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Gene: RCN2 |
Gene summary for RCN2 |
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Gene information | Species | Human | Gene symbol | RCN2 | Gene ID | 5955 |
Gene name | reticulocalbin 2 | |
Gene Alias | E6BP | |
Cytomap | 15q24.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q14257 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5955 | RCN2 | LZE2T | Human | Esophagus | ESCC | 2.46e-10 | 1.87e+00 | 0.082 |
5955 | RCN2 | LZE4T | Human | Esophagus | ESCC | 1.96e-16 | 7.35e-01 | 0.0811 |
5955 | RCN2 | LZE5T | Human | Esophagus | ESCC | 2.01e-03 | 4.72e-01 | 0.0514 |
5955 | RCN2 | LZE7T | Human | Esophagus | ESCC | 6.21e-07 | 7.35e-01 | 0.0667 |
5955 | RCN2 | LZE8T | Human | Esophagus | ESCC | 1.16e-04 | -1.09e-01 | 0.067 |
5955 | RCN2 | LZE20T | Human | Esophagus | ESCC | 6.28e-07 | 3.12e-01 | 0.0662 |
5955 | RCN2 | LZE22D1 | Human | Esophagus | HGIN | 1.21e-03 | 1.77e-01 | 0.0595 |
5955 | RCN2 | LZE22T | Human | Esophagus | ESCC | 2.46e-04 | 1.10e+00 | 0.068 |
5955 | RCN2 | LZE24T | Human | Esophagus | ESCC | 1.36e-20 | 9.34e-01 | 0.0596 |
5955 | RCN2 | LZE21T | Human | Esophagus | ESCC | 6.99e-06 | 8.80e-01 | 0.0655 |
5955 | RCN2 | P1T-E | Human | Esophagus | ESCC | 3.68e-12 | 1.33e+00 | 0.0875 |
5955 | RCN2 | P2T-E | Human | Esophagus | ESCC | 4.92e-108 | 1.94e+00 | 0.1177 |
5955 | RCN2 | P4T-E | Human | Esophagus | ESCC | 9.66e-88 | 2.56e+00 | 0.1323 |
5955 | RCN2 | P5T-E | Human | Esophagus | ESCC | 4.66e-17 | 4.77e-01 | 0.1327 |
5955 | RCN2 | P8T-E | Human | Esophagus | ESCC | 1.85e-84 | 1.86e+00 | 0.0889 |
5955 | RCN2 | P9T-E | Human | Esophagus | ESCC | 2.82e-44 | 1.38e+00 | 0.1131 |
5955 | RCN2 | P10T-E | Human | Esophagus | ESCC | 3.82e-109 | 2.55e+00 | 0.116 |
5955 | RCN2 | P11T-E | Human | Esophagus | ESCC | 4.70e-34 | 1.73e+00 | 0.1426 |
5955 | RCN2 | P12T-E | Human | Esophagus | ESCC | 8.79e-106 | 2.41e+00 | 0.1122 |
5955 | RCN2 | P15T-E | Human | Esophagus | ESCC | 1.23e-63 | 1.89e+00 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RCN2 | SNV | Missense_Mutation | novel | c.563N>A | p.Ser188Asn | p.S188N | Q14257 | protein_coding | tolerated(1) | benign(0.001) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RCN2 | SNV | Missense_Mutation | c.919C>A | p.Leu307Met | p.L307M | Q14257 | protein_coding | tolerated(0.06) | benign(0.232) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
RCN2 | SNV | Missense_Mutation | rs766204743 | c.784N>A | p.Asp262Asn | p.D262N | Q14257 | protein_coding | tolerated(0.12) | benign(0.062) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RCN2 | deletion | Frame_Shift_Del | c.331delN | p.Asn112ThrfsTer6 | p.N112Tfs*6 | Q14257 | protein_coding | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
RCN2 | SNV | Missense_Mutation | novel | c.443N>T | p.Arg148Met | p.R148M | Q14257 | protein_coding | deleterious(0.01) | probably_damaging(0.974) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RCN2 | SNV | Missense_Mutation | rs556906206 | c.494G>A | p.Arg165Gln | p.R165Q | Q14257 | protein_coding | tolerated(0.1) | benign(0.009) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
RCN2 | SNV | Missense_Mutation | novel | c.473N>T | p.Ser158Phe | p.S158F | Q14257 | protein_coding | tolerated_low_confidence(0.35) | benign(0.003) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RCN2 | SNV | Missense_Mutation | rs751566644 | c.844N>A | p.Ala282Thr | p.A282T | Q14257 | protein_coding | deleterious(0) | possibly_damaging(0.82) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RCN2 | SNV | Missense_Mutation | rs770494865 | c.936N>T | p.Leu312Phe | p.L312F | Q14257 | protein_coding | deleterious(0) | possibly_damaging(0.694) | TCGA-BG-A187-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RCN2 | SNV | Missense_Mutation | novel | c.602N>C | p.Val201Ala | p.V201A | Q14257 | protein_coding | tolerated(0.14) | possibly_damaging(0.57) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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