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Gene: RBL2 |
Gene summary for RBL2 |
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Gene information | Species | Human | Gene symbol | RBL2 | Gene ID | 5934 |
Gene name | RB transcriptional corepressor like 2 | |
Gene Alias | P130 | |
Cytomap | 16q12.2 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | Q08999 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5934 | RBL2 | P21T-E | Human | Esophagus | ESCC | 1.51e-22 | 5.12e-01 | 0.1617 |
5934 | RBL2 | P22T-E | Human | Esophagus | ESCC | 8.47e-18 | 3.25e-01 | 0.1236 |
5934 | RBL2 | P23T-E | Human | Esophagus | ESCC | 2.90e-10 | 3.59e-01 | 0.108 |
5934 | RBL2 | P24T-E | Human | Esophagus | ESCC | 7.07e-13 | 2.47e-01 | 0.1287 |
5934 | RBL2 | P26T-E | Human | Esophagus | ESCC | 9.27e-31 | 5.75e-01 | 0.1276 |
5934 | RBL2 | P27T-E | Human | Esophagus | ESCC | 4.66e-13 | 3.43e-01 | 0.1055 |
5934 | RBL2 | P28T-E | Human | Esophagus | ESCC | 4.59e-13 | 2.51e-01 | 0.1149 |
5934 | RBL2 | P30T-E | Human | Esophagus | ESCC | 5.78e-26 | 1.08e+00 | 0.137 |
5934 | RBL2 | P31T-E | Human | Esophagus | ESCC | 8.92e-26 | 4.25e-01 | 0.1251 |
5934 | RBL2 | P32T-E | Human | Esophagus | ESCC | 4.52e-19 | 2.95e-01 | 0.1666 |
5934 | RBL2 | P36T-E | Human | Esophagus | ESCC | 1.33e-07 | 3.63e-01 | 0.1187 |
5934 | RBL2 | P37T-E | Human | Esophagus | ESCC | 1.69e-19 | 2.85e-01 | 0.1371 |
5934 | RBL2 | P38T-E | Human | Esophagus | ESCC | 4.69e-03 | 6.19e-02 | 0.127 |
5934 | RBL2 | P39T-E | Human | Esophagus | ESCC | 2.78e-13 | 2.34e-01 | 0.0894 |
5934 | RBL2 | P40T-E | Human | Esophagus | ESCC | 4.82e-06 | 1.17e-01 | 0.109 |
5934 | RBL2 | P42T-E | Human | Esophagus | ESCC | 2.41e-18 | 5.24e-01 | 0.1175 |
5934 | RBL2 | P44T-E | Human | Esophagus | ESCC | 2.09e-08 | 3.50e-01 | 0.1096 |
5934 | RBL2 | P47T-E | Human | Esophagus | ESCC | 9.58e-12 | 2.37e-01 | 0.1067 |
5934 | RBL2 | P48T-E | Human | Esophagus | ESCC | 5.95e-14 | 3.12e-01 | 0.0959 |
5934 | RBL2 | P49T-E | Human | Esophagus | ESCC | 2.57e-11 | 9.22e-01 | 0.1768 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000632516 | Esophagus | HGIN | chromatin organization | 92/2587 | 409/18723 | 1.05e-06 | 4.16e-05 | 92 |
GO:000734610 | Esophagus | HGIN | regulation of mitotic cell cycle | 98/2587 | 457/18723 | 4.39e-06 | 1.42e-04 | 98 |
GO:00447729 | Esophagus | HGIN | mitotic cell cycle phase transition | 89/2587 | 424/18723 | 2.80e-05 | 7.21e-04 | 89 |
GO:19019906 | Esophagus | HGIN | regulation of mitotic cell cycle phase transition | 65/2587 | 299/18723 | 1.12e-04 | 2.36e-03 | 65 |
GO:20000456 | Esophagus | HGIN | regulation of G1/S transition of mitotic cell cycle | 36/2587 | 142/18723 | 1.74e-04 | 3.35e-03 | 36 |
GO:00000827 | Esophagus | HGIN | G1/S transition of mitotic cell cycle | 48/2587 | 214/18723 | 3.97e-04 | 6.07e-03 | 48 |
GO:00448437 | Esophagus | HGIN | cell cycle G1/S phase transition | 52/2587 | 241/18723 | 6.19e-04 | 8.58e-03 | 52 |
GO:19028065 | Esophagus | HGIN | regulation of cell cycle G1/S phase transition | 39/2587 | 168/18723 | 6.60e-04 | 9.03e-03 | 39 |
GO:20001343 | Esophagus | HGIN | negative regulation of G1/S transition of mitotic cell cycle | 23/2587 | 84/18723 | 7.90e-04 | 1.03e-02 | 23 |
GO:00459305 | Esophagus | HGIN | negative regulation of mitotic cell cycle | 49/2587 | 235/18723 | 1.88e-03 | 2.01e-02 | 49 |
GO:19019915 | Esophagus | HGIN | negative regulation of mitotic cell cycle phase transition | 39/2587 | 179/18723 | 2.31e-03 | 2.36e-02 | 39 |
GO:19028073 | Esophagus | HGIN | negative regulation of cell cycle G1/S phase transition | 23/2587 | 93/18723 | 3.39e-03 | 3.18e-02 | 23 |
GO:19019876 | Esophagus | HGIN | regulation of cell cycle phase transition | 72/2587 | 390/18723 | 5.78e-03 | 4.70e-02 | 72 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:190199013 | Esophagus | ESCC | regulation of mitotic cell cycle phase transition | 191/8552 | 299/18723 | 1.35e-10 | 3.94e-09 | 191 |
GO:00457865 | Esophagus | ESCC | negative regulation of cell cycle | 236/8552 | 385/18723 | 3.62e-10 | 9.93e-09 | 236 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00109484 | Esophagus | ESCC | negative regulation of cell cycle process | 177/8552 | 294/18723 | 3.26e-07 | 4.59e-06 | 177 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052039 | Esophagus | HGIN | Viral carcinogenesis | 53/1383 | 204/8465 | 2.58e-04 | 2.71e-03 | 2.15e-03 | 53 |
hsa0421828 | Esophagus | HGIN | Cellular senescence | 42/1383 | 156/8465 | 4.94e-04 | 5.03e-03 | 4.00e-03 | 42 |
hsa041109 | Esophagus | HGIN | Cell cycle | 38/1383 | 157/8465 | 6.70e-03 | 4.37e-02 | 3.47e-02 | 38 |
hsa0520315 | Esophagus | HGIN | Viral carcinogenesis | 53/1383 | 204/8465 | 2.58e-04 | 2.71e-03 | 2.15e-03 | 53 |
hsa04218111 | Esophagus | HGIN | Cellular senescence | 42/1383 | 156/8465 | 4.94e-04 | 5.03e-03 | 4.00e-03 | 42 |
hsa0411016 | Esophagus | HGIN | Cell cycle | 38/1383 | 157/8465 | 6.70e-03 | 4.37e-02 | 3.47e-02 | 38 |
hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa0421829 | Esophagus | ESCC | Cellular senescence | 119/4205 | 156/8465 | 5.89e-12 | 9.40e-11 | 4.81e-11 | 119 |
hsa0516510 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0520325 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa040689 | Esophagus | ESCC | FoxO signaling pathway | 89/4205 | 131/8465 | 1.56e-05 | 7.98e-05 | 4.09e-05 | 89 |
hsa041517 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa0421838 | Esophagus | ESCC | Cellular senescence | 119/4205 | 156/8465 | 5.89e-12 | 9.40e-11 | 4.81e-11 | 119 |
hsa0516515 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0520335 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa0406814 | Esophagus | ESCC | FoxO signaling pathway | 89/4205 | 131/8465 | 1.56e-05 | 7.98e-05 | 4.09e-05 | 89 |
hsa0415114 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa04068 | Liver | NAFLD | FoxO signaling pathway | 30/1043 | 131/8465 | 4.91e-04 | 8.05e-03 | 6.49e-03 | 30 |
hsa040681 | Liver | NAFLD | FoxO signaling pathway | 30/1043 | 131/8465 | 4.91e-04 | 8.05e-03 | 6.49e-03 | 30 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RBL2 | SNV | Missense_Mutation | novel | c.873G>T | p.Lys291Asn | p.K291N | Q08999 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
RBL2 | SNV | Missense_Mutation | rs376376448 | c.547N>T | p.Arg183Cys | p.R183C | Q08999 | protein_coding | deleterious(0.01) | benign(0.039) | TCGA-AN-A041-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RBL2 | SNV | Missense_Mutation | novel | c.1504N>T | p.Val502Leu | p.V502L | Q08999 | protein_coding | tolerated(0.3) | benign(0.131) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RBL2 | SNV | Missense_Mutation | novel | c.1594N>G | p.Leu532Val | p.L532V | Q08999 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
RBL2 | SNV | Missense_Mutation | c.2071N>A | p.Asp691Asn | p.D691N | Q08999 | protein_coding | tolerated(0.12) | benign(0.051) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
RBL2 | SNV | Missense_Mutation | novel | c.3305G>C | p.Arg1102Thr | p.R1102T | Q08999 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
RBL2 | SNV | Missense_Mutation | novel | c.430N>G | p.His144Asp | p.H144D | Q08999 | protein_coding | tolerated(0.51) | benign(0) | TCGA-VS-A9UC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
RBL2 | SNV | Missense_Mutation | rs371003080 | c.1111G>A | p.Ala371Thr | p.A371T | Q08999 | protein_coding | tolerated(0.6) | benign(0) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RBL2 | SNV | Missense_Mutation | c.1957N>G | p.Thr653Ala | p.T653A | Q08999 | protein_coding | tolerated(0.77) | benign(0) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
RBL2 | SNV | Missense_Mutation | c.3276N>G | p.Ile1092Met | p.I1092M | Q08999 | protein_coding | tolerated(0.13) | possibly_damaging(0.708) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5934 | RBL2 | TRANSCRIPTION FACTOR COMPLEX, ENZYME | RAPAMYCIN | SIROLIMUS | 8895523 |
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