | 2.57e-07 | 6.41e-06 | 67 |
GO:000691322 | Liver | HCC | nucleocytoplasmic transport | 208/7958 | 301/18723 | 5.51e-21 | 8.12e-19 | 208 |
GO:005116922 | Liver | HCC | nuclear transport | 208/7958 | 301/18723 | 5.51e-21 | 8.12e-19 | 208 |
GO:005116822 | Liver | HCC | nuclear export | 113/7958 | 154/18723 | 6.30e-15 | 4.39e-13 | 113 |
GO:000691317 | Oral cavity | OSCC | nucleocytoplasmic transport | 204/7305 | 301/18723 | 2.65e-24 | 6.98e-22 | 204 |
GO:005116917 | Oral cavity | OSCC | nuclear transport | 204/7305 | 301/18723 | 2.65e-24 | 6.98e-22 | 204 |
GO:005116817 | Oral cavity | OSCC | nuclear export | 112/7305 | 154/18723 | 1.70e-17 | 1.56e-15 | 112 |
GO:00072196 | Oral cavity | OSCC | Notch signaling pathway | 92/7305 | 172/18723 | 7.84e-05 | 6.08e-04 | 92 |
GO:00085934 | Oral cavity | OSCC | regulation of Notch signaling pathway | 53/7305 | 95/18723 | 6.64e-04 | 3.72e-03 | 53 |
GO:000691324 | Skin | cSCC | nucleocytoplasmic transport | 162/4864 | 301/18723 | 4.20e-25 | 1.10e-22 | 162 |
GO:005116924 | Skin | cSCC | nuclear transport | 162/4864 | 301/18723 | 4.20e-25 | 1.10e-22 | 162 |
GO:0051168111 | Skin | cSCC | nuclear export | 91/4864 | 154/18723 | 3.33e-18 | 4.18e-16 | 91 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RITA1 | SNV | Missense_Mutation | rs767217662 | c.268N>A | p.Val90Met | p.V90M | Q96K30 | protein_coding | tolerated(0.09) | benign(0.082) | TCGA-EK-A2RC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RITA1 | SNV | Missense_Mutation | rs368110690 | c.455G>A | p.Arg152Gln | p.R152Q | Q96K30 | protein_coding | tolerated(0.29) | benign(0.199) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RITA1 | SNV | Missense_Mutation | rs773378868 | c.805N>T | p.Arg269Cys | p.R269C | Q96K30 | protein_coding | tolerated(0.27) | benign(0.001) | TCGA-AG-3885-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
RITA1 | SNV | Missense_Mutation | c.876N>T | p.Trp292Cys | p.W292C | Q96K30 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RITA1 | SNV | Missense_Mutation | rs76765925 | c.667N>C | p.Ser223Pro | p.S223P | Q96K30 | protein_coding | deleterious(0) | probably_damaging(0.92) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RITA1 | deletion | Frame_Shift_Del | novel | c.469delG | p.Asp157MetfsTer62 | p.D157Mfs*62 | Q96K30 | protein_coding | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
RITA1 | SNV | Missense_Mutation | rs367637594 | c.209N>A | p.Arg70Gln | p.R70Q | Q96K30 | protein_coding | tolerated(0.17) | benign(0.03) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
RITA1 | SNV | Missense_Mutation | rs777149039 | c.658N>T | p.Arg220Trp | p.R220W | Q96K30 | protein_coding | deleterious(0.01) | possibly_damaging(0.796) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
RITA1 | SNV | Missense_Mutation | rs538504098 | c.806N>A | p.Arg269His | p.R269H | Q96K30 | protein_coding | tolerated(0.77) | benign(0) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
RITA1 | SNV | Missense_Mutation | novel | c.59N>T | p.Gly20Val | p.G20V | Q96K30 | protein_coding | tolerated_low_confidence(0.34) | benign(0.375) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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