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Gene: RHEB |
Gene summary for RHEB |
Gene summary. |
Gene information | Species | Human | Gene symbol | RHEB | Gene ID | 6009 |
Gene name | Ras homolog, mTORC1 binding | |
Gene Alias | RHEB2 | |
Cytomap | 7q36.1 | |
Gene Type | protein-coding | GO ID | GO:0001659 | UniProtAcc | A0A090N900 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6009 | RHEB | M1 | Human | Breast | IDC | 7.24e-05 | -3.71e-01 | 0.1577 |
6009 | RHEB | NCCBC14 | Human | Breast | DCIS | 1.00e-20 | -1.32e-01 | 0.2021 |
6009 | RHEB | NCCBC2 | Human | Breast | DCIS | 7.55e-06 | -4.80e-01 | 0.1554 |
6009 | RHEB | NCCBC3 | Human | Breast | DCIS | 7.62e-08 | -3.38e-01 | 0.1198 |
6009 | RHEB | NCCBC5 | Human | Breast | DCIS | 5.76e-17 | -2.85e-01 | 0.2046 |
6009 | RHEB | P1 | Human | Breast | IDC | 1.02e-28 | -6.00e-01 | 0.1527 |
6009 | RHEB | DCIS2 | Human | Breast | DCIS | 8.93e-60 | -9.33e-02 | 0.0085 |
6009 | RHEB | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.35e-10 | 6.48e-01 | 0.281 |
6009 | RHEB | A015-C-203 | Human | Colorectum | FAP | 1.36e-10 | -1.80e-01 | -0.1294 |
6009 | RHEB | A002-C-201 | Human | Colorectum | FAP | 3.26e-02 | -1.58e-01 | 0.0324 |
6009 | RHEB | A001-C-108 | Human | Colorectum | FAP | 1.67e-07 | -1.26e-01 | -0.0272 |
6009 | RHEB | A002-C-205 | Human | Colorectum | FAP | 1.11e-04 | -2.02e-01 | -0.1236 |
6009 | RHEB | A015-C-006 | Human | Colorectum | FAP | 4.09e-02 | -1.71e-01 | -0.0994 |
6009 | RHEB | A015-C-106 | Human | Colorectum | FAP | 7.56e-06 | -8.33e-02 | -0.0511 |
6009 | RHEB | A002-C-114 | Human | Colorectum | FAP | 4.09e-04 | -2.06e-01 | -0.1561 |
6009 | RHEB | A015-C-104 | Human | Colorectum | FAP | 3.51e-10 | -2.28e-01 | -0.1899 |
6009 | RHEB | A001-C-014 | Human | Colorectum | FAP | 6.25e-04 | -1.57e-01 | 0.0135 |
6009 | RHEB | A002-C-016 | Human | Colorectum | FAP | 1.86e-07 | -1.70e-01 | 0.0521 |
6009 | RHEB | A001-C-203 | Human | Colorectum | FAP | 6.99e-05 | -8.82e-02 | -0.0481 |
6009 | RHEB | A002-C-116 | Human | Colorectum | FAP | 1.13e-10 | -1.70e-01 | -0.0452 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00420633 | Breast | Precancer | gliogenesis | 33/1080 | 301/18723 | 3.06e-04 | 4.40e-03 | 33 |
GO:00100013 | Breast | Precancer | glial cell differentiation | 25/1080 | 225/18723 | 1.29e-03 | 1.37e-02 | 25 |
GO:00020649 | Breast | Precancer | epithelial cell development | 23/1080 | 220/18723 | 4.28e-03 | 3.35e-02 | 23 |
GO:004206311 | Breast | IDC | gliogenesis | 39/1434 | 301/18723 | 8.63e-04 | 1.00e-02 | 39 |
GO:00100011 | Breast | IDC | glial cell differentiation | 31/1434 | 225/18723 | 1.04e-03 | 1.15e-02 | 31 |
GO:000206414 | Breast | IDC | epithelial cell development | 28/1434 | 220/18723 | 5.53e-03 | 4.05e-02 | 28 |
GO:00420632 | Breast | DCIS | gliogenesis | 39/1390 | 301/18723 | 4.76e-04 | 6.25e-03 | 39 |
GO:00100012 | Breast | DCIS | glial cell differentiation | 31/1390 | 225/18723 | 6.24e-04 | 7.87e-03 | 31 |
GO:00020642 | Colorectum | MSS | epithelial cell development | 81/3467 | 220/18723 | 1.02e-10 | 1.06e-08 | 81 |
GO:00162362 | Colorectum | MSS | macroautophagy | 93/3467 | 291/18723 | 2.08e-08 | 1.17e-06 | 93 |
GO:00105062 | Colorectum | MSS | regulation of autophagy | 95/3467 | 317/18723 | 4.36e-07 | 1.71e-05 | 95 |
GO:00107202 | Colorectum | MSS | positive regulation of cell development | 81/3467 | 298/18723 | 1.38e-04 | 2.06e-03 | 81 |
GO:00162412 | Colorectum | MSS | regulation of macroautophagy | 44/3467 | 141/18723 | 1.88e-04 | 2.64e-03 | 44 |
GO:00507671 | Colorectum | MSS | regulation of neurogenesis | 94/3467 | 364/18723 | 3.12e-04 | 4.06e-03 | 94 |
GO:0050769 | Colorectum | MSS | positive regulation of neurogenesis | 57/3467 | 225/18723 | 6.60e-03 | 4.38e-02 | 57 |
GO:0051960 | Colorectum | MSS | regulation of nervous system development | 103/3467 | 443/18723 | 6.68e-03 | 4.38e-02 | 103 |
GO:0031929 | Colorectum | MSS | TOR signaling | 35/3467 | 126/18723 | 6.91e-03 | 4.44e-02 | 35 |
GO:00020644 | Colorectum | FAP | epithelial cell development | 62/2622 | 220/18723 | 2.74e-08 | 2.54e-06 | 62 |
GO:00105063 | Colorectum | FAP | regulation of autophagy | 80/2622 | 317/18723 | 6.43e-08 | 4.54e-06 | 80 |
GO:00107203 | Colorectum | FAP | positive regulation of cell development | 72/2622 | 298/18723 | 1.67e-06 | 6.99e-05 | 72 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa042189 | Breast | Precancer | Cellular senescence | 29/684 | 156/8465 | 1.66e-05 | 1.69e-04 | 1.30e-04 | 29 |
hsa0516316 | Breast | Precancer | Human cytomegalovirus infection | 32/684 | 225/8465 | 1.13e-03 | 7.57e-03 | 5.80e-03 | 32 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0421814 | Breast | Precancer | Cellular senescence | 29/684 | 156/8465 | 1.66e-05 | 1.69e-04 | 1.30e-04 | 29 |
hsa0516317 | Breast | Precancer | Human cytomegalovirus infection | 32/684 | 225/8465 | 1.13e-03 | 7.57e-03 | 5.80e-03 | 32 |
hsa0471424 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0421824 | Breast | IDC | Cellular senescence | 35/867 | 156/8465 | 5.49e-06 | 7.43e-05 | 5.56e-05 | 35 |
hsa0516324 | Breast | IDC | Human cytomegalovirus infection | 39/867 | 225/8465 | 6.66e-04 | 5.41e-03 | 4.05e-03 | 39 |
hsa0491916 | Breast | IDC | Thyroid hormone signaling pathway | 23/867 | 121/8465 | 2.45e-03 | 1.69e-02 | 1.27e-02 | 23 |
hsa0471434 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0421834 | Breast | IDC | Cellular senescence | 35/867 | 156/8465 | 5.49e-06 | 7.43e-05 | 5.56e-05 | 35 |
hsa0516334 | Breast | IDC | Human cytomegalovirus infection | 39/867 | 225/8465 | 6.66e-04 | 5.41e-03 | 4.05e-03 | 39 |
hsa0491917 | Breast | IDC | Thyroid hormone signaling pathway | 23/867 | 121/8465 | 2.45e-03 | 1.69e-02 | 1.27e-02 | 23 |
hsa0471443 | Breast | DCIS | Thermogenesis | 74/846 | 232/8465 | 8.72e-21 | 3.13e-19 | 2.30e-19 | 74 |
hsa0421844 | Breast | DCIS | Cellular senescence | 34/846 | 156/8465 | 8.53e-06 | 1.06e-04 | 7.80e-05 | 34 |
hsa0516344 | Breast | DCIS | Human cytomegalovirus infection | 38/846 | 225/8465 | 8.11e-04 | 5.95e-03 | 4.38e-03 | 38 |
hsa0491922 | Breast | DCIS | Thyroid hormone signaling pathway | 23/846 | 121/8465 | 1.78e-03 | 1.22e-02 | 9.00e-03 | 23 |
hsa0471453 | Breast | DCIS | Thermogenesis | 74/846 | 232/8465 | 8.72e-21 | 3.13e-19 | 2.30e-19 | 74 |
hsa0421854 | Breast | DCIS | Cellular senescence | 34/846 | 156/8465 | 8.53e-06 | 1.06e-04 | 7.80e-05 | 34 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RHEB | SNV | Missense_Mutation | c.85N>A | p.Gly29Ser | p.G29S | Q15382 | protein_coding | tolerated(0.07) | probably_damaging(0.967) | TCGA-A8-A06U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RHEB | insertion | Nonsense_Mutation | novel | c.100_101insACAAAGCCTAAAATATTTACTGGTACTGTCTGGC | p.Ser34TyrfsTer4 | p.S34Yfs*4 | Q15382 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
RHEB | SNV | Missense_Mutation | c.125N>T | p.Thr42Ile | p.T42I | Q15382 | protein_coding | deleterious(0.03) | probably_damaging(0.995) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RHEB | SNV | Missense_Mutation | rs867628277 | c.68N>T | p.Thr23Met | p.T23M | Q15382 | protein_coding | deleterious(0) | benign(0.288) | TCGA-CK-4952-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RHEB | SNV | Missense_Mutation | c.383T>A | p.Val128Glu | p.V128E | Q15382 | protein_coding | tolerated(0.58) | benign(0.026) | TCGA-G5-6641-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
RHEB | SNV | Missense_Mutation | c.125C>A | p.Thr42Asn | p.T42N | Q15382 | protein_coding | deleterious(0.02) | probably_damaging(0.99) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RHEB | SNV | Missense_Mutation | c.103N>A | p.Tyr35Asn | p.Y35N | Q15382 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A11W-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RHEB | SNV | Missense_Mutation | novel | c.449C>T | p.Ala150Val | p.A150V | Q15382 | protein_coding | tolerated(0.05) | probably_damaging(1) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RHEB | SNV | Missense_Mutation | c.70N>G | p.Ile24Val | p.I24V | Q15382 | protein_coding | tolerated(0.99) | possibly_damaging(0.65) | TCGA-BS-A0V6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RHEB | SNV | Missense_Mutation | novel | c.78N>G | p.Phe26Leu | p.F26L | Q15382 | protein_coding | deleterious(0.02) | possibly_damaging(0.693) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6009 | RHEB | TUMOR SUPPRESSOR, DRUG RESISTANCE, KINASE, CLINICALLY ACTIONABLE | 4,4'-HYDROXYBIPHENYL | CHEMBL76398 | 24266771 | |
6009 | RHEB | TUMOR SUPPRESSOR, DRUG RESISTANCE, KINASE, CLINICALLY ACTIONABLE | SIROLIMUS | SIROLIMUS | 26255626 |
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