![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: RHEX |
Gene summary for RHEX |
![]() |
Gene information | Species | Human | Gene symbol | RHEX | Gene ID | 440712 |
Gene name | regulator of hemoglobinization and erythroid cell expansion | |
Gene Alias | C1orf186 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0002262 | UniProtAcc | Q6ZWK4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
440712 | RHEX | EEC-subject5 | Human | Endometrium | EEC | 6.81e-97 | 1.76e+00 | -0.249 |
440712 | RHEX | GSM5276935 | Human | Endometrium | EEC | 8.23e-05 | 1.55e-01 | -0.123 |
440712 | RHEX | GSM5276937 | Human | Endometrium | EEC | 4.79e-03 | 1.46e-01 | -0.0897 |
440712 | RHEX | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.03e-04 | 2.72e-01 | -0.1869 |
440712 | RHEX | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 8.95e-03 | 2.25e-01 | -0.1883 |
440712 | RHEX | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.25e-56 | 1.16e+00 | -0.1934 |
440712 | RHEX | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.82e-05 | 2.53e-01 | -0.1917 |
440712 | RHEX | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 6.56e-03 | 2.32e-01 | -0.1916 |
440712 | RHEX | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 1.25e-56 | 9.64e-01 | -0.1269 |
440712 | RHEX | EOLP-1 | Human | Oral cavity | EOLP | 1.53e-19 | 7.12e-01 | -0.0202 |
440712 | RHEX | EOLP-2 | Human | Oral cavity | EOLP | 2.79e-14 | 5.48e-01 | -0.0203 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003009910 | Cervix | CC | myeloid cell differentiation | 83/2311 | 381/18723 | 1.31e-07 | 6.42e-06 | 83 |
GO:190370610 | Cervix | CC | regulation of hemopoiesis | 80/2311 | 367/18723 | 2.14e-07 | 9.55e-06 | 80 |
GO:000226210 | Cervix | CC | myeloid cell homeostasis | 43/2311 | 157/18723 | 2.66e-07 | 1.12e-05 | 43 |
GO:003410110 | Cervix | CC | erythrocyte homeostasis | 37/2311 | 129/18723 | 5.16e-07 | 1.93e-05 | 37 |
GO:003021810 | Cervix | CC | erythrocyte differentiation | 34/2311 | 120/18723 | 2.00e-06 | 6.18e-05 | 34 |
GO:004887210 | Cervix | CC | homeostasis of number of cells | 61/2311 | 272/18723 | 2.17e-06 | 6.55e-05 | 61 |
GO:004563710 | Cervix | CC | regulation of myeloid cell differentiation | 48/2311 | 210/18723 | 1.49e-05 | 2.93e-04 | 48 |
GO:00456468 | Cervix | CC | regulation of erythrocyte differentiation | 17/2311 | 47/18723 | 2.38e-05 | 4.16e-04 | 17 |
GO:00456397 | Cervix | CC | positive regulation of myeloid cell differentiation | 28/2311 | 103/18723 | 3.56e-05 | 5.70e-04 | 28 |
GO:00192213 | Cervix | CC | cytokine-mediated signaling pathway | 84/2311 | 472/18723 | 3.25e-04 | 3.44e-03 | 84 |
GO:00456483 | Cervix | CC | positive regulation of erythrocyte differentiation | 12/2311 | 33/18723 | 3.53e-04 | 3.68e-03 | 12 |
GO:003009915 | Cervix | HSIL_HPV | myeloid cell differentiation | 36/737 | 381/18723 | 1.19e-06 | 5.62e-05 | 36 |
GO:190370613 | Cervix | HSIL_HPV | regulation of hemopoiesis | 35/737 | 367/18723 | 1.35e-06 | 6.21e-05 | 35 |
GO:004563715 | Cervix | HSIL_HPV | regulation of myeloid cell differentiation | 22/737 | 210/18723 | 2.97e-05 | 8.57e-04 | 22 |
GO:000226215 | Cervix | HSIL_HPV | myeloid cell homeostasis | 18/737 | 157/18723 | 4.75e-05 | 1.21e-03 | 18 |
GO:003410115 | Cervix | HSIL_HPV | erythrocyte homeostasis | 16/737 | 129/18723 | 4.76e-05 | 1.21e-03 | 16 |
GO:004563913 | Cervix | HSIL_HPV | positive regulation of myeloid cell differentiation | 13/737 | 103/18723 | 2.00e-04 | 3.65e-03 | 13 |
GO:001922111 | Cervix | HSIL_HPV | cytokine-mediated signaling pathway | 35/737 | 472/18723 | 2.64e-04 | 4.52e-03 | 35 |
GO:003021815 | Cervix | HSIL_HPV | erythrocyte differentiation | 14/737 | 120/18723 | 2.67e-04 | 4.54e-03 | 14 |
GO:004564811 | Cervix | HSIL_HPV | positive regulation of erythrocyte differentiation | 6/737 | 33/18723 | 1.63e-03 | 1.77e-02 | 6 |
Page: 1 2 3 4 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |