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Gene: REX1BD |
Gene summary for REX1BD |
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Gene information | Species | Human | Gene symbol | REX1BD | Gene ID | 55049 |
Gene name | required for excision 1-B domain containing | |
Gene Alias | C19orf60 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q96EN9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55049 | REX1BD | GSM4909309 | Human | Breast | IDC | 5.49e-05 | 3.15e-01 | 0.0483 |
55049 | REX1BD | GSM4909311 | Human | Breast | IDC | 1.34e-05 | -7.54e-03 | 0.1534 |
55049 | REX1BD | GSM4909313 | Human | Breast | IDC | 1.89e-02 | 2.16e-01 | 0.0391 |
55049 | REX1BD | GSM4909315 | Human | Breast | IDC | 8.33e-13 | 4.60e-01 | 0.21 |
55049 | REX1BD | GSM4909317 | Human | Breast | IDC | 6.32e-10 | 3.51e-01 | 0.1355 |
55049 | REX1BD | GSM4909319 | Human | Breast | IDC | 3.19e-10 | 5.93e-02 | 0.1563 |
55049 | REX1BD | GSM4909320 | Human | Breast | IDC | 1.11e-34 | 1.11e+00 | 0.1575 |
55049 | REX1BD | GSM4909321 | Human | Breast | IDC | 9.41e-59 | 1.09e+00 | 0.1559 |
55049 | REX1BD | brca1 | Human | Breast | Precancer | 3.85e-08 | -2.71e-01 | -0.0338 |
55049 | REX1BD | brca2 | Human | Breast | Precancer | 1.72e-05 | -2.71e-01 | -0.024 |
55049 | REX1BD | brca3 | Human | Breast | Precancer | 8.07e-06 | -2.71e-01 | -0.0263 |
55049 | REX1BD | M1 | Human | Breast | IDC | 6.73e-17 | 5.42e-01 | 0.1577 |
55049 | REX1BD | NCCBC5 | Human | Breast | DCIS | 3.40e-24 | 6.63e-01 | 0.2046 |
55049 | REX1BD | P1 | Human | Breast | IDC | 1.21e-04 | 1.14e-01 | 0.1527 |
55049 | REX1BD | DCIS2 | Human | Breast | DCIS | 9.92e-69 | 2.84e-01 | 0.0085 |
55049 | REX1BD | CA_HPV_1 | Human | Cervix | CC | 2.25e-07 | -7.80e-02 | 0.0264 |
55049 | REX1BD | CCI_1 | Human | Cervix | CC | 4.30e-07 | -5.62e-01 | 0.528 |
55049 | REX1BD | CCI_2 | Human | Cervix | CC | 3.90e-05 | -5.39e-01 | 0.5249 |
55049 | REX1BD | CCI_3 | Human | Cervix | CC | 2.74e-10 | -5.67e-01 | 0.516 |
55049 | REX1BD | CCII_1 | Human | Cervix | CC | 3.18e-05 | -4.31e-01 | 0.3249 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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